107
39. van der Straat L, Vernooij M, Lammers M, van den Berg W, Schonewille T, Cordewener J,
van der Meer I, Koops A, de Graaff LH (2014) Expression of the Aspergillus terreus itaconic
acid biosynthesis cluster in Aspergillus Niger. Microb Cell Fact 13(1):11
40. Li A, van Luijk N, ter Beek M, Caspers M, Punt P, van der Werf M (2011) A clone-based
transcriptomics approach for the identification of genes relevant for itaconic acid production
in Aspergillus. Fungal Genet Biol 48(6):602–611
41. Kanamasa S, Dwiarti L, Okabe M, Park EY (2008) Cloning and functional characterization
of the cis-aconitic acid decarboxylase (CAD) gene from Aspergillus terreus. Appl Microbiol
Biotechnol 80(2):223–229
42. Li A, Pfelzer N, Zuijderwijk R, Brickwedde A, van Zeijl C, Punt P (2013) Reduced byproduct formation and modified oxygen availability improve itaconic acid production in
Aspergillus Niger. Appl Microbiol Biotechnol 97(9):3901–3911
43. Blumhoff ML, Steiger MG, Mattanovich D, Sauer M (2013a) Targeting enzymes to the
right compartment: metabolic engineering for itaconic acid production by Aspergillus Niger.
Metab Eng 19:26–32
44. Hossain AH, Li A, Brickwedde A, Wilms L, Caspers M, Overkamp K, Punt PJ (2016)
Rewiring a secondary metabolite pathway towards itaconic acid production in Aspergillus
Niger. Microb Cell Fact 15(1):130
45. Hossain AH, van Gerven R, Overkamp KM, Lübeck PS, Taşpınar H, Türker M, Punt PJ
(2019) Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation
improves itaconic acid production in Aspergillus Niger. Biotechnol Biofuels 12(1):233
46. Blumhoff M, Steiger MG, Marx H, Mattanovich D, Sauer M (2013b) Six novel constitutive promoters for metabolic engineering of Aspergillus Niger. Appl Microbiol Biotechnol
97(1):259–267
47. Yin X, Shin H-D, Li J, Du G, Liu L, Chen J (2017) Pgas, a low-pH-induced promoter, as a
tool for dynamic control of gene expression for metabolic engineering of Aspergillus Niger.
Appl Environ Microbiol 83(6):e03222–e03216
48. Pontrelli S, Chiu T-Y, Lan EI, Chen FYH, Chang P, Liao JC (2018) Escherichia coli as a host
for metabolic engineering. Metab Eng 50:16–46
49. Vuoristo KS, Mars AE, Sangra JV, Springer J, Eggink G, Sanders JPM, Weusthuis RA
(2015) Metabolic engineering of itaconate production in Escherichia coli. Appl Microbiol
Biotechnol 99(1):221–228
50. Okamoto S, Chin T, Hiratsuka K, Aso Y, Tanaka Y, Takahashi T, Ohara H (2014) Production
of itaconic acid using metabolically engineered Escherichia coli. J Gen Appl Microbiol
60(5):191–197
51. Tran K-NT, Somasundaram S, Eom GT, Hong SH (2019) Efficient Itaconic acid production
via protein–protein scaffold introduction between GltA, AcnA, and CadA in recombinant
Escherichia coli. Biotechnol Prog 35(3):e2799
52. Fatma Z, Hartman H, Poolman MG, Fell DA, Srivastava S, Shakeel T, Yazdani SS (2018)
Model-assisted metabolic engineering of Escherichia coli for long chain alkane and alcohol
production. Metab Eng 46:1–12
53. Harder B-J, Bettenbrock K, Klamt S (2016) Model-based metabolic engineering enables high
yield itaconic acid production by Escherichia coli. Metab Eng 38:29–37
54. Yang Z, Gao X, Xie H, Wang F, Ren Y, Wei D (2017) Enhanced itaconic acid production
by self-assembly of two biosynthetic enzymes in Escherichia coli. Biotechnol Bioeng
114(2):457–462
55. Yang Z, Wang H, Wang Y, Ren Y, Wei D (2018) Manufacturing multienzymatic complex
reactors in vivo by self-assembly to improve the biosynthesis of Itaconic acid in Escherichia
coli. ACS Synth Biol 7(5):1244–1250
56. Moon Y-M, Gurav R, Kim J, Hong Y-G, Bhatia SK, Jung H-R, Hong J-W, Choi TR, Yang SY,
Park HY, Joo H-S, Yang Y-H (2018) Whole-cell immobilization of engineered Escherichia
coli JY001 with barium-alginate for Itaconic acid production. Biotechnol Bioprocess Eng
23(4):442–447
Bio-Catalytic Itaconic Acid and Bio-Based Vinyl Monomer Production Processes
39. van der Straat L, Vernooij M, Lammers M, van den Berg W, Schonewille T, Cordewener J,
van der Meer I, Koops A, de Graaff LH (2014) Expression of the Aspergillus terreus itaconic
acid biosynthesis cluster in Aspergillus Niger. Microb Cell Fact 13(1):11
40. Li A, van Luijk N, ter Beek M, Caspers M, Punt P, van der Werf M (2011) A clone-based
transcriptomics approach for the identification of genes relevant for itaconic acid production
in Aspergillus. Fungal Genet Biol 48(6):602–611
41. Kanamasa S, Dwiarti L, Okabe M, Park EY (2008) Cloning and functional characterization
of the cis-aconitic acid decarboxylase (CAD) gene from Aspergillus terreus. Appl Microbiol
Biotechnol 80(2):223–229
42. Li A, Pfelzer N, Zuijderwijk R, Brickwedde A, van Zeijl C, Punt P (2013) Reduced byproduct formation and modified oxygen availability improve itaconic acid production in
Aspergillus Niger. Appl Microbiol Biotechnol 97(9):3901–3911
43. Blumhoff ML, Steiger MG, Mattanovich D, Sauer M (2013a) Targeting enzymes to the
right compartment: metabolic engineering for itaconic acid production by Aspergillus Niger.
