405
Ag 2 CO 3 , and PhCO 2 Na, operates in highly selective fashion to activate β-methyl
groups even in the presence of more reactive β-benzylic groups [94]. However, the
presence of γ-benzylic protons led to γ-lactams as the major product. However,
when an aromatic ring was present at the α-carbon, the ortho-protons of the ring
underwent activation under cobalt catalysis to provide indolin-2-one derivative as
the predominant product (Scheme 40).
The cobalt system also promotes the intermolecular amination reaction via the
C–N bond formation between 8-aminoquinoline-derived amides as the C–H substrate and α,α-disubstituted amides as the N source (Scheme 41) [94]. This
Scheme 38 Nickel-catalyzed β-lactam synthesis using TEMPO as a single-electron oxidant
Scheme 39 Proposed reaction pathway for the iodine-mediated C–H lactamization reaction
C(sp
3
)–H Bond Hetero-functionalization of Aliphatic Carboxylic Acid Equivalents…
Ag 2 CO 3 , and PhCO 2 Na, operates in highly selective fashion to activate β-methyl
groups even in the presence of more reactive β-benzylic groups [94]. However, the
presence of γ-benzylic protons led to γ-lactams as the major product. However,
when an aromatic ring was present at the α-carbon, the ortho-protons of the ring
underwent activation under cobalt catalysis to provide indolin-2-one derivative as
the predominant product (Scheme 40).
The cobalt system also promotes the intermolecular amination reaction via the
C–N bond formation between 8-aminoquinoline-derived amides as the C–H substrate and α,α-disubstituted amides as the N source (Scheme 41) [94]. This
Scheme 38 Nickel-catalyzed β-lactam synthesis using TEMPO as a single-electron oxidant
Scheme 39 Proposed reaction pathway for the iodine-mediated C–H lactamization reaction
C(sp
3
)–H Bond Hetero-functionalization of Aliphatic Carboxylic Acid Equivalents…