419
Scheme 65 Mechanistic
interpretation of the
α-methoxylation
the thiolation was achieved by employing an array of free arene thiols, the required
selenylation was realized upon using diphenyldiselenide. The requisite catalyst system is composed of CuI, DMSO, and a base, precisely K 3 PO 4 , to promote the chalcogenation process in a unique mechanism giving an expedient entry to practically
important variety of thio- and selenoethers. It is worth mentioning that during the
chalcogenation, DMSO plays crucial roles as a solvent as well as an oxidant to the
Scheme 66 α-Chalcogenation
of aliphatic carboxylic acids and
further derivatization