36. Marco-Dufort B, Tibbitt MW (2019) Design of moldable hydrogels for biomedical applications
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37. Kitano S, Kataoka K, Koyama Y, Okano T, Sakurai Y (1991) Glucose-responsive complex
formation between poly(vinyl alcohol) and poly(N-vinyl-2-pyrrolidone) with pendent
phenylboronic acid moieties. Makromol Chem Rapid 12:227–233. https://doi.org/10.1002/
marc.1991.030120405
38. He L, Fullenkamp DE, Rivera JG, Messersmith PB (2011) pH responsive self-healing
hydrogels formed by boronate-catechol complexation. Chem Commun 47:7497–7499. https://
doi.org/10.1039/c1cc11928a
39. Roberts BMC, Hanson MC, Massey AP, Karren EA, Kiser PF (2007) Dynamically
restructuring hydrogel networks formed with reversible covalent crosslinks. Adv Mater
19:2503–2507. https://doi.org/10.1002/adma.200602649
40. Deng CC, Brooks WLA, Abboud KA, Sumerlin BS (2015) Boronic acid-based hydrogels
undergo self-healing at neutral and acidic pH. ACS Macro Lett 4:220–224. https://doi.org/10.
1021/acsmacrolett.5b00018
41. Yesilyurt V, Webber MJ, Appel EA, Godwin C, Langer R, Anderson DG (2016) Injectable selfhealing glucose-responsive hydrogels with pH-regulated mechanical properties. Adv Mater
28:86–91. https://doi.org/10.1002/adma.201502902
42. Shan M, Gong C, Li B, Wu G (2017) A pH, glucose, and dopamine triple-responsive, selfhealable adhesive hydrogel formed by phenylborate-catechol complexation. Polym Chem
8:2997–3005. https://doi.org/10.1039/c7py00519a
43. Tseng TC, Hsieh FY, Theato P, Wei Y, Hsu SH (2017) Glucose-sensitive self-healing hydrogel
as sacrificial materials to fabricate vascularized constructs. Biomaterials 133:20–28. https://doi.
org/10.1016/j.biomaterials.2017.04.008
44. Chen W, Hao D, Hao W, Guo X, Jiang L (2018) Hydrogel with ultrafast self-healing property
both in air and underwater. ACS Appl Mater Interfaces 10:1258–1265. https://doi.org/10.1021/
acsami.7b17118
45. Amaral AJR, Emamzadeh M, Pasparakis G (2018) Transiently malleable multi-healable hydrogel nanocomposites based on responsive boronic acid copolymers. Polym Chem 9:525–537.
https://doi.org/10.1039/c7py01202k
46. Wang M, Chen Y, Khan R, Liu H, Chen C, Chen T, Zhang R, Li H (2019) A fast self-healing
and conductive nanocomposite hydrogel as soft strain sensor. Colloids Surf A Physicochem
Eng Asp 567:139–149. https://doi.org/10.1016/j.colsurfa.2019.01.034
47. Kotsuchibashi Y, Agustin RVC, Lu J-Y, Hall DG, Narain R (2013) Temperature, pH, and
glucose responsive gels via simple mixing of boroxole- and glyco-based polymers. ACS Macro
Lett 2:260–264. https://doi.org/10.1021/mz400076p
48. Chen Y, Wang W, Wu D, Nagao M, Hall DG, Thundat T, Narain R (2018) Injectable selfhealing zwitterionic hydrogels based on dynamic benzoxaborole-sugar interactions with tunable
mechanical properties. Biomacromolecules 19:596–605. https://doi.org/10.1021/acs.biomac.
7b01679
49. Wang Y, Li L, Kotsuchibashi Y, Vshyvenko S, Liu Y, Hall D, Zeng H, Narain R (2016) Selfhealing and injectable shear thinning hydrogels based on dynamic oxaborole-diol covalent
cross-linking. ACS Biomater Sci Eng 2:2315–2323. https://doi.org/10.1021/acsbiomaterials.
6b00527
50. Chen Y, Tan Z, Wang W, Peng Y, Narain R (2019) Injectable, self-healing, and multiresponsive hydrogels via dynamic covalent bond formation between benzoxaborole and
hydroxyl groups. Biomacromolecules 20:1028–1035. https://doi.org/10.1021/acs.biomac.
8b01652
51. Wu D, Wang W, Diaz-Dussan D, Peng Y, Chen Y, Narain R, Hall DG (2019) In situ forming,
dual-crosslink network, self-healing hydrogel enabled by a bioorthogonal nopoldiolbenzoxaborolate click reaction with a wide pH range. Chem Mater 31:4092–4102. https://doi.
org/10.1021/acs.chemmater.9b00769
292
R. Kilic and A. Sanyal
using dynamic covalent boronic esters. Mater Today Chem 12:16–33. https://doi.org/10.1016/J.
