Table 1 Crystal structures of PfDHODH with various inhibitors, year of publication, resolution
and enzyme inhibitory acitivity (IC 50 ) in µM
Sr. No PDB
ID
Hit structures
Year Resolution
(Å)
Pf IC 50
(µM)
Hs IC 50
(µM)
Refs.
1
1TV5
2005 2.40
190.1
0.26
[62]
2
3I6R
2009 2.50
0.28
>100
[64]
3
3I65
2009 2.00
0.047
>100
[64]
4
3I68
2009 2.40
0.056
>100
[64]
5
3O8A
2010 2.30
0.022
>30
[65]
6
3SFK
2011 2.90 Å
0.038
>100
[66]
7
4CQ8
2014 1.98
0.08
>30
[67]
8
4CQ9
2014 2.72
3.5
3.8
[67]
9
4CQA
2014 2.82
13.5
>30
[67]
10
4ORM
2014 2.07
0.022
1.6
[68]
11
4RX0
2015 2.25
0.033
>100
[69]
(continued)
192
S. Bhagat et al.