139. Kang JW, So PTC, Dasari RR, Lim D-K (2015) High resolution live cell Raman imaging
using subcellular organelle-targeting sers-sensitive gold nanoparticles with highly narrow
intra-nanogap. Nano Lett 15:1766–1772
140. Xu L, Zhao S, Ma W, Wu X, Li S, Kuang H, Wang L, Xu C (2016) Multigaps embedded
nanoassemblies enhance in situ Raman spectroscopy for intracellular telomerase activity
sensing. Adv Funct Mater 26:1602–1608
141. Kaur G, Dufour JM (2012) Cell lines: valuable tools or useless artifacts. Spermatogenesis
2:1–5
142. Pan C, Kumar C, Bohl S, Klingmueller U, Mann M (2009) Comparative proteomic
phenotyping of cell lines and primary cells to assess preservation of cell type-specific
functions. Mol Cell Proteomics 8:443–450
143. Maslak E, Gregorius A, Chlopicki S (2015) Liver sinusoidal endothelial cells (LSECs)
function and NAFLD; NO-based therapy targeted to the liver. Pharmacol Rep 67:689–694
144. Edelberg JM, Aird WC, Wu W, Rayburn H, Mamuya WS, Mercola M, Rosenberg RD
(1998) PDGF mediates cardiac microvascular communication. J Clin Invest 102:837–843
145. Wayhart JP, Lawson HA (2017) Animal models of metabolic syndrome A2. In: Conn P,
Michael BT (eds) Animal models for the study of human disease. 2nd edn. Academic Press,
pp 221–243 (Chapter 9)
146. Sørensen KK, Simon-Santamaria J, McCuskey RS, Smedsrød B (2011) Liver sinusoidal
endothelial cells. Compr Physiol 5:1751–1774
147. Wisse E (1972) An ultrastructural characterization of the endothelial cell in the rat liver
sinusoid under normal and various experimental conditions, as a contribution to the
distinction between endothelial and Kupffer cells. J Ultrastruct Res 38:528–562
148. Elvevold K, Smedsrod B, Martinez I (2008) The liver sinusoidal endothelial cell: a cell type
of controversial and confusing identity. Am J Physiol Gastrointest Liver Physiol 294:
G391–G400
149. Meyer J, Lacotte S, Morel P, Gonelle-Gispert C, Bühler L (2016) An optimized method for
mouse liver sinusoidal endothelial cell isolation. Exp Cell Res 349:291–301
150. Schie IW, Wu J, Weeks T, Zern MA, Rutledge JC, Huser T (2011) Label-free
characterization of rapid lipid accumulation in living primary hepatocytes after exposure
to lipoprotein lipolysis products. J Biophotonics 4:425–434
151. Testerink N, Ajat M, Houweling M, Brouwers JF, Pully VV, van Manen H-J, Otto C,
Helms JB, Vaandrager AB (2012) Replacement of retinyl esters by polyunsaturated
triacylglycerol species in lipid droplets of hepatic stellate cells during activation. PLoS ONE
7:e34945
152. Kochan K, Kus E, Filipek A, Szafrańska K, Chlopicki S, Baranska M (2017) Label-free
spectroscopic characterization of live liver sinusoidal endothelial cells (LSECs) isolated from
the murine liver. Analyst 142:1308–1319
153. Huebert RC, Jagavelu K, Liebl AF, Huang BQ, Splinter PL, LaRusso NF, Urrutia RA (2010)
Immortalized liver endothelial cells: a cell culture model for studies of motility and
angiogenesis. Lab Invest 90:1770–1781
154. Brutsaert DL (2003) Cardiac endothelial-myocardial signaling: its role in cardiac growth,
contractile performance, and rhythmicity. Physiol Rev 83:59–115
155. Tirziu D, Giordano FJ, Simons M (2010) Cell communications in the heart. Circulation
122:928–937
156. Lee JF, Barrett-O’Keefe Z, Garten RS, Nelson AD, Ryan JJ, Nativi JN, Richardson RS,
Wray DW (2016) Evidence of microvascular dysfunction in heart failure with preserved
ejection fraction. Heart 102:278–284
157. Garlanda C, Parravicini C, Sironi M, DeRossi M, Wainstok de Calmanovici R, Carozzi F,
Bussolino F, Colotta F, Mantovani A, Vecchi A (1994) Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma
middle-sized T antigen: implications for the pathogenesis of opportunistic vascular tumors.
