Hammesfahr U, Bierl R, Thiele-Bruhn S (2011) Combined effects of the antibiotic sulfadiazine and
liquid manure on the soil microbial-community structure and functions. J Plant Nutr Soil Sci
174:614–623
Hannaa N, Sunb P, Sunc Q et al (2018) Presence of antibiotic residues in various environmental
compartments of Shandong province in eastern China: its potential for resistance development
and ecological and human risk. Environ Int 114:131–142
Heise J, Höltge S, Schrader S et al (2006) Chemical and biological characterization of
non-extractable sulfonamide residues in soil. Chemosphere 65:2352–2357
Heuer H, Focks A, Lamshoft M et al (2008) Fate of sulfadiazine administered to pigs and its
quantitative effect on the dynamics of bacterial resistance genes in manure and manured soil.
Soil Biol Biochem 40:1892–1900
Higgins PG, Fluit AC, Schmitz FJ (2003) Fluoroquinolones: structure and target sites. Curr Drug
Targets 4:181–190
Hillis DG, Fletcher J, Solomon KR et al (2011) Effects of ten antibiotics on seed germination and
root elongation in three plant species. Arch Environ Contam Toxicol 60:220–232
Hocquet D, Muller A, Bertrand X (2016) What happens in hospitals does not stay in hospitals:
antibiotic-resistant bacteria in hospital wastewater systems. J Hosp Infect 93:395–402
Holling CS, Bailey JL, Vanden Heuvel B, Kinney CA (2012) Uptake of human pharmaceuticals
and personal care products by cabbage (Brassica campestris) from fortified and biosolidsamended soils. J Environ Monit 14:3029. https://doi.org/10.1039/c2em30456b
Hou L, Yin G, Liu M et al (2015) Effects of sulfamethazine on denitrification and the associated
N 2 O release in estuarine and coastal sediments. Environ Sci Technol 49:326–333
Hu J, Shi J, Chang H et al (2008) Phenotyping and genotyping of antibiotic-resistant Escherichia
Coli isolated from a Natural River basin. Environ Sci Technol 42:3415–3420. https://doi.org/10.
1021/es7026746
Hu X, Zhou Q, Lou Y (2010) Occurrence and source analysis of typical veterinary antibiotics in
manure, soil, vegetables and groundwater from organic vegetable bases, Northern China.
Environ Pollut 158:2992–2998
Huerta-Fontela M, Teresa Galceran M, Ventura F (2011) Occurrence and removal of pharmaceuticals and hormones through drinking water treatment. Water Res 45:1432–1442
Hund-Rinke K, Simon M, Lukow T (2004) Effects of tetracycline on the soil microflora: function,
diversity, resistance. J Soils Sediments 4:11–16
Ji X, Shen Q, Liu F et al (2012) Antibiotic resistance gene abundances associated with antibiotics
and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai;
China. J Hazard Mater 235–236:178–185
Jia A, Wan Y, Xiao Y et al (2012) Occurrence and fate of quinolone and fluoroquinolone antibiotics
in a municipal sewage treatment plant. Water Res 46:387–394
Jjemba P (2002) The potential impact of veterinary and human therapeutic agents in manure and
biosolids on vegetation: a review. Agric Ecosyst Environ 93:267–278
Jjemba PK (2006) Excretion and ecotoxicity of pharmaceutical and personal care products in the
environment. Ecotoxicol Environ Saf 63:113–130
Jones O, Voulvoulis N, Lester J (2002) Aquatic environmental assessment of the top 25 English
prescription pharmaceuticals. Water Res 36:5013–5022
Ju F, Beck K, Yin X et al (2019) Wastewater treatment plant resistomes are shaped by bacterial
composition, genetic exchange, and upregulated expression in the effuent microbiomes. ISME J
13:346–360
Jurado A, Vazquez-Sune E, Carrera J et al (2012) Emerging organic contaminants in groundwater in
Spain: a review of sources, recent occurrence and fate in a European context. Sci Total Environ
440:82–94
Kanda R, Griffin P, James H et al (2003) Pharmaceutical and personal care products in Sewage
treatment works. J Environ Monit 5:823–830
Kapoor G, Saigal S, Elongavan A (2017) Action and resistance mechanisms of antibiotics: A guide
for clinicians. J Anaesthesiol Clin Pharmacol 33:300–305
3 Existence of Antibiotics in Wastewater as a Pollution Indicator
63
liquid manure on the soil microbial-community structure and functions. J Plant Nutr Soil Sci
174:614–623
Hannaa N, Sunb P, Sunc Q et al (2018) Presence of antibiotic residues in various environmental
compartments of Shandong province in eastern China: its potential for resistance development
and ecological and human risk. Environ Int 114:131–142
Heise J, Höltge S, Schrader S et al (2006) Chemical and biological characterization of
non-extractable sulfonamide residues in soil. Chemosphere 65:2352–2357
Heuer H, Focks A, Lamshoft M et al (2008) Fate of sulfadiazine administered to pigs and its
quantitative effect on the dynamics of bacterial resistance genes in manure and manured soil.
