2 Multifunctional Magnetic Nanocomposites on the Base of Magnetite. . .
45
phenotype and is not more toxic than the official antineoplastic drug cisplatin,
which is indicative of perspectivity of its use for pathogenetically grounded targeted
therapy of malignant neoplasms.
Fe 3 O 4 /H£ NCs can be used for the creation of the newest magnetosensitive
theranostic drugs for neutron capture oncotherapy. Claimed use of a biomimetic
approach for coating the surface of nano-sized magnetite with hydroxyapatite is
given.
Acknowledgments The work was carried out with the support of the target comprehensive
program of fundamental research of the National Academy of Sciences of Ukraine “Fundamental
problems of the creation of new nanomaterials and nanotechnologies” for 2015–2019 (Project No.
38/17-n). The publication contains the results of research conducted with the grant support of the
State Fund for Fundamental Research (project 31566).
References
1. Abramov N (2014) Magnetic fluid on the basis of doxorubicin for the application in oncology.
Surface 6(21):241–258
2. Abramov N, Turanska S, Kusyak A, Petranovska A, Gorbyk P (2016) Synthesis and properties
of magnetite/hydroxyapatite/doxorubicin nanocomposites and magnetic liquids based on them.
J Nanostruct Chem 6:223–233
3. Anirudhan T, Sandeep S (2012) Synthesis, characterization, cellular uptake and cytotoxicity of
a multi-functional magnetic nanocomposite for the targeted delivery and controlled release of
doxorubicin to cancer cells. J Mater Chem 22:12888–12899
4. Bellin M-F (2006) MR contrast agents, the old and the new. Eur J Radiol 60:314–323
5. Caravan P (2006) Strategies for increasing the sensitivity of gadolinium based MRI contrast
agents. Chem Soc Rev 35:512–523
6. Chen F, Li C, Zhu Y-J, Zhao X-Y, Lu B-Q, Wu J (2013) Magnetic nanocomposite of hydroxyapatite ultrathin nanosheets/Fe 3 O 4 nanoparticles: microwave-assisted rapid synthesis and
application in pH-responsive drug release. Biomater Sci 1:1074–1081
7. Davaran S, Alimirzalu S, Nejati-Koshki K, Nasrabadi HT, Akbarzadeh A, Khandaghi AA,
Abbasian M, Alimohammadi S (2014) Physicochemical characteristics of Fe. Asian Pac J
Cancer Prev 15:49–54
8. Fukumori Y, Ichikawa H (2006) Nanoparticles for cancer therapy and diagnosis. Adv Powder
Technol 17:1–28
9. Gopi D, Ansari MT, Shinyjoy E, Kavitha L (2012) Synthesis and spectroscopic characterization
of magnetic hydroxyapatite nanocomposite using ultrasonic irradiation. Spectrochim Acta A
Mol Biomol Spectrosc 87:245–250
10. Gorbyk P (2013) Nanocomposites with medico-biological properties: synthesis, properties and
application. Nanosyst Nanomater Nanotechnol 11:323–436
11. Gorbyk P, Chekhun V, Vovk R, Nazyrov Z, Kruglyak V, Ogrin F, Edelman I, Malakhovskii A,
Sokolov A, Sukhachev A (2012) Nanocomposites of medicobiologic destination: reality and
perspectives for oncology. Funct Mater 19:145
12. Gorbyk P, Lerman L, Petranovska A & Turanska S (2014) Magnetosensitive nanocomposites
with functions of medico-biological nanorobots: synthesis and properties. In book: Advances
in Semiconductor Research: Physics of Nanosystems, Spintronics and Technological Applications. 161–198
13. Gorbyk, P., Petranovska, A., Usov, D. & Storozhuk, L. 2012. Nanocapsule with nanorobots
function. Patent of Ukraine
45
phenotype and is not more toxic than the official antineoplastic drug cisplatin,
which is indicative of perspectivity of its use for pathogenetically grounded targeted
therapy of malignant neoplasms.
Fe 3 O 4 /H£ NCs can be used for the creation of the newest magnetosensitive
theranostic drugs for neutron capture oncotherapy. Claimed use of a biomimetic
approach for coating the surface of nano-sized magnetite with hydroxyapatite is
given.
Acknowledgments The work was carried out with the support of the target comprehensive
program of fundamental research of the National Academy of Sciences of Ukraine “Fundamental
problems of the creation of new nanomaterials and nanotechnologies” for 2015–2019 (Project No.
38/17-n). The publication contains the results of research conducted with the grant support of the
State Fund for Fundamental Research (project 31566).
References
1. Abramov N (2014) Magnetic fluid on the basis of doxorubicin for the application in oncology.
Surface 6(21):241–258
2. Abramov N, Turanska S, Kusyak A, Petranovska A, Gorbyk P (2016) Synthesis and properties
of magnetite/hydroxyapatite/doxorubicin nanocomposites and magnetic liquids based on them.
J Nanostruct Chem 6:223–233
3. Anirudhan T, Sandeep S (2012) Synthesis, characterization, cellular uptake and cytotoxicity of
a multi-functional magnetic nanocomposite for the targeted delivery and controlled release of
doxorubicin to cancer cells. J Mater Chem 22:12888–12899
4. Bellin M-F (2006) MR contrast agents, the old and the new. Eur J Radiol 60:314–323
5. Caravan P (2006) Strategies for increasing the sensitivity of gadolinium based MRI contrast
agents. Chem Soc Rev 35:512–523
6. Chen F, Li C, Zhu Y-J, Zhao X-Y, Lu B-Q, Wu J (2013) Magnetic nanocomposite of hydroxyapatite ultrathin nanosheets/Fe 3 O 4 nanoparticles: microwave-assisted rapid synthesis and
application in pH-responsive drug release. Biomater Sci 1:1074–1081
7. Davaran S, Alimirzalu S, Nejati-Koshki K, Nasrabadi HT, Akbarzadeh A, Khandaghi AA,
Abbasian M, Alimohammadi S (2014) Physicochemical characteristics of Fe. Asian Pac J
Cancer Prev 15:49–54
8. Fukumori Y, Ichikawa H (2006) Nanoparticles for cancer therapy and diagnosis. Adv Powder
Technol 17:1–28
9. Gopi D, Ansari MT, Shinyjoy E, Kavitha L (2012) Synthesis and spectroscopic characterization
of magnetic hydroxyapatite nanocomposite using ultrasonic irradiation. Spectrochim Acta A
Mol Biomol Spectrosc 87:245–250
10. Gorbyk P (2013) Nanocomposites with medico-biological properties: synthesis, properties and
application. Nanosyst Nanomater Nanotechnol 11:323–436
11. Gorbyk P, Chekhun V, Vovk R, Nazyrov Z, Kruglyak V, Ogrin F, Edelman I, Malakhovskii A,
Sokolov A, Sukhachev A (2012) Nanocomposites of medicobiologic destination: reality and
perspectives for oncology. Funct Mater 19:145
12. Gorbyk P, Lerman L, Petranovska A & Turanska S (2014) Magnetosensitive nanocomposites
with functions of medico-biological nanorobots: synthesis and properties. In book: Advances
in Semiconductor Research: Physics of Nanosystems, Spintronics and Technological Applications. 161–198
13. Gorbyk, P., Petranovska, A., Usov, D. & Storozhuk, L. 2012. Nanocapsule with nanorobots
function. Patent of Ukraine