52. Tarus D, Hachet E, Messager L, Catargi B, Ravaine V, Auzély-Velty R (2014) Readily prepared
dynamic hydrogels by combining phenyl boronic acid- and maltose-modified anionic polysaccharides at neutral pH. Macromol Rapid Commun 35:2089–2095. https://doi.org/10.1002/
marc.201400477
53. Li N, Liu C, Chen W (2019) Facile access to guar gum based supramolecular hydrogels with
rapid self-healing ability and multistimuli responsive gel-sol transitions. J Agric Food Chem
67:746–752. https://doi.org/10.1021/acs.jafc.8b05130
54. Liu YL, Chuo TW (2013) Self-healing polymers based on thermally reversible Diels-Alder
chemistry. Polym Chem 4:2194–2205. https://doi.org/10.1039/C2PY20957H
55. Chen X, Dam XC, Ono K, Mal A, Shen H, Nutt SR, Sheran K, Wudl F (2002) A thermally
re-mendable cross-linked polymeric material. Science 295:1698–1702. https://doi.org/10.1126/
science.1065879
56. Kavitha AA, Singha NK (2009) “Click chemistry” in tailor-made polymethacrylates bearing
reactive furfuryl functionality: a new class of self-healing polymeric material. ACS Appl Mater
Interfaces 1:1427–1436. https://doi.org/10.1021/am900124c
57. Wei Z, Yang JH, Du XJ, Xu F, Zrinyi M, Osada Y, Li F, Chen YM (2013) Dextran-based selfhealing hydrogels formed by reversible Diels-Alder reaction under physiological conditions.
Macromol Rapid Commun 34:1464–1470. https://doi.org/10.1002/marc.201300494
58. Yoon JA, Kamada J, Koynov K, Mohin J, Nicola R, Zhang Y, Balazs AC, Kowalewski T,
Matyjaszewski K (2012) Self-healing polymer films based on thiol-disulfide exchange reactions
and self-healing kinetics measured using atomic force microscopy. Macromolecules
45:142–149. https://doi.org/10.1021/ma2015134
59. Barcan GA, Zhang X, Waymouth RM (2015) Structurally dynamic hydrogels derived from
1,2-dithiolanes. J Am Chem Soc 137:5650–5653. https://doi.org/10.1021/jacs.5b02161
60. Yu H, Wang Y, Yang H, Peng K, Zhang X (2017) Injectable self-healing hydrogels formed via
thiol/disulfide exchange of thiol functionalized F127 and dithiolane modified PEG. J Mater
Chem B 5:4121–4127. https://doi.org/10.1039/C7TB00746A
61. Zhang X, Waymouth RM (2017) 1,2-Dithiolane-derived dynamic, covalent materials: cooperative self-assembly and reversible cross-linking. J Am Chem Soc 139:3822–3833. https://doi.
org/10.1021/jacs.7b00039
62. Chung CM, Roh YS, Cho SY, Kim JG (2004) Crack healing in polymeric materials via
photochemical [2+2] cycloaddition. Chem Mater 16(21):3982–3984. https://doi.org/10.1021/
cm049394+
63. Banerjee S, Tripathy R, Cozzens D, Nagy T, Keki S, Zsuga M, Faust R (2015) Photoinduced
smart, self-healing polymer sealant for photovoltaics. ACS Appl Mater Interfaces 7:2064–2072.
https://doi.org/10.1021/am508096c
64. Yang K, Zeng M (2013) Multiresponsive hydrogel based on polyacrylamide functionalized
with thymine derivatives. New J Chem 37:920–926. https://doi.org/10.1039/c3nj41013g
65. Van-Pham DT, Nguyen MT, Ohdomari K, Nakanishi H, Norisuye T, Tran-Cong-Miyata Q
(2017) Controlling the nano-deformation of polymer by a reversible photo-cross-linking reaction. Adv Nat Sci Nanosci Nanotechnol 8:025003. https://doi.org/10.1088/2043-6254/aa690d
66. Zhang H, Zeng D, Pan Y, Chen Y, Ruan Y, Xu Y, Boulatov R, Creton C, Weng W (2019)
Mechanochromism and optical remodeling of multi-network elastomers containing anthracene
dimers. Chem Sci 10:8367–8373. https://doi.org/10.1039/c9sc02580d
67. Truong VX, Li F, Ercole F, Forsythe JS (2018) Wavelength-selective coupling and decoupling
of polymer chains via reversible [2+2] photocycloaddition of styrylpyrene for construction of
cytocompatible photodynamic hydrogels. ACS Macro Lett 7:464–469. https://doi.org/10.1021/
acsmacrolett.8b00099
68. Ahn D, Zavada SR, Scott TF (2017) Rapid, photomediated healing of hexaarylbiimidazolebased covalently cross-linked gels. Chem Mater 29:7023–7031. https://doi.org/10.1021/acs.
chemmater.7b02640
69. Xiang SL, Hua QX, Gong WL, Xie NH, Zhao PJ, Cheng GJ, Li C, Zhu MQ (2019) Photoplastic
transformation based on dynamic covalent chemistry. ACS Appl Mater Interfaces
11:23623–23631. https://doi.org/10.1021/acsami.9b06608
Self-Healing Hydrogels Based on Reversible Covalent Linkages: A Survey of. . .
