113. Seo MD, Won HS, Kim JH, Mishig-Ochir T, Lee BJ (2012) Antimicrobial peptides for
therapeutic applications: a review. Molecules 17(10):12276–12286
114. Théolier J, Fliss I, Jean J, Hammami R (2014) Antimicrobial peptides of dairy proteins: from
fundamental to applications. Food Rev Int 30(2):134–154
115. Demers-Mathieu V, Gauthier SF, Britten M, Fliss I, Robitaille G, Jean J (2013) Antibacterial
activity of peptides extracted from tryptic hydrolyzate of whey protein by nanofiltration. Int
Dairy J 28(2):94–101
116. Théolier J, Hammami R, Labelle P, Fliss I, Jean J (2013) Isolation and identification of
antimicrobial peptides derived by peptic cleavage of whey protein isolate. J Funct Foods 5
(2):706–714
117. Kamau SM, Lu RR, Chen W, Liu XM, Tian FW, Shen Y, Gao T (2010) Functional
significance of bioactive peptides derived from milk proteins. Food Rev Int 26(4):386–401
118. Mohanty D, Jena R, Choudhury PK, Pattnaik R, Mohapatra M, Saini MR (2016) Milk
derived antimicrobial bioactive peptides: a review. Int J Food Prop 19(4):837–846
119. Zhang J, Zhang H, Wang L, Guo X, Wang X, Yao H (2009) Antioxidant activities of the rice
endosperm protein hydrolysate: identification of the active peptide. Eur Food Res Technol
229(4):709–719
120. Conway V, Gauthier SF, Pouliot Y (2013) Antioxidant activities of buttermilk proteins,
whey proteins, and their enzymatic hydrolysates. J Agric Food Chem 61(2):364–372
121. Sadat L, Cakir-Kiefer C, N’Negue MA, Gaillard JL, Girardet JM, Miclo L (2011) Isolation
and identification of antioxidative peptides from bovine a-lactalbumin. Int Dairy J 21
(4):214–221
122. Contreras MM, Hernández-Ledesma B, Amigo L, Martín-Álvarez PJ, Recio I (2011)
Production of antioxidant hydrolyzates from a whey protein concentrate with thermolysin:
optimization by response surface methodology. LWT—Food Sci Tech 44(1):9–15
123. Hernández-Ledesma B, Amigo L, Recio I, Bartolomé B (2007) ACE-inhibitory and
radical-scavenging activity of peptides derived from beta-lactoglobulin f(19–25). Interactions with ascorbic acid. J Agric Food Chem 55(9):3392–3397
124. Jiang B, Zhang X, Yuan Y, Qu Y, Feng Z (2017) Separation of antioxidant peptides from
pepsin hydrolysate of whey protein isolate by ATPS of EOPO copolymer (UCON)/
Phosphate. Sci Rep 7(1):13320
125. Zhou DY, Zhu BW, Qiao L, Wu HT, Li DM, Yang JF, Murata Y (2012) In vitro antioxidant
activity of enzymatic hydrolysates prepared from abalone (Haliotis discus hannai Ino)
viscera. Food Bioprod Process 90(2):148–154
126. Corrochano AR, Buckin V, Kelly PM, Giblin L (2018) Invited review: whey proteins as
antioxidants and promoters of cellular antioxidant pathways. J Dairy Sci 101(6):4747–4761
127. Santiago-López L, Hernández-Mendoza A, Vallejo-Cordoba B, Mata-Haro V, González-Córdova A (2016) Food-derived immunomodulatory peptides. J Sci Food Agric 96
(11):3631–3641
128. Gauthier SF, Pouliot Y, Saint-Sauveur D (2006) Immunomodulatory peptides obtained by
the enzymatic hydrolysis of whey proteins. Int Dairy J 16(11):1315–1323
129. Wu W, Zhang M, Sun C, Brennan M, Li H, Wang G, Lai F, Wu H (2016) Enzymatic
preparation of immunomodulatory hydrolysates from defatted wheat germ (Triticum
vulgare) globulin. Int J Food Sci Tech 51(12):2556–2566
130. Jacquot A, Gauthier SF, Drouin R, Boutin Y (2010) Proliferative effects of synthetic
peptides from b-lactoglobulin and a-lactalbumin on murine splenocytes. Int Dairy J 20
(8):514–521
131. Kiewiet MBG, Faas MM, de Vos P (2018) Immunomodulatory protein hydrolysates and
their application. Nutrients 10(7):904–926
132. Kostyra E, Sienkiewicz-Szlapka E, Jarmolowska B, Krawczuk S, Kostyra H (2004) Opioid
peptides derived from milk proteins. Polish J Food Nutr Sci 13(Suppl. 1):25–35
