44
Ie. V. Pylypchuk et al.
Fig. 2.7 Scheme of a Fe 3 O 4 /H£/PA/DTPA/Gd 3+ NC formation
2.1 Conclusions
The processes of a DR adsorption of the surface of a Fe 3 O 4 /H£ NC from the
solution in a physiological fluid were studied. It was discovered that an increase
in an equilibrium concentration of DR does not lead to a saturated adsorption on the
surface of a Fe 3 O 4 /H£ adsorbent. It was found that the release of DR into saline
solution decreased as its quantity of the NC surface has been increased.
Magnetosensitive Fe 3 O 4 /H£/DR NCs were synthesized. It was found that a
cytotoxic effect and an antiproliferative activity of NCs in relation to Saccharomyces
cerevisiae cells are typical of an interaction of the mentioned cells with doxorubicin
in free form.
The ferrofluids containing Fe 3 O 4 /H£/DR NC stabilized by sodium oleate and
polyethylene glycol were produced and studied. By using an assembly of Fe 3 O 4
carriers as a superparamagnetic probe, the Langevin theory of paramagnetism, and
the density values of nanocomposite components, the parameters of their shells
were assessed, which are confirmed by independent measurements of the specific
surface area of nanostructures and the kinetic stability of respective ferrofluids.
The obtained results can be used for development of new forms of magnetocontrolled targeted delivery drugs and adsorbents on the basis of nanocomposites
of a superparamagnetic core-shell type with a multilevel nano-architecture and for
determination, control, and optimization of size parameters of its components.
It was found that an FF on the basis of a Fe 3 O 4 /H£ NC and cisplatin is
characterized by a cytotoxic activity in relation to cells with a drug resistance
Ie. V. Pylypchuk et al.
Fig. 2.7 Scheme of a Fe 3 O 4 /H£/PA/DTPA/Gd 3+ NC formation
2.1 Conclusions
The processes of a DR adsorption of the surface of a Fe 3 O 4 /H£ NC from the
solution in a physiological fluid were studied. It was discovered that an increase
in an equilibrium concentration of DR does not lead to a saturated adsorption on the
surface of a Fe 3 O 4 /H£ adsorbent. It was found that the release of DR into saline
solution decreased as its quantity of the NC surface has been increased.
Magnetosensitive Fe 3 O 4 /H£/DR NCs were synthesized. It was found that a
cytotoxic effect and an antiproliferative activity of NCs in relation to Saccharomyces
cerevisiae cells are typical of an interaction of the mentioned cells with doxorubicin
in free form.
The ferrofluids containing Fe 3 O 4 /H£/DR NC stabilized by sodium oleate and
polyethylene glycol were produced and studied. By using an assembly of Fe 3 O 4
carriers as a superparamagnetic probe, the Langevin theory of paramagnetism, and
the density values of nanocomposite components, the parameters of their shells
were assessed, which are confirmed by independent measurements of the specific
surface area of nanostructures and the kinetic stability of respective ferrofluids.
The obtained results can be used for development of new forms of magnetocontrolled targeted delivery drugs and adsorbents on the basis of nanocomposites
of a superparamagnetic core-shell type with a multilevel nano-architecture and for
determination, control, and optimization of size parameters of its components.
It was found that an FF on the basis of a Fe 3 O 4 /H£ NC and cisplatin is
characterized by a cytotoxic activity in relation to cells with a drug resistance