73. Coutte F, Lecouturier D, Firdaous L, Kapel R, Bazinet L, Cabassud C, Dhulster P (2017)
Recent rends in membrane bioreactors. In: Pandey A, Larroche C, Soccol C (eds) Current
developments in biotechnology and bioengineering. Elsevier, Amsterdam, pp 279–311
74. Mundi S, Aluko RE (2014) Inhibitory properties of kidney bean protein hydrolysate and its
membrane fractions against renin, angiotensin converting enzyme, and free radicals. Austin J
Nutri Food Sci 2(1):1–11
75. Arrutia F, Rubio R, Riera FA (2016) Production and membrane fractionation of bioactive
peptides from a whey protein concentrate. J Food Eng 184:1–9
76. Doyen A, Udenigwe CC, Mitchell PL, Marette A, Aluko RE, Bazinet L (2014) Anti-diabetic
and antihypertensive activities of two flaxseed protein hydrolysate fractions revealed
following their simultaneous separation by electrodialysis with ultrafiltration membranes.
Food Chem 145:66–76
77. Holder A, Merath C, Kulozik U, Hinrichs J (2015) Impact of diffusion, transmembrane
pressure and the electrical field on peptide fractionation using cross-flow electro membrane
filtration. Int Dairy J 46:31–38
78. Adebiyi AP, Adebiyi AO, Yamashita J, Ogawa T, Muramoto K (2008) Purification and
characterization of antioxidative peptides from unfractionated rice bran protein hydrolysates.
Inter J Food Sci Technol 43:35–43
79. Salvado AFA (2015) A comparative study between the correlation of the in silico and
in vitro hydrolysis of whey proteins. M.Sc. thesis, Instituto Superior Técnico, University of
Lisbon
80. Leeb E, Holder A, Letzel T, Cheison SC, Kulozik U, Hinrichs J (2014) Fractionation of
dairy based functional peptides using ion-exchange membrane adsorption chromatography
and cross-flow electro membrane filtration. Int Dairy J 38(2):116–123
81. Hippauf F, Lunow D, Borchardt L, Henle T, Kaskel S (2014) Extraction of ACE inhibiting
dipeptides from protein hydrolysates using porous carbon materials. Carbon 77:191–198
82. Bhut BV, Weaver J, Carter AR, Wickramasinghe SR, Husson SM (2011) The role of
polymer nanolayer architecture on the separation performance of anion-exchange membrane
adsorbers: I. Protein separations. Biotechnol Bioeng 108(11):2645–2653
83. Saiga A, Tanabe S, Nishimura T (2003) Antioxidant activity of peptides obtained from
porcine myofibrillar proteins by protease treatment. J Agric Food Chem 51:3661–3667
84. Mann B, Athira S, Sharma R, Kumar R, Sarkar P (2019) Bioactive peptides from whey
proteins. In: Deeth HC, Bansad N (eds) Whey proteins—from milk to medicine. Academic,
London, pp 519–547
85. Barras D, Widmann C (2011) Promises of apoptosis-inducing peptides in cancer
therapeutics. Curr Pharm Biotechnol 12(8):1153–1165
86. Pepe G, Tenore GC, Mastrocinque R, Stusio P, Campiglia P (2013) Potential anticarcinogenic peptides from bovine milk. J Amino Acids 2013:1–7
87. Mader JS, Salsman J, Conrad DM, Hoskin DW (2005) Bovine lactoferricin selectively induces
apoptosis in human leukemia and carcinoma cell lines. Mol Cancer Ther 4(4):612–624