293
dynamic hydrogels by combining phenyl boronic acid- and maltose-modified anionic polysaccharides at neutral pH. Macromol Rapid Commun 35:2089–2095. https://doi.org/10.1002/
marc.201400477
53. Li N, Liu C, Chen W (2019) Facile access to guar gum based supramolecular hydrogels with
rapid self-healing ability and multistimuli responsive gel-sol transitions. J Agric Food Chem
67:746–752. https://doi.org/10.1021/acs.jafc.8b05130
54. Liu YL, Chuo TW (2013) Self-healing polymers based on thermally reversible Diels-Alder
chemistry. Polym Chem 4:2194–2205. https://doi.org/10.1039/C2PY20957H
55. Chen X, Dam XC, Ono K, Mal A, Shen H, Nutt SR, Sheran K, Wudl F (2002) A thermally
re-mendable cross-linked polymeric material. Science 295:1698–1702. https://doi.org/10.1126/
science.1065879
56. Kavitha AA, Singha NK (2009) “Click chemistry” in tailor-made polymethacrylates bearing
reactive furfuryl functionality: a new class of self-healing polymeric material. ACS Appl Mater
Interfaces 1:1427–1436. https://doi.org/10.1021/am900124c
57. Wei Z, Yang JH, Du XJ, Xu F, Zrinyi M, Osada Y, Li F, Chen YM (2013) Dextran-based selfhealing hydrogels formed by reversible Diels-Alder reaction under physiological conditions.
Macromol Rapid Commun 34:1464–1470. https://doi.org/10.1002/marc.201300494
58. Yoon JA, Kamada J, Koynov K, Mohin J, Nicola R, Zhang Y, Balazs AC, Kowalewski T,
Matyjaszewski K (2012) Self-healing polymer films based on thiol-disulfide exchange reactions
and self-healing kinetics measured using atomic force microscopy. Macromolecules
45:142–149. https://doi.org/10.1021/ma2015134
59. Barcan GA, Zhang X, Waymouth RM (2015) Structurally dynamic hydrogels derived from
1,2-dithiolanes. J Am Chem Soc 137:5650–5653. https://doi.org/10.1021/jacs.5b02161
60. Yu H, Wang Y, Yang H, Peng K, Zhang X (2017) Injectable self-healing hydrogels formed via
thiol/disulfide exchange of thiol functionalized F127 and dithiolane modified PEG. J Mater
Chem B 5:4121–4127. https://doi.org/10.1039/C7TB00746A
61. Zhang X, Waymouth RM (2017) 1,2-Dithiolane-derived dynamic, covalent materials: cooperative self-assembly and reversible cross-linking. J Am Chem Soc 139:3822–3833. https://doi.
org/10.1021/jacs.7b00039
62. Chung CM, Roh YS, Cho SY, Kim JG (2004) Crack healing in polymeric materials via
photochemical [2+2] cycloaddition. Chem Mater 16(21):3982–3984. https://doi.org/10.1021/
cm049394+
63. Banerjee S, Tripathy R, Cozzens D, Nagy T, Keki S, Zsuga M, Faust R (2015) Photoinduced
smart, self-healing polymer sealant for photovoltaics. ACS Appl Mater Interfaces 7:2064–2072.
https://doi.org/10.1021/am508096c
64. Yang K, Zeng M (2013) Multiresponsive hydrogel based on polyacrylamide functionalized
with thymine derivatives. New J Chem 37:920–926. https://doi.org/10.1039/c3nj41013g
65. Van-Pham DT, Nguyen MT, Ohdomari K, Nakanishi H, Norisuye T, Tran-Cong-Miyata Q
(2017) Controlling the nano-deformation of polymer by a reversible photo-cross-linking reaction. Adv Nat Sci Nanosci Nanotechnol 8:025003. https://doi.org/10.1088/2043-6254/aa690d
66. Zhang H, Zeng D, Pan Y, Chen Y, Ruan Y, Xu Y, Boulatov R, Creton C, Weng W (2019)
Mechanochromism and optical remodeling of multi-network elastomers containing anthracene
dimers. Chem Sci 10:8367–8373. https://doi.org/10.1039/c9sc02580d
67. Truong VX, Li F, Ercole F, Forsythe JS (2018) Wavelength-selective coupling and decoupling
of polymer chains via reversible [2+2] photocycloaddition of styrylpyrene for construction of
cytocompatible photodynamic hydrogels. ACS Macro Lett 7:464–469. https://doi.org/10.1021/
acsmacrolett.8b00099
68. Ahn D, Zavada SR, Scott TF (2017) Rapid, photomediated healing of hexaarylbiimidazolebased covalently cross-linked gels. Chem Mater 29:7023–7031. https://doi.org/10.1021/acs.
chemmater.7b02640
69. Xiang SL, Hua QX, Gong WL, Xie NH, Zhao PJ, Cheng GJ, Li C, Zhu MQ (2019) Photoplastic
transformation based on dynamic covalent chemistry. ACS Appl Mater Interfaces
11:23623–23631. https://doi.org/10.1021/acsami.9b06608
Self-Healing Hydrogels Based on Reversible Covalent Linkages: A Survey of. . .
293