9 Pharmaceutical Multicomponent Crystals: Structure, Design …
171
Fig. 9.15 Photoisomerization of EPR accounting for its photoinstability. Reprinted (adapted or
reprinted in part) with permission from [79]. Copyright 2011 American Chemical Society
cases. Therefore, further attempts to obtain pure cocrystals were only conducted
using the above two techniques and a 2:1 EPR/BET molar ratio. As illustrated in
Fig. 9.16, no raw material peaks were observed under these conditions, indicating
the formation of a new phase. In addition, the new PXRD patterns matched well with
the simulated ones, suggesting high sample purity. The minor differences between
Fig. 9.16 PXRD patterns of a EPR, b BET, and EPR–BET obtained by c liquid-assisted grinding
and d solvent evaporation. e Simulated single-crystal pattern of EPR–BET. Reprinted (adapted or
reprinted in part) with permission from [79]. Copyright 2011 American Chemical Society
171
Fig. 9.15 Photoisomerization of EPR accounting for its photoinstability. Reprinted (adapted or
reprinted in part) with permission from [79]. Copyright 2011 American Chemical Society
cases. Therefore, further attempts to obtain pure cocrystals were only conducted
using the above two techniques and a 2:1 EPR/BET molar ratio. As illustrated in
Fig. 9.16, no raw material peaks were observed under these conditions, indicating
the formation of a new phase. In addition, the new PXRD patterns matched well with
the simulated ones, suggesting high sample purity. The minor differences between
Fig. 9.16 PXRD patterns of a EPR, b BET, and EPR–BET obtained by c liquid-assisted grinding
and d solvent evaporation. e Simulated single-crystal pattern of EPR–BET. Reprinted (adapted or
reprinted in part) with permission from [79]. Copyright 2011 American Chemical Society