Proc Natl Acad Sci U S A 91:7291–7295
6 Small and Large Molecules Investigated by Raman Spectroscopy
195
using subcellular organelle-targeting sers-sensitive gold nanoparticles with highly narrow
intra-nanogap. Nano Lett 15:1766–1772
140. Xu L, Zhao S, Ma W, Wu X, Li S, Kuang H, Wang L, Xu C (2016) Multigaps embedded
nanoassemblies enhance in situ Raman spectroscopy for intracellular telomerase activity
sensing. Adv Funct Mater 26:1602–1608
141. Kaur G, Dufour JM (2012) Cell lines: valuable tools or useless artifacts. Spermatogenesis
2:1–5
142. Pan C, Kumar C, Bohl S, Klingmueller U, Mann M (2009) Comparative proteomic
phenotyping of cell lines and primary cells to assess preservation of cell type-specific
functions. Mol Cell Proteomics 8:443–450
143. Maslak E, Gregorius A, Chlopicki S (2015) Liver sinusoidal endothelial cells (LSECs)
function and NAFLD; NO-based therapy targeted to the liver. Pharmacol Rep 67:689–694
144. Edelberg JM, Aird WC, Wu W, Rayburn H, Mamuya WS, Mercola M, Rosenberg RD
(1998) PDGF mediates cardiac microvascular communication. J Clin Invest 102:837–843
145. Wayhart JP, Lawson HA (2017) Animal models of metabolic syndrome A2. In: Conn P,
Michael BT (eds) Animal models for the study of human disease. 2nd edn. Academic Press,
pp 221–243 (Chapter 9)
146. Sørensen KK, Simon-Santamaria J, McCuskey RS, Smedsrød B (2011) Liver sinusoidal
endothelial cells. Compr Physiol 5:1751–1774
147. Wisse E (1972) An ultrastructural characterization of the endothelial cell in the rat liver
sinusoid under normal and various experimental conditions, as a contribution to the
distinction between endothelial and Kupffer cells. J Ultrastruct Res 38:528–562
148. Elvevold K, Smedsrod B, Martinez I (2008) The liver sinusoidal endothelial cell: a cell type
of controversial and confusing identity. Am J Physiol Gastrointest Liver Physiol 294:
G391–G400
149. Meyer J, Lacotte S, Morel P, Gonelle-Gispert C, Bühler L (2016) An optimized method for
mouse liver sinusoidal endothelial cell isolation. Exp Cell Res 349:291–301
150. Schie IW, Wu J, Weeks T, Zern MA, Rutledge JC, Huser T (2011) Label-free
characterization of rapid lipid accumulation in living primary hepatocytes after exposure
to lipoprotein lipolysis products. J Biophotonics 4:425–434
151. Testerink N, Ajat M, Houweling M, Brouwers JF, Pully VV, van Manen H-J, Otto C,
Helms JB, Vaandrager AB (2012) Replacement of retinyl esters by polyunsaturated
triacylglycerol species in lipid droplets of hepatic stellate cells during activation. PLoS ONE
7:e34945
152. Kochan K, Kus E, Filipek A, Szafrańska K, Chlopicki S, Baranska M (2017) Label-free
spectroscopic characterization of live liver sinusoidal endothelial cells (LSECs) isolated from
the murine liver. Analyst 142:1308–1319
153. Huebert RC, Jagavelu K, Liebl AF, Huang BQ, Splinter PL, LaRusso NF, Urrutia RA (2010)
Immortalized liver endothelial cells: a cell culture model for studies of motility and
angiogenesis. Lab Invest 90:1770–1781
154. Brutsaert DL (2003) Cardiac endothelial-myocardial signaling: its role in cardiac growth,
contractile performance, and rhythmicity. Physiol Rev 83:59–115
155. Tirziu D, Giordano FJ, Simons M (2010) Cell communications in the heart. Circulation
122:928–937
156. Lee JF, Barrett-O’Keefe Z, Garten RS, Nelson AD, Ryan JJ, Nativi JN, Richardson RS,
Wray DW (2016) Evidence of microvascular dysfunction in heart failure with preserved
ejection fraction. Heart 102:278–284
157. Garlanda C, Parravicini C, Sironi M, DeRossi M, Wainstok de Calmanovici R, Carozzi F,
Bussolino F, Colotta F, Mantovani A, Vecchi A (1994) Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma
middle-sized T antigen: implications for the pathogenesis of opportunistic vascular tumors.
Proc Natl Acad Sci U S A 91:7291–7295
6 Small and Large Molecules Investigated by Raman Spectroscopy
195