426
98. Liu YJ, Liu YH, Zhang ZZ, Yan SY, Chen K, Shi BF (2016) Divergent and stereoselective
synthesis of β-silyl-α-amino acids through palladium-catalyzed intermolecular silylation of
unactivated primary and secondary C-H bonds. Angew Chem Int Ed 55:13859–13862
99. Pan JL, Li QZ, Zhang TY, Hou SH, Kang JC, Zhang SY (2016) Palladium-catalyzed
direct intermolecular silylation of remote unactivated C(sp
3
)–H bonds. Chem Commun
52:13151–13154
100. Deb A, Singh S, Seth K, Pimparkar S, Bhaskararao B, Guin S, Sunoj RB, Maiti D (2017)
Experimental and computational studies on remote γ-C(sp
3
)–H silylation and germanylation
of aliphatic carboxamides. ACS Catal 7:8171–8175
101. Wheelaghan OR, Ortuño MA, Díez J, Garrido SEG, Maya C, Lledos A, Conejero S
(2012) Characterization of a paramagnetic, mononuclear Pt(III)–alkyl complex intermediate
in carbon–halogen bond coupling reactions. J Am Chem Soc 134:15261–15264
102. Kaspi AW, Goldberg I, Vigalok A (2010) Reagent-dependent formation of C−C and C−F
bonds in Pt complexes: An unexpected twist in the electrophilic fluorination chemistry. J Am
Chem Soc 132:10626–10627
103. Roy AH, Hartwig JF (2004) Reductive elimination of aryl halides upon addition of hindered alkylphosphines to dimeric arylpalladium(II) halide complexes. Organometallics
23:1533–1541
104. Canty AJ (1992) Development of organopalladium(IV) chemistry: fundamental aspects and
systems for studies of mechanism in organometallic chemistry and catalysis. Acc Chem Res
25:83–90
105. Rit RK, Yadav MR, Ghosh K, Shankar M, Sahoo AK (2014) Sulfoximine assisted Pd(II)catalyzed bromination and chlorination of primary β-C(sp
3
)–H bond. Org Lett 16:5258–5261
106. Yang X, Sun Y, Sun T, Rao Y (2016) Auxiliary-assisted palladium-catalyzed halogenation of
unactivated C(sp
3 )–H bonds at room temperature. Chem Commun 52:6423–6426
107. Xiong HY, Cahard D, Pannecoucke X, Besset T (2016) Pd‐catalyzed directed chlorination of
unactivated C(sp
3 )–H bonds at room temperature. Eur J Org Chem 3625–3630
108. Zhu Q, Ji D, Liang T, Wang X, Xu Y (2015) Efficient palladium-catalyzed C–H fluorination
of C(sp
3
)–H bonds: Synthesis of β-fluorinated carboxylic acids. Org Lett 17:3798–3801
109. Sun H, Zhang Y, Chen P, Wu YD, Zhang X, Huang Y (2016) Ligand‐assisted palladium(II)/
(IV) oxidation for sp
3
C–H Fluorination. Adv Synth Catal 358:1946–1957
110. Zhang Q, Yin XS, Chen K, Zhang SQ, Shi BF (2015) Stereoselective synthesis of chiral
β-fluoro α-amino acids via Pd(II)-catalyzed fluorination of unactivated methylene C(sp
3
)–H
bonds: Scope and mechanistic studies. J Am Chem Soc 137:8219–8226
111. Miao J, Yang K, Kurek M, Ge H (2015) Palladium-catalyzed site-selective fluorination of
unactivated C(sp
3 )–H bonds. Org Lett 17:3738–3741
112. Evans RW, Zbieg JR, Zhu S, Li W, MacMillan DWC (2013) Simple catalytic mechanism for
the direct coupling of α-carbonyls with functionalized amines: A one-step synthesis of plavix.
J Am Chem Soc 135:16074–16077
113. Tokumasu K, Yazaki R, Ohshima T (2016) Direct catalytic chemoselective α-amination
of acylpyrazoles: A concise route to unnatural α-amino acid derivatives. J Am Chem Soc
138:2664–2669
114. TMU T, Tejo C, DLY T, PWH C (2012) Copper(II) triflate catalyzed amination and aziridination of 2-alkyl substituted 1,3-dicarbonyl compounds. J Am Chem Soc 134:7344–7350
