145
Table 6.2 Effect of biologically synthesized nanoparticles on drug-resistant bacteria
Nanoparticle
Size and shape of
nanoparticle
Biological synthesis
process
Resistant bacteria
Observations
Reference(s)
Silver
Spherical, 5–30 nm
Extracellular
mycosynthesis using
culture filtrate of
Aspergillus flavus
Eight multidrug-resistant
isolates: E. coli, P. aeruginosa,
E. faecalis, S. aureus, M.
luteus, A. baumannii, K.
pneumoniae,
and Bacillus
spp.
Antibacterial activity of
imipenem, gentamicin,
vancomycin, and
ciprofloxacin augmented upon
being impregnated with silver
nanoparticles
Naqvi et al.
(2013)
Synergistic effect of antibiotics
and nanoparticles led to a
0.2–7.0-fold increase in
antibacterial activity
Silver
Spherical, 55–83 nm Synthesized using leaf
extract of Mimusops
elengi,
Linn.
Multidrug-resistant K.
pneumoniae, M. luteus,
and S.
aureus
Maximum antibacterial
activity against K.
pneumoniae
and moderate
activity against M. luteus, S.
aureus
Prakash et al.
(2013)
Silver
Spherical, 2–15 nm
Synthesized using
exopolysaccharide
extracted from L.
rhamnosus
GG
Multidrug-resistant P.
aeruginosa
and K.
pneumoniae
Dose-dependent inhibition of
bacteria
Kanmani and
Lim (2013)
Both bacteria were more
susceptible to nanoparticles
than L. monocytogenes
Dose-dependent biofilm
inhibition
100% inhibition of biofilm
formation by P. aeruginosa
at
56 μg/ml nanoparticle
concentration
(continued)
6 Exploring Microbial Nanotoxicity Against Drug Resistance in Bacteria