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position of the alkane residue giving practically useful synthetic yields. The coppercatalyzed reaction system follows the reactivity trend as β-benzylic > β- methyl > β
-ring > β-linear carbon centers. However, the substrate scope is slightly narrower
than the existing Pd-catalyzed intramolecular amidation protocol.
The copper-based catalytic cycle can also successfully operate to produce
β-lactams in the presence of oxygen as the terminal oxidant. This Cu-catalyzed
Scheme 31 Synthesis of β-lactam cores via sequential β-arylation/amination of carboxamides
Scheme 32 Palladium-catalyzed β-lactam synthesis and further derivatization
Scheme 33 Influence of C 6 F 5 I in controlling the C–N bond formations
A. Gupta et al.
position of the alkane residue giving practically useful synthetic yields. The coppercatalyzed reaction system follows the reactivity trend as β-benzylic > β- methyl > β
-ring > β-linear carbon centers. However, the substrate scope is slightly narrower
than the existing Pd-catalyzed intramolecular amidation protocol.
The copper-based catalytic cycle can also successfully operate to produce
β-lactams in the presence of oxygen as the terminal oxidant. This Cu-catalyzed
Scheme 31 Synthesis of β-lactam cores via sequential β-arylation/amination of carboxamides
Scheme 32 Palladium-catalyzed β-lactam synthesis and further derivatization
Scheme 33 Influence of C 6 F 5 I in controlling the C–N bond formations
A. Gupta et al.