set of weak interactions leading to a significant stabilization of the transition state
responsible for the major product formation. However, the iridium-catalyzed alkane
CÀH borylation suffered from poor atom economy, resulting from both the inclusion of only one equiv. of boron from the diboron reagent and a requirement for neat
substrate.
A rate acceleration on the iridium-catalyzed alkane CÀH borylation, particularly
on C(sp
3 )–H bonds located on the methyl groups of isopropyl groups, has been
promoted by the addition of a catalytic amount of t-BuOK (Scheme 16)
[36]. Although no mechanistic explanation was given for this observation, authors
Scheme 14 Suggested iridium-catalyzed CÀH borylation of methylarenes
Scheme 15 Iridium-catalyzed regioselective CÀH borylation of primary C–H bonds beta to
nitrogen and oxygen
218
E. Fernández
responsible for the major product formation. However, the iridium-catalyzed alkane
CÀH borylation suffered from poor atom economy, resulting from both the inclusion of only one equiv. of boron from the diboron reagent and a requirement for neat
substrate.
A rate acceleration on the iridium-catalyzed alkane CÀH borylation, particularly
on C(sp
3 )–H bonds located on the methyl groups of isopropyl groups, has been
promoted by the addition of a catalytic amount of t-BuOK (Scheme 16)
[36]. Although no mechanistic explanation was given for this observation, authors
Scheme 14 Suggested iridium-catalyzed CÀH borylation of methylarenes
Scheme 15 Iridium-catalyzed regioselective CÀH borylation of primary C–H bonds beta to
nitrogen and oxygen
218
E. Fernández