Huo M, Gao R, Jiang L, Cui X, Duan L, Deng X, Guan S, Wei J, Soromou LW, Feng H, Chi G
(2013) Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells
and mouse models. Int Immunopharmacol 15(2):442–449
Kakani R, Gamboa DA, Calhoun MC, Haq AU, Bailey CA (2010) Relative toxicity of cottonseed
gossypol enantiomers in broilers. Open Toxicol J 4:26–31
Kenar JA (2006) Reaction chemistry of gossypol and its derivatives. J Am Oil Chem Soc 83
(4):269–302
Ko CH, Shen SC, Yang LY, Lin CW, Chen YC (2007) Gossypol reduction of tumor growth
through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. Int J
Cancer 121(8):1670–1679
Li H, Piao L, Xu P, Ye W, Zhong S, Lin SH, Kulp SK, Mao Y, Cho Y, Lee LJ, Lee RJ (2011)
Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells. Pharm Res 28(12):3256–3264
Lin YC, Chitcharoenthum M, Rikihisa Y (1990) Effect of gossypol on thyroid hormones in young
female rats. Contraception 41(4):431–440
Lindsey TO, Hawkins GE, Guthrie LD (1980) Physiological responses of lactating cows to
gossypol from cottonseed meal rations. J Dairy Sci 63(4):562–573
Liu S, Kulp SK, Sugimoto Y, Jiang J, Chang HL, Dowd MK, Wan P, Lin YC (2002) The (-)enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human
breast cancer. Anticancer Res 22(1A):33–38
Madar Z, Nir M, Trostler N, Norenberg C (1988) Effects of cottonseed dietary fiber on metabolic
parameters in diabetic rats and non-insulin-dependent diabetic humans. J Nutr 118
(9):1143–1148
Mahmood F, Khan MZ, Khan A, Muhammad G, Javed I (2011) Lysine induced modulation of
toxico-pathological effects of cottonseed meal in broiler breeder males. Pak J Zool 43
(2):357–365
Manabe S, Nuber DC, Lin YC (1991) Zone-specific hepatotoxicity of gossypol in perfused rat liver.
Toxicon 29(6):787–790
Mellon JE, Zelaya CA, Dowd MK, Beltz SB, Klich MA (2012) Inhibitory effects of gossypol,
gossypolone, and apogossypolone on a collection of economically important filamentous fungi.
J Agric Food Chem 60(10):2740–2745
Mena H, Santos JEP, Huber JT, Tarazon M, Calhoun MC (2004) The effects of varying gossypol
intake from whole cottonseed and cottonseed meal on lactation and blood parameters in
lactating dairy cows. J Dairy Sci 87(8):2506–2518
Morgan S, Stair EL, Martin T, Edwards WC, Morgan GL (1988) Clinical, clinicopathologic,
pathologic, and toxicologic alterations associated with gossypol toxicosis in feeder lambs. Am
J Vet Res 49(4):493–499
Nagalakshmi D, Rao SVR, Panda AK, Sastry VR (2007) Cottonseed meal in poultry diets: a review.
J Poult Sci 44(2):119–134
Namuli A, Abdullah N, Sieo CC, Zuhainis SW, Oskoueian E (2011) Phytochemical compounds
and antibacterial activity of Jatropha curcas Linn. extracts. J Med Plant Res 5(16):3982–3990
O’Brien RD, Jones, LA, King CC, Wakelyn PJ, Wan PJ (2005) Cottonseed oil, In: Shahidi F
(ed) Bailey’s industrial oil and fat products, vol. 2, 6th edn. John Wiley & Sons, Inc., Hoboken,
NJ, pp. 173–279
Ory RL, Flick GJ (1994) Peanut and cottonseed proteins for food uses. In: Hudson BJF (ed) New
and developing sources of food proteins. Springer, Boston, MA, pp 195–240
Oskoueian E, Abdullah N, Hendra R, Karimi E (2011a) Bioactive compounds, antioxidant,
xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected
agro-industrial by-products. Int J Mol Sci 12(12):8610–8625
Oskoueian E, Abdullah N, Ahmad S, Saad WZ, Omar AR, Ho YW (2011b) Bioactive compounds
and biological activities of Jatropha curcas L. kernel meal extract. Int J Mol Sci 12
