138
6 Risk Assessment and Management of Chemical Products
Fig. 6.17 A simplified overview of some of the toxicity testing requirements in the EU for
industrial chemicals registered under REACH, depending on annual production volume (metric
tons). Testing requirements in each volume step are in addition to the requirements in the step(s)
below it. See REACH Annexes VII–X for full testing requirements (European Union, 2006)
of the dose-response relationship facilitates extrapolation from the quantified effect
on the selected test organism to a maximum concentration deemed fit to protect
humans or entire environmental ecosystems.
Fig. 6.18 Formats for statistical representation of a dose-response relationship: frequency distribution, cumulative distribution, and linearized cumulative distribution
6 Risk Assessment and Management of Chemical Products
Fig. 6.17 A simplified overview of some of the toxicity testing requirements in the EU for
industrial chemicals registered under REACH, depending on annual production volume (metric
tons). Testing requirements in each volume step are in addition to the requirements in the step(s)
below it. See REACH Annexes VII–X for full testing requirements (European Union, 2006)
of the dose-response relationship facilitates extrapolation from the quantified effect
on the selected test organism to a maximum concentration deemed fit to protect
humans or entire environmental ecosystems.
Fig. 6.18 Formats for statistical representation of a dose-response relationship: frequency distribution, cumulative distribution, and linearized cumulative distribution