Na G, Fang X, Cai Y et al (2013) Occurrence, distribution, and bioaccumulation of antibiotics in
coastal environment of Dalian, China. Mar Pollut Bull 69:233–237
Naslund J, Hedman JE, Agestrand C (2008) Effects of the antibiotic ciprofloxacin on the bacterial
community structure and degradation of pyrene in marine sediment. Aquat Toxicol 90:223–227
Opris O, Soran ML, Coman V (2013) Determination of some frequently used antibiotics in waste
water using solid phase extraction followed by high performance liquid chromatography with
diode array and mass spectrometry detection. Cent Eur J Chem 11:1343–1351
Orya J, Bricheux G, Togola A et al (2016) Ciprofloxacin residue and antibiotic-resistant biofilm
bacteria in hospital effluent. Environ Pollut 214:635–645
Östman M, Lindberg RH, Fick J et al (2017) Screening of biocides, metals and antibiotics in
Swedish sewage sludge and wastewater. Water Res 115:318–328
Park J, Kim MH, Choi K et al (2007) Environmental risk assessment of pharmaceuticals: model
application for estimating pharmaceutical exposures in the Han River Basin, Re-06. Korea
Environment Institute, p 201
Pauwels B, Verstraete W (2006) The treatment of hospital wastewater: an appraisal. Water Health
4:405–416
Pei R, Kim SC, Carlson KH et al (2006) Effect of river landscape on the sediment concentrations of
antibiotics and corresponding antibiotic resistance genes (ARG). Water Res 40:2427–2435.
https://doi.org/10.1016/j.watres.2006.04.017
Peng X, Yu Y, Tang C et al (2008) Occurrence of steroid estrogens, endocrine-disrupting phenols,
and acid pharmaceutical residues in urban riverine water of the Pearl River Delta. South China
Sci Total Environ 397:158–166
Peng X, Tang C, Yu Y et al (2009) Concentrations, transport, fate, and releases of polybrominated
diphenyl ethers in sewage treatment plants in the Pearl River Delta, South China. Environ Int
35:303–309
Peng X, Zhang K, Tang C et al (2011) Distribution pattern, behavior and fate of antibacterials in
urban aquatic environments in South China. J Environ Monit 13:446–454
Peterson LR (2008) Currently available antimicrobial agents and their potential for use as
monotherapy. Clin Microbial Infect 14:30–45
Poirel L, Brinas L, Verlinde A et al (2005) BEL-1, a novel clavulanic acid-inhibited extendedspectrum beta-lactamase, and the class 1 integron In120 in Pseudomonas aeruginosa.
Antimicrob Agents Chemother 49:3743–3748
Polk RE, Johnson CK, McClish D et al (2004) Predicting hospital rates of fluoroquinolone-resistant
Pseudomonas Aeruginosa from fluoroquinolone use in US hospitals and their surrounding
communities. Clin Infect Dis 39:497–503. https://doi.org/10.1086/422647
Pomati F, Netting AG, Calamari D et al (2004) Effects of erythromycin, tetracycline and ibuprofen
on the growth of Synechocysrissp. and Lemma minor. Aquat Toxicol 67:387–396
Proia L, Lupini G, Osorio V et al (2013) Response of biofilm bacterial communities to antibiotic
pollutants in a Mediterranean river. Chemosphere 92:1126–1135
Pruden A, Larsson DGJ, Amezquita A et al (2013) Management options for reducing the release of
antibiotics and antibiotic resistance genes to the environment. Environ Health Perspect
121:878–885
Quanten L, Chaerle L, Noben JP et al (2007) Effects of tetracycline on wild-type and inducible
P35So IPT-5/TETR transgenic tobacco plants. Physiol Plant 130:290–300
Reddersen K, Heberer T, Dünnbier U (2002) Identification and significance of phenazone drugs and
their metabolites in ground and drinking water. Chemosphere 49:539–544
Reinthaler FF, Posch J, Feierl G et al (2003) Antibiotic resistance of E. Coli in sewage and sludge.
