2 Hydrogenation of Nitriles
2.1 Hydrogenation of Nitriles to Amines
A range of different pincer complexes based on ruthenium, iron, cobalt and
manganese have been used for the hydrogenation of nitriles to the primary amines
(Scheme 2).
N
P
P i Pr 2
Mn
CO
CO
Br
H
6a Beller, 2016
Co
Cl
N
N
N
N
Py
Cl
Mes
Mes
10 Fout, 2017
N
P
NH t Bu
Co
Cl Cl
7 Milstein, 2015
N
P
P i Pr 2
Fe
CO
H
HBH 3
H
5a Beller, 2014
N
P
Cy2
P Cy2
Fe
CO
H
HBH 3
H
N
P t Bu 2
Ru
HBH 3
H
CO
H
N
N
3 Beller, 2016
N
P
R 2
PR 2
Co
X
X
H
N Co X
X
H
N
N
Beller, 2019
N
P
P t Bu 2
Ru
H
H
1 Leitner, 2011
H H
4 Milstein, 2017
2 Beller, 2015
N
P
Ph 2
PPh 2
Ru
CO
H
HBH 3
H
N
P t Bu 2
Co
Cl
Cl
H
N
N
N
P t Bu 2
Co
Cl
Cl
H
N
Liu, 2016
12 X=Br/Cl
5b Beller, 2016
N
P
Et 2
PEt 2
Fe
CO
H
HBH 3
H
5c Beller, 2016
11 R =
i Pr/Cy/Ph
N
t Bu 2 P
P t Bu 2
Ru
H CO
R C N
cat
R
NH 2
8
9
H 2
i Pr 2
t Bu 2
t Bu 2
i Pr 2
Scheme 2 Pincer complexes used as catalyst for the hydrogenation of nitriles to amines
324
B. Guo et al.