Metab Eng 19:26–32
44. Hossain AH, Li A, Brickwedde A, Wilms L, Caspers M, Overkamp K, Punt PJ (2016)
Rewiring a secondary metabolite pathway towards itaconic acid production in Aspergillus
Niger. Microb Cell Fact 15(1):130
45. Hossain AH, van Gerven R, Overkamp KM, Lübeck PS, Taşpınar H, Türker M, Punt PJ
(2019) Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation
improves itaconic acid production in Aspergillus Niger. Biotechnol Biofuels 12(1):233
46. Blumhoff M, Steiger MG, Marx H, Mattanovich D, Sauer M (2013b) Six novel constitutive promoters for metabolic engineering of Aspergillus Niger. Appl Microbiol Biotechnol
97(1):259–267
47. Yin X, Shin H-D, Li J, Du G, Liu L, Chen J (2017) Pgas, a low-pH-induced promoter, as a
tool for dynamic control of gene expression for metabolic engineering of Aspergillus Niger.
Appl Environ Microbiol 83(6):e03222–e03216
48. Pontrelli S, Chiu T-Y, Lan EI, Chen FYH, Chang P, Liao JC (2018) Escherichia coli as a host
for metabolic engineering. Metab Eng 50:16–46
49. Vuoristo KS, Mars AE, Sangra JV, Springer J, Eggink G, Sanders JPM, Weusthuis RA
(2015) Metabolic engineering of itaconate production in Escherichia coli. Appl Microbiol
Biotechnol 99(1):221–228
50. Okamoto S, Chin T, Hiratsuka K, Aso Y, Tanaka Y, Takahashi T, Ohara H (2014) Production
of itaconic acid using metabolically engineered Escherichia coli. J Gen Appl Microbiol
60(5):191–197
51. Tran K-NT, Somasundaram S, Eom GT, Hong SH (2019) Efficient Itaconic acid production
via protein–protein scaffold introduction between GltA, AcnA, and CadA in recombinant
Escherichia coli. Biotechnol Prog 35(3):e2799
52. Fatma Z, Hartman H, Poolman MG, Fell DA, Srivastava S, Shakeel T, Yazdani SS (2018)
Model-assisted metabolic engineering of Escherichia coli for long chain alkane and alcohol
production. Metab Eng 46:1–12
53. Harder B-J, Bettenbrock K, Klamt S (2016) Model-based metabolic engineering enables high
yield itaconic acid production by Escherichia coli. Metab Eng 38:29–37
54. Yang Z, Gao X, Xie H, Wang F, Ren Y, Wei D (2017) Enhanced itaconic acid production
by self-assembly of two biosynthetic enzymes in Escherichia coli. Biotechnol Bioeng
114(2):457–462
55. Yang Z, Wang H, Wang Y, Ren Y, Wei D (2018) Manufacturing multienzymatic complex
reactors in vivo by self-assembly to improve the biosynthesis of Itaconic acid in Escherichia
coli. ACS Synth Biol 7(5):1244–1250
56. Moon Y-M, Gurav R, Kim J, Hong Y-G, Bhatia SK, Jung H-R, Hong J-W, Choi TR, Yang SY,
Park HY, Joo H-S, Yang Y-H (2018) Whole-cell immobilization of engineered Escherichia
coli JY001 with barium-alginate for Itaconic acid production. Biotechnol Bioprocess Eng
23(4):442–447
Bio-Catalytic Itaconic Acid and Bio-Based Vinyl Monomer Production Processes