93. Patil P, Mandal S, Tomar SK, Anand S (2015) Food protein-derived bioactive peptides in
management of type 2 diabetes. Eur J Nutr 54(6):863–880
94. Kehinde BA, Sharma P (2018) Recently isolated antidiabetic hydrolysates and peptides from
multiple food sources: a review. Crit Rev Food Sci Nutr 60(35):1–20
95. Power O, Nongonierma AB, Jakeman P, FitzGerald RJ (2014) Food protein hydrolysates as
a source of dipeptidyl peptidase IV inhibitory peptides for the management of type 2
diabetes. Proc Nutr Soc 73(1):34–46
96. Nongonierma AB, FitzGerald RJ (2014) Susceptibility of milk protein-derived peptides to
dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chem 145:845–852
97. Lacroix IM, Li-Chan EC (2014) Isolation and characterization of peptides with dipeptidyl
peptidase-IV inhibitory activity from pepsin-treated bovine whey proteins. Peptides 54:39–48
98. Tulipano G, Cocchi D, Caroli AM (2012) Comparison of goat and sheep beta-lactoglobulin
to bovine beta-lactoglobulin as potential source of dipeptidyl peptidase IV (DPP-4)
inhibitors. Int Dairy J 24(2):97–101
99. Lacroix IME, Li-Chan ECY (2012) Dipeptidyl peptidase-IV inhibitory activity of dairy
protein hydrolysates. Int Dairy J 25(2):97–102
100. Liu R, Cheng J, Wu H (2019) Discovery of food-derived dipeptidyl peptidase IV inhibitory
peptides: a review. Int J Mol Sci 20(3):463
101. Kahn SE, Cooper ME, Del Prato S (2014) Pathophysiology and treatment of type 2 diabetes:
perspectives on the past, present, and future. Lancet (London, England) 383(9922):
1068–1083
102. Konrad B, Anna D, Marek S, Marta P, Aleksandra Z, Józefa C (2014) The evaluation of
dipeptidyl peptidase (DPP)-IV, a-glucosidase and angiotensin converting enzyme (ACE) inhibitory activities of whey proteins hydrolyzed with serine protease isolated from Asian
pumpkin (Cucurbita ficifolia). Int J Pept Res Ther 20(4):483–491
103. Lacroix IME, Li-Chan ECY (2013) Inhibition of dipeptidyl peptidase (DPP)-IV and
a-glucosidase activities by pepsin-treated whey proteins. J Agric Food Chem 61(31):7500–7506
104. Wang R, Zhao H, Pan X, Orfila C, Lu W, Ma Y (2019) Preparation of bioactive peptides
with antidiabetic, antihypertensive, and antioxidant activities and identification of
a-glucosidase inhibitory peptides. Food Sci Nutr 7:1848–1856
105. Bougatef A, Nedjar-Arroume N, Ravallec-Plé R, Leroy Y, Guillochon D, Barkia A, Nasri M
(2008) Angiotensin I-converting enzyme (ACE) inhibitory activities of sardinelle (Sardinella
aurita) by-products protein hydrolysates obtained by treatment with microbial and visceral
fish serine proteases. Food Chem 111(2):350–356
106. Pihlanto-Leppälä A (2000) Bioactive peptides derived from bovine whey proteins: opioid
and ACE-inhibitory peptides. Trends Food Sci Technol 11(9–10):347–356
107. Pan D, Cao J, Guo H, Zhao B (2012) Studies on purification and the molecular mechanism
of a novel ACE inhibitory peptide from whey protein hydrolysate. Food Chem 130(1):
121–126
108. García-Mora P, Martín-Martínez M, Bonache MA, González-Múniz R, Peñas E, Frias J,
Martinez-Villaluenga C (2017) Identification, functional gastrointestinal stability and
molecular docking studies of Lentil peptides with dual antioxidant and AngiotensinI
converting enzyme inhibitory peptides. Food Chem 221:464–472
109. Daliri EB-M, Lee BH, Park B-J, Kim S-H, Oh D-H (2018) Antihypertensive peptides from
whey proteins fermented by lactic acid bacteria. Food Sci Biotechnol 27(6):1781–1789
110. Sah BNP, Vasiljevic T, McKechnie S, Donkor ON (2017) Antioxidative and antibacterial
peptides derived from bovine milk proteins. Crit Rev Food Sci Nutrition 58(5):726–740
