linkage between micelles and polymer chains based on different mechanisms,
including supramolecular recognition and dynamic bonding, has been demonstrated
to tune the stretchability, injectability, self-healing, and stimulus-responsiveness.
These merits and properties are promising for applications as soft actuators and
biomedical engineering.
Acknowledgment This work is supported by the National Natural Science Foundation of China
(51873224 and 21574145) and MOE Key Laboratory of Macromolecular Synthesis and
Functionalization, Zhejiang University (2018MSF04).
References
1. Fu J, in het Panhuis M (2019) Hydrogel properties and applications. J Mater Chem B
7(10):1523–1525. https://doi.org/10.1039/C9TB90023C
2. Zhao X (2014) Multi-scale multi-mechanism design of tough hydrogels: building dissipation
into stretchy networks. Soft Matter 10(5):672–687. https://doi.org/10.1039/c3sm52272e
3. Fu J (2018) Strong and tough hydrogels crosslinked by multi-functional polymer colloids.
J Polym Sci B Polym Phys 56(19):1336–1350. https://doi.org/10.1002/polb.24728
4. Tuncaboylu DC, Sari M, Oppermann W, Okay O (2011) Tough and self-healing hydrogels
formed via hydrophobic interactions. Macromolecules 44(12):4997–5005. https://doi.org/10.
1021/ma200579v
5. Can V, Kochovski Z, Reiter V, Severin N, Siebenbürger M, Kent B, Just J, Rabe JP, Ballauff M,
Okay O (2016) Nanostructural evolution and self-healing mechanism of micellar hydrogels.
Macromolecules 49(6):2281–2287. https://doi.org/10.1021/acs.macromol.6b00156
6. Bilici C, Can V, Nöchel U, Behl M, Lendlein A, Okay O (2016) Melt-processable shapememory hydrogels with self-healing ability of high mechanical strength. Macromolecules
49(19):7442–7449. https://doi.org/10.1021/acs.macromol.6b01539
7. He C, Jiao K, Zhang X, Xiang M, Li Z, Wang H (2011) Nanoparticles, microgels and bulk
hydrogels with very high mechanical strength starting from micelles. Soft Matter 7:2943–2952
8. He C, Zheng Z, Zhao D, Liu J, Ouyang J, Wang H (2013) Tough and super-resilient hydrogels
synthesized by using peroxidized polymer chains as polyfunctional initiating and cross-linking
centers. Soft Matter 9(10):2837–2844. https://doi.org/10.1039/C2SM27605D
9. Fu J, Luan B, Yu X, Cong Y, Li J, Pan C, Han Y, Yang Y, Li B (2004) Self-assembly of
crystallineÀcoil diblock copolymer in solvents with varying selectivity: from spinodal-like
aggregates to spheres, cylinders, and lamellae. Macromolecules 37(3):976–986. https://doi.org/
10.1021/ma035447h
10. Wanka G, Hoffmann H, Ulbricht W (1994) Phase diagrams and aggregation behavior of poly
(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) triblock copolymers in aqueous solutions. Macromolecules 27(15):4145–4159. https://doi.org/10.1021/ma00093a016
11. Riess G (2003) Micellization of block copolymers. Prog Polym Sci 28(7):1107–1170. https://
doi.org/10.1016/S0079-6700(03)00015-7
12. Bahadur P, Pandya K (1992) Aggregation behavior of Pluronic P-94 in water. Langmuir
8(11):2666–2670. https://doi.org/10.1021/la00047a016
13. Lee S-Y, Tae G (2007) Formulation and in vitro characterization of an in situ gelable, photopolymerizable Pluronic hydrogel suitable for injection. J Control Release 119(3):313–319.
https://doi.org/10.1016/j.jconrel.2007.03.007
14. Gou M, Li X, Dai M, Gong C, Wang X, Xie Y, Deng H, Chen L, Zhao X, Qian Z, Wei Y (2008)
A novel injectable local hydrophobic drug delivery system: biodegradable nanoparticles in
238
J. Fu
including supramolecular recognition and dynamic bonding, has been demonstrated
to tune the stretchability, injectability, self-healing, and stimulus-responsiveness.
