114
M. Maden
MacLean G, Abu-Abed S, Dolle P, Tahayato A, Chambon P, Petkovich M (2001) Cloning of a novel
retinoic acid- metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis
with Cyp26A1 during early murine development. Mech Dev 107:195–201
Maden M (1978) Supernumerary limbs in the axolotl. Nature 273:232–235
Maden M (1982) Vitamin A and pattern formation in the regenerating limb. Nature 295:672–675
Maden M (1983a) The effect of vitamin A on the regenerating axolotl limb. J Embryol exp Morph
77:273–295
Maden M (1983b) The effect of vitamin A on limb regeneration in Rana temporaria. Dev Biol
98:409–416
Maden M (1993) The homeotic transformation of tails into limbs in Rana temporaria by retinoids.
Dev Biol 159:379–391
Maden M (1998) Retinoids as endogenous components of the regenerating limb and tail. Wound
Rep Regen. 6:358–365
Maden M, Sonneveld E, Van Der Saag PT, Gale E (1998) The distribution of retinoic acid in the
chick embryo: implications for developmental mechanisms. Development 125:4133–4144
Mandal A, Rydeen A, Anderson J, Sorrell MR, Zygmunt T, Torres-Vázquez J, Waxman JS (2013)
Transgenic retinoic acid sensor lines in zebrafish indicate regions of available embryonic retinoic
acid. Dev Dyn 242:989–1000
McEwan J, Lynch J, Beck CW (2011) Expression of key retinoic acid modulating genes suggests
active regulation during development and regeneration of the amphibian limb. Dev Dyn 240:1259–
1270
Mercarder N, Leonardo E, Peidra ME, Martinez-A C, Ros MA, Torres M (2000) Opposing RA
and FGF signals control proximodistal vertebrate limb development through regulation of Meis
genes. Development 127:3961–3970
Mercarder N, Fischer S, Neumann CJ (2006) Prdm1 acts downstream of a sequential RA, Wnt and
Fgf signaling cascade during zebrafish forelimb induction. Development 133:2805–2815
Mic FA, Sirbu IO, Duester G (2004) Retinoic acid synthesis controlled by Raldh2 is required early
for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge
formation. J Biol Chem 279:26698–26706
Mohanty-Heijmadi P, Dutta SK, Mahapatra P (1992) Limbs generated at site of tail amputation in
marbled balloon frog after vitamin A treatment. Nature 355:352–353
Monaghan JR, Maden M (2012) Visualization of retinoic acid signaling in transgenic axolotls during
limb development and regeneration. Dev Biol 368:63–75
Monaghan JR, Athippozy A, Seifert AW, Putta S, Stromberg A, Maden M, Gardiner DM, Voss SR
(2012) Gene expression patterns specific to the regenerating limb of the Mexican axolotl. Biol
Open 1:937–948
Morais da Silva S, Gates PB, Brockes JP (2002) The Newt Ortholog of CD59 Is Implicated in
Proximodistal Identity during Amphibian Limb Regeneration. Dev Cell 3:547–555
Morgan TH (1901) Regeneration. Macmillan New York, 1901
Nardi JB, Stocum DL (1983) Surface properties of regenerating limb cells: evidence for gradation
along the proximodistal axis. Differentiation 25:27–31
Neumann CJ, Grandel H, Gaffield W, Schulte-Merker S, Nusslein-Volhard C (1999) Transient
establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic
hedgehog activity. Development 126:4817–4826
Nguyen M, Singhal P, Piet J, Shefelbine SJ, Maden M, Voss AR, Monaghan JR (2017) Retinoic
acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl. Development
144:601–611
Niazi IA, Saxena S (1978) Abnormal hindlimb regeneration in tadpoles of the toad, Bufo andersonii,
exposed to excess vitamin A. Folia Biol (Krakow) 26:3–8
Niazi IA, Pescitelli MJ, Stocum DL (1985) Stage dependent effects of retinoic acid on regenerating
limbs. Wilhelm Roux Arch Dev Biol 194:355–363
Niederreither K, Subbarayan V, Dolle P, Chambon P (1999) Embryonic retinoic acid synthesis is
essential for early mouse post-embryonic development. Nat Genet 21:444–448
M. Maden
MacLean G, Abu-Abed S, Dolle P, Tahayato A, Chambon P, Petkovich M (2001) Cloning of a novel
retinoic acid- metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis
with Cyp26A1 during early murine development. Mech Dev 107:195–201
Maden M (1978) Supernumerary limbs in the axolotl. Nature 273:232–235
Maden M (1982) Vitamin A and pattern formation in the regenerating limb. Nature 295:672–675
Maden M (1983a) The effect of vitamin A on the regenerating axolotl limb. J Embryol exp Morph
77:273–295
Maden M (1983b) The effect of vitamin A on limb regeneration in Rana temporaria. Dev Biol
98:409–416
Maden M (1993) The homeotic transformation of tails into limbs in Rana temporaria by retinoids.