Enzymatic Production of Bioactive Peptides from Whey Proteins …
505
therapeutic applications: a review. Molecules 17(10):12276–12286
114. Théolier J, Fliss I, Jean J, Hammami R (2014) Antimicrobial peptides of dairy proteins: from
fundamental to applications. Food Rev Int 30(2):134–154
115. Demers-Mathieu V, Gauthier SF, Britten M, Fliss I, Robitaille G, Jean J (2013) Antibacterial
activity of peptides extracted from tryptic hydrolyzate of whey protein by nanofiltration. Int
Dairy J 28(2):94–101
116. Théolier J, Hammami R, Labelle P, Fliss I, Jean J (2013) Isolation and identification of
antimicrobial peptides derived by peptic cleavage of whey protein isolate. J Funct Foods 5
(2):706–714
117. Kamau SM, Lu RR, Chen W, Liu XM, Tian FW, Shen Y, Gao T (2010) Functional
significance of bioactive peptides derived from milk proteins. Food Rev Int 26(4):386–401
118. Mohanty D, Jena R, Choudhury PK, Pattnaik R, Mohapatra M, Saini MR (2016) Milk
derived antimicrobial bioactive peptides: a review. Int J Food Prop 19(4):837–846
119. Zhang J, Zhang H, Wang L, Guo X, Wang X, Yao H (2009) Antioxidant activities of the rice
endosperm protein hydrolysate: identification of the active peptide. Eur Food Res Technol
229(4):709–719
120. Conway V, Gauthier SF, Pouliot Y (2013) Antioxidant activities of buttermilk proteins,
whey proteins, and their enzymatic hydrolysates. J Agric Food Chem 61(2):364–372
121. Sadat L, Cakir-Kiefer C, N’Negue MA, Gaillard JL, Girardet JM, Miclo L (2011) Isolation
and identification of antioxidative peptides from bovine a-lactalbumin. Int Dairy J 21
(4):214–221
122. Contreras MM, Hernández-Ledesma B, Amigo L, Martín-Álvarez PJ, Recio I (2011)
Production of antioxidant hydrolyzates from a whey protein concentrate with thermolysin:
optimization by response surface methodology. LWT—Food Sci Tech 44(1):9–15
123. Hernández-Ledesma B, Amigo L, Recio I, Bartolomé B (2007) ACE-inhibitory and
radical-scavenging activity of peptides derived from beta-lactoglobulin f(19–25). Interactions with ascorbic acid. J Agric Food Chem 55(9):3392–3397
124. Jiang B, Zhang X, Yuan Y, Qu Y, Feng Z (2017) Separation of antioxidant peptides from
pepsin hydrolysate of whey protein isolate by ATPS of EOPO copolymer (UCON)/
Phosphate. Sci Rep 7(1):13320
125. Zhou DY, Zhu BW, Qiao L, Wu HT, Li DM, Yang JF, Murata Y (2012) In vitro antioxidant
activity of enzymatic hydrolysates prepared from abalone (Haliotis discus hannai Ino)
viscera. Food Bioprod Process 90(2):148–154
126. Corrochano AR, Buckin V, Kelly PM, Giblin L (2018) Invited review: whey proteins as
antioxidants and promoters of cellular antioxidant pathways. J Dairy Sci 101(6):4747–4761
127. Santiago-López L, Hernández-Mendoza A, Vallejo-Cordoba B, Mata-Haro V, González-Córdova A (2016) Food-derived immunomodulatory peptides. J Sci Food Agric 96
(11):3631–3641
128. Gauthier SF, Pouliot Y, Saint-Sauveur D (2006) Immunomodulatory peptides obtained by
the enzymatic hydrolysis of whey proteins. Int Dairy J 16(11):1315–1323
129. Wu W, Zhang M, Sun C, Brennan M, Li H, Wang G, Lai F, Wu H (2016) Enzymatic
preparation of immunomodulatory hydrolysates from defatted wheat germ (Triticum
vulgare) globulin. Int J Food Sci Tech 51(12):2556–2566
130. Jacquot A, Gauthier SF, Drouin R, Boutin Y (2010) Proliferative effects of synthetic
peptides from b-lactoglobulin and a-lactalbumin on murine splenocytes. Int Dairy J 20
(8):514–521
131. Kiewiet MBG, Faas MM, de Vos P (2018) Immunomodulatory protein hydrolysates and
their application. Nutrients 10(7):904–926
132. Kostyra E, Sienkiewicz-Szlapka E, Jarmolowska B, Krawczuk S, Kostyra H (2004) Opioid
peptides derived from milk proteins. Polish J Food Nutr Sci 13(Suppl. 1):25–35
Enzymatic Production of Bioactive Peptides from Whey Proteins …
505