MTCHEM.2018.12.001
37. Kitano S, Kataoka K, Koyama Y, Okano T, Sakurai Y (1991) Glucose-responsive complex
formation between poly(vinyl alcohol) and poly(N-vinyl-2-pyrrolidone) with pendent
phenylboronic acid moieties. Makromol Chem Rapid 12:227–233. https://doi.org/10.1002/
marc.1991.030120405
38. He L, Fullenkamp DE, Rivera JG, Messersmith PB (2011) pH responsive self-healing
hydrogels formed by boronate-catechol complexation. Chem Commun 47:7497–7499. https://
doi.org/10.1039/c1cc11928a
39. Roberts BMC, Hanson MC, Massey AP, Karren EA, Kiser PF (2007) Dynamically
restructuring hydrogel networks formed with reversible covalent crosslinks. Adv Mater
19:2503–2507. https://doi.org/10.1002/adma.200602649
40. Deng CC, Brooks WLA, Abboud KA, Sumerlin BS (2015) Boronic acid-based hydrogels
undergo self-healing at neutral and acidic pH. ACS Macro Lett 4:220–224. https://doi.org/10.
1021/acsmacrolett.5b00018
41. Yesilyurt V, Webber MJ, Appel EA, Godwin C, Langer R, Anderson DG (2016) Injectable selfhealing glucose-responsive hydrogels with pH-regulated mechanical properties. Adv Mater
28:86–91. https://doi.org/10.1002/adma.201502902
42. Shan M, Gong C, Li B, Wu G (2017) A pH, glucose, and dopamine triple-responsive, selfhealable adhesive hydrogel formed by phenylborate-catechol complexation. Polym Chem
8:2997–3005. https://doi.org/10.1039/c7py00519a
43. Tseng TC, Hsieh FY, Theato P, Wei Y, Hsu SH (2017) Glucose-sensitive self-healing hydrogel
as sacrificial materials to fabricate vascularized constructs. Biomaterials 133:20–28. https://doi.
org/10.1016/j.biomaterials.2017.04.008
44. Chen W, Hao D, Hao W, Guo X, Jiang L (2018) Hydrogel with ultrafast self-healing property
both in air and underwater. ACS Appl Mater Interfaces 10:1258–1265. https://doi.org/10.1021/
acsami.7b17118
45. Amaral AJR, Emamzadeh M, Pasparakis G (2018) Transiently malleable multi-healable hydrogel nanocomposites based on responsive boronic acid copolymers. Polym Chem 9:525–537.
https://doi.org/10.1039/c7py01202k
46. Wang M, Chen Y, Khan R, Liu H, Chen C, Chen T, Zhang R, Li H (2019) A fast self-healing
and conductive nanocomposite hydrogel as soft strain sensor. Colloids Surf A Physicochem
Eng Asp 567:139–149. https://doi.org/10.1016/j.colsurfa.2019.01.034
47. Kotsuchibashi Y, Agustin RVC, Lu J-Y, Hall DG, Narain R (2013) Temperature, pH, and
glucose responsive gels via simple mixing of boroxole- and glyco-based polymers. ACS Macro
Lett 2:260–264. https://doi.org/10.1021/mz400076p
48. Chen Y, Wang W, Wu D, Nagao M, Hall DG, Thundat T, Narain R (2018) Injectable selfhealing zwitterionic hydrogels based on dynamic benzoxaborole-sugar interactions with tunable
mechanical properties. Biomacromolecules 19:596–605. https://doi.org/10.1021/acs.biomac.
7b01679
49. Wang Y, Li L, Kotsuchibashi Y, Vshyvenko S, Liu Y, Hall D, Zeng H, Narain R (2016) Selfhealing and injectable shear thinning hydrogels based on dynamic oxaborole-diol covalent
cross-linking. ACS Biomater Sci Eng 2:2315–2323. https://doi.org/10.1021/acsbiomaterials.
6b00527
50. Chen Y, Tan Z, Wang W, Peng Y, Narain R (2019) Injectable, self-healing, and multiresponsive hydrogels via dynamic covalent bond formation between benzoxaborole and
hydroxyl groups. Biomacromolecules 20:1028–1035. https://doi.org/10.1021/acs.biomac.
8b01652
51. Wu D, Wang W, Diaz-Dussan D, Peng Y, Chen Y, Narain R, Hall DG (2019) In situ forming,
dual-crosslink network, self-healing hydrogel enabled by a bioorthogonal nopoldiolbenzoxaborolate click reaction with a wide pH range. Chem Mater 31:4092–4102. https://doi.
org/10.1021/acs.chemmater.9b00769
292
R. Kilic and A. Sanyal