88. Chen W, Ding H, Feng P, Lin H, Chou KC (2016) IACP: a sequence-based tool for
identifying anticancer peptides. Oncotarget 7(13):16895
89. Gabernet G, Müller AT, Hiss JA, Schneider G (2016) Membranolytic anticancer peptides.
Med Chem Commun 7(12):2232–2245
90. Chalamaiah M, Yu W, Wu J (2018) Immunomodulatory and anticancer protein hydrolysates
(peptides) from food proteins: a review. Food Chem 245:205–222
91. Gaudel C, Nongonierma AB, Maher S, Flynn S, Krause M, Murray BA, Kelly PM,
Baird AW, FitzGerald RJ, Newsholme PA (2013) Whey protein hydrolysate promotes
insulinotropic activity in a clonal pancreatic b-cell line and enhances glycemic function in
ob/ob mice. J Nutr 143(7):1109–1114
92. Nongonierma AB, Gaudel C, Murray BA, Flynn S, Kelly PM, Newsholme P, FitzGerald RJ
(2013) Insulinotropic properties of whey protein hydrolysates and impact of peptide
fractionation on insulinotropic response. Int Dairy J 32(2):163–168
Enzymatic Production of Bioactive Peptides from Whey Proteins …
503
Recent rends in membrane bioreactors. In: Pandey A, Larroche C, Soccol C (eds) Current
developments in biotechnology and bioengineering. Elsevier, Amsterdam, pp 279–311
74. Mundi S, Aluko RE (2014) Inhibitory properties of kidney bean protein hydrolysate and its
membrane fractions against renin, angiotensin converting enzyme, and free radicals. Austin J
Nutri Food Sci 2(1):1–11
75. Arrutia F, Rubio R, Riera FA (2016) Production and membrane fractionation of bioactive
peptides from a whey protein concentrate. J Food Eng 184:1–9
76. Doyen A, Udenigwe CC, Mitchell PL, Marette A, Aluko RE, Bazinet L (2014) Anti-diabetic
and antihypertensive activities of two flaxseed protein hydrolysate fractions revealed
following their simultaneous separation by electrodialysis with ultrafiltration membranes.
Food Chem 145:66–76
77. Holder A, Merath C, Kulozik U, Hinrichs J (2015) Impact of diffusion, transmembrane
pressure and the electrical field on peptide fractionation using cross-flow electro membrane
filtration. Int Dairy J 46:31–38
78. Adebiyi AP, Adebiyi AO, Yamashita J, Ogawa T, Muramoto K (2008) Purification and
characterization of antioxidative peptides from unfractionated rice bran protein hydrolysates.
Inter J Food Sci Technol 43:35–43
79. Salvado AFA (2015) A comparative study between the correlation of the in silico and
in vitro hydrolysis of whey proteins. M.Sc. thesis, Instituto Superior Técnico, University of
Lisbon
80. Leeb E, Holder A, Letzel T, Cheison SC, Kulozik U, Hinrichs J (2014) Fractionation of
dairy based functional peptides using ion-exchange membrane adsorption chromatography
and cross-flow electro membrane filtration. Int Dairy J 38(2):116–123
81. Hippauf F, Lunow D, Borchardt L, Henle T, Kaskel S (2014) Extraction of ACE inhibiting
dipeptides from protein hydrolysates using porous carbon materials. Carbon 77:191–198
82. Bhut BV, Weaver J, Carter AR, Wickramasinghe SR, Husson SM (2011) The role of
polymer nanolayer architecture on the separation performance of anion-exchange membrane
adsorbers: I. Protein separations. Biotechnol Bioeng 108(11):2645–2653
83. Saiga A, Tanabe S, Nishimura T (2003) Antioxidant activity of peptides obtained from
porcine myofibrillar proteins by protease treatment. J Agric Food Chem 51:3661–3667
84. Mann B, Athira S, Sharma R, Kumar R, Sarkar P (2019) Bioactive peptides from whey
proteins. In: Deeth HC, Bansad N (eds) Whey proteins—from milk to medicine. Academic,
London, pp 519–547
85. Barras D, Widmann C (2011) Promises of apoptosis-inducing peptides in cancer
therapeutics. Curr Pharm Biotechnol 12(8):1153–1165
86. Pepe G, Tenore GC, Mastrocinque R, Stusio P, Campiglia P (2013) Potential anticarcinogenic peptides from bovine milk. J Amino Acids 2013:1–7
87. Mader JS, Salsman J, Conrad DM, Hoskin DW (2005) Bovine lactoferricin selectively induces
apoptosis in human leukemia and carcinoma cell lines. Mol Cancer Ther 4(4):612–624
88. Chen W, Ding H, Feng P, Lin H, Chou KC (2016) IACP: a sequence-based tool for
identifying anticancer peptides. Oncotarget 7(13):16895
89. Gabernet G, Müller AT, Hiss JA, Schneider G (2016) Membranolytic anticancer peptides.
Med Chem Commun 7(12):2232–2245
90. Chalamaiah M, Yu W, Wu J (2018) Immunomodulatory and anticancer protein hydrolysates
(peptides) from food proteins: a review. Food Chem 245:205–222
91. Gaudel C, Nongonierma AB, Maher S, Flynn S, Krause M, Murray BA, Kelly PM,
Baird AW, FitzGerald RJ, Newsholme PA (2013) Whey protein hydrolysate promotes
insulinotropic activity in a clonal pancreatic b-cell line and enhances glycemic function in
ob/ob mice. J Nutr 143(7):1109–1114
92. Nongonierma AB, Gaudel C, Murray BA, Flynn S, Kelly PM, Newsholme P, FitzGerald RJ
(2013) Insulinotropic properties of whey protein hydrolysates and impact of peptide
fractionation on insulinotropic response. Int Dairy J 32(2):163–168
Enzymatic Production of Bioactive Peptides from Whey Proteins …
503