(9):5955–5970
90
M. K. Sihag et al.
(2013) Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells
and mouse models. Int Immunopharmacol 15(2):442–449
Kakani R, Gamboa DA, Calhoun MC, Haq AU, Bailey CA (2010) Relative toxicity of cottonseed
gossypol enantiomers in broilers. Open Toxicol J 4:26–31
Kenar JA (2006) Reaction chemistry of gossypol and its derivatives. J Am Oil Chem Soc 83
(4):269–302
Ko CH, Shen SC, Yang LY, Lin CW, Chen YC (2007) Gossypol reduction of tumor growth
through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. Int J
Cancer 121(8):1670–1679
Li H, Piao L, Xu P, Ye W, Zhong S, Lin SH, Kulp SK, Mao Y, Cho Y, Lee LJ, Lee RJ (2011)
Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells. Pharm Res 28(12):3256–3264
Lin YC, Chitcharoenthum M, Rikihisa Y (1990) Effect of gossypol on thyroid hormones in young
female rats. Contraception 41(4):431–440
Lindsey TO, Hawkins GE, Guthrie LD (1980) Physiological responses of lactating cows to
gossypol from cottonseed meal rations. J Dairy Sci 63(4):562–573
Liu S, Kulp SK, Sugimoto Y, Jiang J, Chang HL, Dowd MK, Wan P, Lin YC (2002) The (-)enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human
breast cancer. Anticancer Res 22(1A):33–38
Madar Z, Nir M, Trostler N, Norenberg C (1988) Effects of cottonseed dietary fiber on metabolic
parameters in diabetic rats and non-insulin-dependent diabetic humans. J Nutr 118
(9):1143–1148
Mahmood F, Khan MZ, Khan A, Muhammad G, Javed I (2011) Lysine induced modulation of
toxico-pathological effects of cottonseed meal in broiler breeder males. Pak J Zool 43
(2):357–365
Manabe S, Nuber DC, Lin YC (1991) Zone-specific hepatotoxicity of gossypol in perfused rat liver.
Toxicon 29(6):787–790
Mellon JE, Zelaya CA, Dowd MK, Beltz SB, Klich MA (2012) Inhibitory effects of gossypol,
gossypolone, and apogossypolone on a collection of economically important filamentous fungi.
J Agric Food Chem 60(10):2740–2745
Mena H, Santos JEP, Huber JT, Tarazon M, Calhoun MC (2004) The effects of varying gossypol
intake from whole cottonseed and cottonseed meal on lactation and blood parameters in
lactating dairy cows. J Dairy Sci 87(8):2506–2518
Morgan S, Stair EL, Martin T, Edwards WC, Morgan GL (1988) Clinical, clinicopathologic,
pathologic, and toxicologic alterations associated with gossypol toxicosis in feeder lambs. Am
J Vet Res 49(4):493–499
Nagalakshmi D, Rao SVR, Panda AK, Sastry VR (2007) Cottonseed meal in poultry diets: a review.
J Poult Sci 44(2):119–134
Namuli A, Abdullah N, Sieo CC, Zuhainis SW, Oskoueian E (2011) Phytochemical compounds
and antibacterial activity of Jatropha curcas Linn. extracts. J Med Plant Res 5(16):3982–3990
O’Brien RD, Jones, LA, King CC, Wakelyn PJ, Wan PJ (2005) Cottonseed oil, In: Shahidi F
(ed) Bailey’s industrial oil and fat products, vol. 2, 6th edn. John Wiley & Sons, Inc., Hoboken,
NJ, pp. 173–279
Ory RL, Flick GJ (1994) Peanut and cottonseed proteins for food uses. In: Hudson BJF (ed) New
and developing sources of food proteins. Springer, Boston, MA, pp 195–240
Oskoueian E, Abdullah N, Hendra R, Karimi E (2011a) Bioactive compounds, antioxidant,
xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected
agro-industrial by-products. Int J Mol Sci 12(12):8610–8625
Oskoueian E, Abdullah N, Ahmad S, Saad WZ, Omar AR, Ho YW (2011b) Bioactive compounds
and biological activities of Jatropha curcas L. kernel meal extract. Int J Mol Sci 12
(9):5955–5970
90
M. K. Sihag et al.