Soil Biol Biochem 40:1892–1900
Higgins PG, Fluit AC, Schmitz FJ (2003) Fluoroquinolones: structure and target sites. Curr Drug
Targets 4:181–190
Hillis DG, Fletcher J, Solomon KR et al (2011) Effects of ten antibiotics on seed germination and
root elongation in three plant species. Arch Environ Contam Toxicol 60:220–232
Hocquet D, Muller A, Bertrand X (2016) What happens in hospitals does not stay in hospitals:
antibiotic-resistant bacteria in hospital wastewater systems. J Hosp Infect 93:395–402
Holling CS, Bailey JL, Vanden Heuvel B, Kinney CA (2012) Uptake of human pharmaceuticals
and personal care products by cabbage (Brassica campestris) from fortified and biosolidsamended soils. J Environ Monit 14:3029. https://doi.org/10.1039/c2em30456b
Hou L, Yin G, Liu M et al (2015) Effects of sulfamethazine on denitrification and the associated
N 2 O release in estuarine and coastal sediments. Environ Sci Technol 49:326–333
Hu J, Shi J, Chang H et al (2008) Phenotyping and genotyping of antibiotic-resistant Escherichia
Coli isolated from a Natural River basin. Environ Sci Technol 42:3415–3420. https://doi.org/10.
1021/es7026746
Hu X, Zhou Q, Lou Y (2010) Occurrence and source analysis of typical veterinary antibiotics in
manure, soil, vegetables and groundwater from organic vegetable bases, Northern China.
Environ Pollut 158:2992–2998
Huerta-Fontela M, Teresa Galceran M, Ventura F (2011) Occurrence and removal of pharmaceuticals and hormones through drinking water treatment. Water Res 45:1432–1442
Hund-Rinke K, Simon M, Lukow T (2004) Effects of tetracycline on the soil microflora: function,
diversity, resistance. J Soils Sediments 4:11–16
Ji X, Shen Q, Liu F et al (2012) Antibiotic resistance gene abundances associated with antibiotics
and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai;
China. J Hazard Mater 235–236:178–185
Jia A, Wan Y, Xiao Y et al (2012) Occurrence and fate of quinolone and fluoroquinolone antibiotics
in a municipal sewage treatment plant. Water Res 46:387–394
Jjemba P (2002) The potential impact of veterinary and human therapeutic agents in manure and
biosolids on vegetation: a review. Agric Ecosyst Environ 93:267–278
Jjemba PK (2006) Excretion and ecotoxicity of pharmaceutical and personal care products in the
environment. Ecotoxicol Environ Saf 63:113–130
Jones O, Voulvoulis N, Lester J (2002) Aquatic environmental assessment of the top 25 English
prescription pharmaceuticals. Water Res 36:5013–5022
Ju F, Beck K, Yin X et al (2019) Wastewater treatment plant resistomes are shaped by bacterial
composition, genetic exchange, and upregulated expression in the effuent microbiomes. ISME J
13:346–360
Jurado A, Vazquez-Sune E, Carrera J et al (2012) Emerging organic contaminants in groundwater in
Spain: a review of sources, recent occurrence and fate in a European context. Sci Total Environ
440:82–94
Kanda R, Griffin P, James H et al (2003) Pharmaceutical and personal care products in Sewage
treatment works. J Environ Monit 5:823–830
Kapoor G, Saigal S, Elongavan A (2017) Action and resistance mechanisms of antibiotics: A guide
for clinicians. J Anaesthesiol Clin Pharmacol 33:300–305
3 Existence of Antibiotics in Wastewater as a Pollution Indicator
63