115. Zhao B, Du H, Shi Y (2008) A Cu(I)-catalyzed C−H α-amination of esters. Direct synthesis
of hydantoins. J Am Chem Soc 130:7220–7221
116. Ford RL, Alt I, Jana N, Driver TG (2019) Intramolecular Pd-catalyzed reductive amination of
enolizable sp
3 -C–H bonds. Org Lett 21:8827–8831
117. Zhi H, Ung SPM, Liu Y, Zhao L, Li CJ (2016) Phosphorylation of glycine derivatives via
copper(I)‐catalyzed Csp
3
−H bond functionalization. Adv Synth Catal 358:2553–2557
118. Huang LS, Han DY, Xu DZ (2019) Iron‐catalyzed cross‐dehydrogenative coupling of
oxindoles with thiols/selenols for direct C(sp
3 )−S/Se bond formation. Adv Synth Catal
361:4016–4021
A. Gupta et al.
98. Liu YJ, Liu YH, Zhang ZZ, Yan SY, Chen K, Shi BF (2016) Divergent and stereoselective
synthesis of β-silyl-α-amino acids through palladium-catalyzed intermolecular silylation of
unactivated primary and secondary C-H bonds. Angew Chem Int Ed 55:13859–13862
99. Pan JL, Li QZ, Zhang TY, Hou SH, Kang JC, Zhang SY (2016) Palladium-catalyzed
direct intermolecular silylation of remote unactivated C(sp
3
)–H bonds. Chem Commun
52:13151–13154
100. Deb A, Singh S, Seth K, Pimparkar S, Bhaskararao B, Guin S, Sunoj RB, Maiti D (2017)
Experimental and computational studies on remote γ-C(sp
3
)–H silylation and germanylation
of aliphatic carboxamides. ACS Catal 7:8171–8175
101. Wheelaghan OR, Ortuño MA, Díez J, Garrido SEG, Maya C, Lledos A, Conejero S
(2012) Characterization of a paramagnetic, mononuclear Pt(III)–alkyl complex intermediate
in carbon–halogen bond coupling reactions. J Am Chem Soc 134:15261–15264
102. Kaspi AW, Goldberg I, Vigalok A (2010) Reagent-dependent formation of C−C and C−F
bonds in Pt complexes: An unexpected twist in the electrophilic fluorination chemistry. J Am
Chem Soc 132:10626–10627
103. Roy AH, Hartwig JF (2004) Reductive elimination of aryl halides upon addition of hindered alkylphosphines to dimeric arylpalladium(II) halide complexes. Organometallics
23:1533–1541
104. Canty AJ (1992) Development of organopalladium(IV) chemistry: fundamental aspects and
systems for studies of mechanism in organometallic chemistry and catalysis. Acc Chem Res
25:83–90
105. Rit RK, Yadav MR, Ghosh K, Shankar M, Sahoo AK (2014) Sulfoximine assisted Pd(II)catalyzed bromination and chlorination of primary β-C(sp
3
)–H bond. Org Lett 16:5258–5261
106. Yang X, Sun Y, Sun T, Rao Y (2016) Auxiliary-assisted palladium-catalyzed halogenation of
unactivated C(sp
3 )–H bonds at room temperature. Chem Commun 52:6423–6426
107. Xiong HY, Cahard D, Pannecoucke X, Besset T (2016) Pd‐catalyzed directed chlorination of
unactivated C(sp
3 )–H bonds at room temperature. Eur J Org Chem 3625–3630
108. Zhu Q, Ji D, Liang T, Wang X, Xu Y (2015) Efficient palladium-catalyzed C–H fluorination
of C(sp
3
)–H bonds: Synthesis of β-fluorinated carboxylic acids. Org Lett 17:3798–3801
109. Sun H, Zhang Y, Chen P, Wu YD, Zhang X, Huang Y (2016) Ligand‐assisted palladium(II)/
(IV) oxidation for sp
3
C–H Fluorination. Adv Synth Catal 358:1946–1957
110. Zhang Q, Yin XS, Chen K, Zhang SQ, Shi BF (2015) Stereoselective synthesis of chiral
β-fluoro α-amino acids via Pd(II)-catalyzed fluorination of unactivated methylene C(sp
3
)–H
bonds: Scope and mechanistic studies. J Am Chem Soc 137:8219–8226
111. Miao J, Yang K, Kurek M, Ge H (2015) Palladium-catalyzed site-selective fluorination of
unactivated C(sp
3 )–H bonds. Org Lett 17:3738–3741
112. Evans RW, Zbieg JR, Zhu S, Li W, MacMillan DWC (2013) Simple catalytic mechanism for
the direct coupling of α-carbonyls with functionalized amines: A one-step synthesis of plavix.
J Am Chem Soc 135:16074–16077
113. Tokumasu K, Yazaki R, Ohshima T (2016) Direct catalytic chemoselective α-amination
of acylpyrazoles: A concise route to unnatural α-amino acid derivatives. J Am Chem Soc
138:2664–2669
114. TMU T, Tejo C, DLY T, PWH C (2012) Copper(II) triflate catalyzed amination and aziridination of 2-alkyl substituted 1,3-dicarbonyl compounds. J Am Chem Soc 134:7344–7350
115. Zhao B, Du H, Shi Y (2008) A Cu(I)-catalyzed C−H α-amination of esters. Direct synthesis
of hydantoins. J Am Chem Soc 130:7220–7221
116. Ford RL, Alt I, Jana N, Driver TG (2019) Intramolecular Pd-catalyzed reductive amination of
enolizable sp
3 -C–H bonds. Org Lett 21:8827–8831
117. Zhi H, Ung SPM, Liu Y, Zhao L, Li CJ (2016) Phosphorylation of glycine derivatives via
copper(I)‐catalyzed Csp
3
−H bond functionalization. Adv Synth Catal 358:2553–2557
118. Huang LS, Han DY, Xu DZ (2019) Iron‐catalyzed cross‐dehydrogenative coupling of
oxindoles with thiols/selenols for direct C(sp
3 )−S/Se bond formation. Adv Synth Catal
361:4016–4021
A. Gupta et al.