143
Table 6.1 (continued)
Nanoparticle
Nanoparticle
shape and size Resistant bacteria Observation
Reference(s)
Superparamagnetic
iron oxide
nanoparticles
(SPION)
9.92 ± 3.14 nm Methicillinresistant S. aureus
(Mu50 strain)
Decreased
planktonic
growth and viable
bacteria counts
Durmus et al.
(2013)
81% increase in
antibiofilm
efficacy in the
presence of
fructose
metabolite
Eradicated
methicillinresistant S. aureus
biofilms better
than vancomycin
Silver
Spherical,
5–12 nm
Carbapenemresistant A.
baumannii
Growth of A.
baumannii
completely
inhibited at
2.5 μg/mL
Wan et al.
(2016)
Nanoparticle
showed
synergistic effects
with polymyxin B
and rifampicin;
additive effect
with tigecycline
Silver
Spherical,
11 nm
Multidrugresistant S. aureus
and P. aeruginosa
Time- and
dose-dependent
antibacterial
effects of
nanoparticles
Yuan et al.
(2017)
Magnesium oxide
Spherical, size
<100 nm
E. coli, K.
pneumoniae and
S. aureus
Accelerated rate
of membrane
disruption in the
presence of
nanoparticles
Hayat et al.
(2018)
Time-dependent
reduction in
biofilm
formation
potential
Significant
reduction in
biomass of
48–120 hr old
biofilms
(continued)
6 Exploring Microbial Nanotoxicity Against Drug Resistance in Bacteria