These merits and properties are promising for applications as soft actuators and
biomedical engineering.
Acknowledgment This work is supported by the National Natural Science Foundation of China
(51873224 and 21574145) and MOE Key Laboratory of Macromolecular Synthesis and
Functionalization, Zhejiang University (2018MSF04).
References
1. Fu J, in het Panhuis M (2019) Hydrogel properties and applications. J Mater Chem B
7(10):1523–1525. https://doi.org/10.1039/C9TB90023C
2. Zhao X (2014) Multi-scale multi-mechanism design of tough hydrogels: building dissipation
into stretchy networks. Soft Matter 10(5):672–687. https://doi.org/10.1039/c3sm52272e
3. Fu J (2018) Strong and tough hydrogels crosslinked by multi-functional polymer colloids.
J Polym Sci B Polym Phys 56(19):1336–1350. https://doi.org/10.1002/polb.24728
4. Tuncaboylu DC, Sari M, Oppermann W, Okay O (2011) Tough and self-healing hydrogels
formed via hydrophobic interactions. Macromolecules 44(12):4997–5005. https://doi.org/10.
1021/ma200579v
5. Can V, Kochovski Z, Reiter V, Severin N, Siebenbürger M, Kent B, Just J, Rabe JP, Ballauff M,
Okay O (2016) Nanostructural evolution and self-healing mechanism of micellar hydrogels.
Macromolecules 49(6):2281–2287. https://doi.org/10.1021/acs.macromol.6b00156
6. Bilici C, Can V, Nöchel U, Behl M, Lendlein A, Okay O (2016) Melt-processable shapememory hydrogels with self-healing ability of high mechanical strength. Macromolecules
49(19):7442–7449. https://doi.org/10.1021/acs.macromol.6b01539
7. He C, Jiao K, Zhang X, Xiang M, Li Z, Wang H (2011) Nanoparticles, microgels and bulk
hydrogels with very high mechanical strength starting from micelles. Soft Matter 7:2943–2952
8. He C, Zheng Z, Zhao D, Liu J, Ouyang J, Wang H (2013) Tough and super-resilient hydrogels
synthesized by using peroxidized polymer chains as polyfunctional initiating and cross-linking
centers. Soft Matter 9(10):2837–2844. https://doi.org/10.1039/C2SM27605D
9. Fu J, Luan B, Yu X, Cong Y, Li J, Pan C, Han Y, Yang Y, Li B (2004) Self-assembly of
crystallineÀcoil diblock copolymer in solvents with varying selectivity: from spinodal-like
aggregates to spheres, cylinders, and lamellae. Macromolecules 37(3):976–986. https://doi.org/
10.1021/ma035447h
10. Wanka G, Hoffmann H, Ulbricht W (1994) Phase diagrams and aggregation behavior of poly
(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) triblock copolymers in aqueous solutions. Macromolecules 27(15):4145–4159. https://doi.org/10.1021/ma00093a016
11. Riess G (2003) Micellization of block copolymers. Prog Polym Sci 28(7):1107–1170. https://
doi.org/10.1016/S0079-6700(03)00015-7
12. Bahadur P, Pandya K (1992) Aggregation behavior of Pluronic P-94 in water. Langmuir
8(11):2666–2670. https://doi.org/10.1021/la00047a016
13. Lee S-Y, Tae G (2007) Formulation and in vitro characterization of an in situ gelable, photopolymerizable Pluronic hydrogel suitable for injection. J Control Release 119(3):313–319.
https://doi.org/10.1016/j.jconrel.2007.03.007
14. Gou M, Li X, Dai M, Gong C, Wang X, Xie Y, Deng H, Chen L, Zhao X, Qian Z, Wei Y (2008)
A novel injectable local hydrophobic drug delivery system: biodegradable nanoparticles in
238
J. Fu