Dev Biol 159:379–391
Maden M (1998) Retinoids as endogenous components of the regenerating limb and tail. Wound
Rep Regen. 6:358–365
Maden M, Sonneveld E, Van Der Saag PT, Gale E (1998) The distribution of retinoic acid in the
chick embryo: implications for developmental mechanisms. Development 125:4133–4144
Mandal A, Rydeen A, Anderson J, Sorrell MR, Zygmunt T, Torres-Vázquez J, Waxman JS (2013)
Transgenic retinoic acid sensor lines in zebrafish indicate regions of available embryonic retinoic
acid. Dev Dyn 242:989–1000
McEwan J, Lynch J, Beck CW (2011) Expression of key retinoic acid modulating genes suggests
active regulation during development and regeneration of the amphibian limb. Dev Dyn 240:1259–
1270
Mercarder N, Leonardo E, Peidra ME, Martinez-A C, Ros MA, Torres M (2000) Opposing RA
and FGF signals control proximodistal vertebrate limb development through regulation of Meis
genes. Development 127:3961–3970
Mercarder N, Fischer S, Neumann CJ (2006) Prdm1 acts downstream of a sequential RA, Wnt and
Fgf signaling cascade during zebrafish forelimb induction. Development 133:2805–2815
Mic FA, Sirbu IO, Duester G (2004) Retinoic acid synthesis controlled by Raldh2 is required early
for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge
formation. J Biol Chem 279:26698–26706
Mohanty-Heijmadi P, Dutta SK, Mahapatra P (1992) Limbs generated at site of tail amputation in
marbled balloon frog after vitamin A treatment. Nature 355:352–353
Monaghan JR, Maden M (2012) Visualization of retinoic acid signaling in transgenic axolotls during
limb development and regeneration. Dev Biol 368:63–75
Monaghan JR, Athippozy A, Seifert AW, Putta S, Stromberg A, Maden M, Gardiner DM, Voss SR
(2012) Gene expression patterns specific to the regenerating limb of the Mexican axolotl. Biol
Open 1:937–948
Morais da Silva S, Gates PB, Brockes JP (2002) The Newt Ortholog of CD59 Is Implicated in
Proximodistal Identity during Amphibian Limb Regeneration. Dev Cell 3:547–555
Morgan TH (1901) Regeneration. Macmillan New York, 1901
Nardi JB, Stocum DL (1983) Surface properties of regenerating limb cells: evidence for gradation
along the proximodistal axis. Differentiation 25:27–31
Neumann CJ, Grandel H, Gaffield W, Schulte-Merker S, Nusslein-Volhard C (1999) Transient
establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic
hedgehog activity. Development 126:4817–4826
Nguyen M, Singhal P, Piet J, Shefelbine SJ, Maden M, Voss AR, Monaghan JR (2017) Retinoic
acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl. Development
144:601–611
Niazi IA, Saxena S (1978) Abnormal hindlimb regeneration in tadpoles of the toad, Bufo andersonii,
exposed to excess vitamin A. Folia Biol (Krakow) 26:3–8
Niazi IA, Pescitelli MJ, Stocum DL (1985) Stage dependent effects of retinoic acid on regenerating
limbs. Wilhelm Roux Arch Dev Biol 194:355–363
Niederreither K, Subbarayan V, Dolle P, Chambon P (1999) Embryonic retinoic acid synthesis is
essential for early mouse post-embryonic development. Nat Genet 21:444–448