Water Res 37:1685–1690. https://doi.org/10.1016/S0043-1354(02)00569-9
Renew JE, Huang CH (2004) Simultaneous determination of fluoroquinolone, sulfonamide, and
trimethoprim antibiotics in wastewater using tandem solid phase extraction and liquid
chromatography–electrospray mass spectrometry. J Chromatogr A 1042:113–121. https://doi.
org/10.1016/j.chroma.2004.05.056
Rizzo L, Manaia C, Merlin C et al (2013) Urban wastewater treatment plants as hotspots for
antibiotic resistant bacteria and genes spread into the environment: a review. Sci Total Environ
447:345–360
66
H. H. Al-Haideri et al.
coastal environment of Dalian, China. Mar Pollut Bull 69:233–237
Naslund J, Hedman JE, Agestrand C (2008) Effects of the antibiotic ciprofloxacin on the bacterial
community structure and degradation of pyrene in marine sediment. Aquat Toxicol 90:223–227
Opris O, Soran ML, Coman V (2013) Determination of some frequently used antibiotics in waste
water using solid phase extraction followed by high performance liquid chromatography with
diode array and mass spectrometry detection. Cent Eur J Chem 11:1343–1351
Orya J, Bricheux G, Togola A et al (2016) Ciprofloxacin residue and antibiotic-resistant biofilm
bacteria in hospital effluent. Environ Pollut 214:635–645
Östman M, Lindberg RH, Fick J et al (2017) Screening of biocides, metals and antibiotics in
Swedish sewage sludge and wastewater. Water Res 115:318–328
Park J, Kim MH, Choi K et al (2007) Environmental risk assessment of pharmaceuticals: model
application for estimating pharmaceutical exposures in the Han River Basin, Re-06. Korea
Environment Institute, p 201
Pauwels B, Verstraete W (2006) The treatment of hospital wastewater: an appraisal. Water Health
4:405–416
Pei R, Kim SC, Carlson KH et al (2006) Effect of river landscape on the sediment concentrations of
antibiotics and corresponding antibiotic resistance genes (ARG). Water Res 40:2427–2435.
https://doi.org/10.1016/j.watres.2006.04.017
Peng X, Yu Y, Tang C et al (2008) Occurrence of steroid estrogens, endocrine-disrupting phenols,
and acid pharmaceutical residues in urban riverine water of the Pearl River Delta. South China
Sci Total Environ 397:158–166
Peng X, Tang C, Yu Y et al (2009) Concentrations, transport, fate, and releases of polybrominated
diphenyl ethers in sewage treatment plants in the Pearl River Delta, South China. Environ Int
35:303–309
Peng X, Zhang K, Tang C et al (2011) Distribution pattern, behavior and fate of antibacterials in
urban aquatic environments in South China. J Environ Monit 13:446–454
Peterson LR (2008) Currently available antimicrobial agents and their potential for use as
monotherapy. Clin Microbial Infect 14:30–45
Poirel L, Brinas L, Verlinde A et al (2005) BEL-1, a novel clavulanic acid-inhibited extendedspectrum beta-lactamase, and the class 1 integron In120 in Pseudomonas aeruginosa.
Antimicrob Agents Chemother 49:3743–3748
Polk RE, Johnson CK, McClish D et al (2004) Predicting hospital rates of fluoroquinolone-resistant
Pseudomonas Aeruginosa from fluoroquinolone use in US hospitals and their surrounding
communities. Clin Infect Dis 39:497–503. https://doi.org/10.1086/422647
Pomati F, Netting AG, Calamari D et al (2004) Effects of erythromycin, tetracycline and ibuprofen
on the growth of Synechocysrissp. and Lemma minor. Aquat Toxicol 67:387–396
Proia L, Lupini G, Osorio V et al (2013) Response of biofilm bacterial communities to antibiotic
pollutants in a Mediterranean river. Chemosphere 92:1126–1135
Pruden A, Larsson DGJ, Amezquita A et al (2013) Management options for reducing the release of
antibiotics and antibiotic resistance genes to the environment. Environ Health Perspect
121:878–885
Quanten L, Chaerle L, Noben JP et al (2007) Effects of tetracycline on wild-type and inducible
P35So IPT-5/TETR transgenic tobacco plants. Physiol Plant 130:290–300
Reddersen K, Heberer T, Dünnbier U (2002) Identification and significance of phenazone drugs and
their metabolites in ground and drinking water. Chemosphere 49:539–544
Reinthaler FF, Posch J, Feierl G et al (2003) Antibiotic resistance of E. Coli in sewage and sludge.
Water Res 37:1685–1690. https://doi.org/10.1016/S0043-1354(02)00569-9
Renew JE, Huang CH (2004) Simultaneous determination of fluoroquinolone, sulfonamide, and
trimethoprim antibiotics in wastewater using tandem solid phase extraction and liquid
chromatography–electrospray mass spectrometry. J Chromatogr A 1042:113–121. https://doi.
org/10.1016/j.chroma.2004.05.056
Rizzo L, Manaia C, Merlin C et al (2013) Urban wastewater treatment plants as hotspots for
antibiotic resistant bacteria and genes spread into the environment: a review. Sci Total Environ
447:345–360
66
H. H. Al-Haideri et al.