4 FLP-Mediated C–H-Activation
155
Fig. 4.14 Thermodynamic and kinetic considerations for the transfer borylation reaction
N
F
F
F
NHMe 2
nBu
H-H
N
F
F
F
NMe 2
nBu
BCat
[B(C 6 F 5 ) 4 ]
-
[B(C 6 F 5 ) 4 ]
-
E
26 (2.5 mol%)
E
BCat
80 °C, 10 h
DCE
N
Me
S
Me
BCat
86%
74 %
2-BCat : 5-BCat (86:14)
Int52
HBCat
HBCat
+
+
H H
BCat
26
Me
N
Me
N
BCat
Scheme 4.48 Borylation of indoles using aminopyridine catalyst
155
Fig. 4.14 Thermodynamic and kinetic considerations for the transfer borylation reaction
N
F
F
F
NHMe 2
nBu
H-H
N
F
F
F
NMe 2
nBu
BCat
[B(C 6 F 5 ) 4 ]
-
[B(C 6 F 5 ) 4 ]
-
E
26 (2.5 mol%)
E
BCat
80 °C, 10 h
DCE
N
Me
S
Me
BCat
86%
74 %
2-BCat : 5-BCat (86:14)
Int52
HBCat
HBCat
+
+
H H
BCat
26
Me
N
Me
N
BCat
Scheme 4.48 Borylation of indoles using aminopyridine catalyst