111. Yeaman MR, Yount NY (2003) Mechanisms of antimicrobial peptide action and resistance.
Pharmacol Rev 55(1):27–55
112. Choi H, Lee DG (2012) Synergistic effect of antimicrobial peptide arenicin-1 in combination
with antibiotics against pathogenic bacteria. Res Microbiol 163(6–7):479–486
504
A. F. A. Salvado et al.
management of type 2 diabetes. Eur J Nutr 54(6):863–880
94. Kehinde BA, Sharma P (2018) Recently isolated antidiabetic hydrolysates and peptides from
multiple food sources: a review. Crit Rev Food Sci Nutr 60(35):1–20
95. Power O, Nongonierma AB, Jakeman P, FitzGerald RJ (2014) Food protein hydrolysates as
a source of dipeptidyl peptidase IV inhibitory peptides for the management of type 2
diabetes. Proc Nutr Soc 73(1):34–46
96. Nongonierma AB, FitzGerald RJ (2014) Susceptibility of milk protein-derived peptides to
dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chem 145:845–852
97. Lacroix IM, Li-Chan EC (2014) Isolation and characterization of peptides with dipeptidyl
peptidase-IV inhibitory activity from pepsin-treated bovine whey proteins. Peptides 54:39–48
98. Tulipano G, Cocchi D, Caroli AM (2012) Comparison of goat and sheep beta-lactoglobulin
to bovine beta-lactoglobulin as potential source of dipeptidyl peptidase IV (DPP-4)
inhibitors. Int Dairy J 24(2):97–101
99. Lacroix IME, Li-Chan ECY (2012) Dipeptidyl peptidase-IV inhibitory activity of dairy
protein hydrolysates. Int Dairy J 25(2):97–102
100. Liu R, Cheng J, Wu H (2019) Discovery of food-derived dipeptidyl peptidase IV inhibitory
peptides: a review. Int J Mol Sci 20(3):463
101. Kahn SE, Cooper ME, Del Prato S (2014) Pathophysiology and treatment of type 2 diabetes:
perspectives on the past, present, and future. Lancet (London, England) 383(9922):
1068–1083
102. Konrad B, Anna D, Marek S, Marta P, Aleksandra Z, Józefa C (2014) The evaluation of
dipeptidyl peptidase (DPP)-IV, a-glucosidase and angiotensin converting enzyme (ACE) inhibitory activities of whey proteins hydrolyzed with serine protease isolated from Asian
pumpkin (Cucurbita ficifolia). Int J Pept Res Ther 20(4):483–491
103. Lacroix IME, Li-Chan ECY (2013) Inhibition of dipeptidyl peptidase (DPP)-IV and
a-glucosidase activities by pepsin-treated whey proteins. J Agric Food Chem 61(31):7500–7506
104. Wang R, Zhao H, Pan X, Orfila C, Lu W, Ma Y (2019) Preparation of bioactive peptides
with antidiabetic, antihypertensive, and antioxidant activities and identification of
a-glucosidase inhibitory peptides. Food Sci Nutr 7:1848–1856
105. Bougatef A, Nedjar-Arroume N, Ravallec-Plé R, Leroy Y, Guillochon D, Barkia A, Nasri M
(2008) Angiotensin I-converting enzyme (ACE) inhibitory activities of sardinelle (Sardinella
aurita) by-products protein hydrolysates obtained by treatment with microbial and visceral
fish serine proteases. Food Chem 111(2):350–356
106. Pihlanto-Leppälä A (2000) Bioactive peptides derived from bovine whey proteins: opioid
and ACE-inhibitory peptides. Trends Food Sci Technol 11(9–10):347–356
107. Pan D, Cao J, Guo H, Zhao B (2012) Studies on purification and the molecular mechanism
of a novel ACE inhibitory peptide from whey protein hydrolysate. Food Chem 130(1):
121–126
108. García-Mora P, Martín-Martínez M, Bonache MA, González-Múniz R, Peñas E, Frias J,
Martinez-Villaluenga C (2017) Identification, functional gastrointestinal stability and
molecular docking studies of Lentil peptides with dual antioxidant and AngiotensinI
converting enzyme inhibitory peptides. Food Chem 221:464–472
109. Daliri EB-M, Lee BH, Park B-J, Kim S-H, Oh D-H (2018) Antihypertensive peptides from
whey proteins fermented by lactic acid bacteria. Food Sci Biotechnol 27(6):1781–1789
110. Sah BNP, Vasiljevic T, McKechnie S, Donkor ON (2017) Antioxidative and antibacterial
peptides derived from bovine milk proteins. Crit Rev Food Sci Nutrition 58(5):726–740
111. Yeaman MR, Yount NY (2003) Mechanisms of antimicrobial peptide action and resistance.
Pharmacol Rev 55(1):27–55
112. Choi H, Lee DG (2012) Synergistic effect of antimicrobial peptide arenicin-1 in combination
with antibiotics against pathogenic bacteria. Res Microbiol 163(6–7):479–486
504
A. F. A. Salvado et al.