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122. Jaworska A, Wojcik T, Malek K, Kwolek U, Kepczynski M, Ansary AA, Chlopicki S,
Baranska M (2015) Rhodamine 6G conjugated to gold nanoparticles as labels for both SERS
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of cellular compartments with gold nanoparticles and nanoaggregates. Nano Lett 6:
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124. Panikkanvalappil SR, Hira SM, El-Sayed MA (2016) Elucidation of ultraviolet
radiation-induced cell responses and intracellular biomolecular dynamics in mammalian
cells using surface-enhanced Raman spectroscopy. Chem Sci 7:1133–1141
125. Huang J, Zong C, Shen H, Cao U, Ren B, Zhang Z (2013) Tracking the intracellular drug
release from graphene oxide using surface-enhanced Raman spectroscopy. Nanoscale
5:10591–10598
126. Kim JH, Kim JS, Choi H, Lee SM, Jun BH, Yu KN, Kuk E, Kim YK, Jeong DH, Cho MH,
Lee YS (2006) Nanoparticle probes with surface enhanced Raman spectroscopic tags for
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127. Cialla-May D, Zheng X-S, Weber K, Popp J (2017) Recent progress in surface-enhanced
Raman spectroscopy for biological and biomedical applications: from cells to clinics. Chem
Soc Rev 46:3945–3961
128. Jaworska A, Jamieson LE, Malek K, Campbell CJ, Choo J, Chlopicki S, Baranska M (2015)
SERS-based monitoring of the intracellular pH in endothelial cells: the influence of the
extracellular environment and tumour necrosis factor-a. Analyst 140:2321–2329
129. Talley CE, Jusinski L, Hollars CW, Lane SM, Huser T (2004) Intracellular pH sensors based
on surface-enhanced Raman scattering. Anal Chem 76:7064–7068
130. Wang F, Widejko RG, Yang Z, Nguyen KT, Chen H, Fernando LP, Christensen KA,
Anker JN (2012) Surface-enhanced Raman scattering detection of pH with
silica-encapsulated 4-mercaptobenzoic acid-functionalized silver nanoparticles. Anal Chem
84:8013–8019
131. Wei H, Willner MR, Marr LC, Vikesland PJ (2016) Highly stable SERS pH nanoprobes
produced by co-solvent controlled AuNP aggregation. Analyst 141:5159–5169
132. Lim JK, Joo S-W (2006) Gold nanoparticle-based pH sensor in highly alkaline region at
pH > 11: surface-enhanced Raman scattering study. Appl Spectrosc 60:847–852
133. Wang Z, Bonoiu A, Samoc M, Cui Y, Prasad PN (2008) Biological pH sensing based on
surface enhanced Raman scattering through a 2-aminothiophenol-silver probe. Biosens
Bioelectron 23:886–891
134. Chen P, Wang Z, Zong S, Zhu D, Chen H, Zhang Y, Wu L, Cui Y (2016) pH-sensitive
nanocarrier based on gold/silver core–shell nanoparticles decorated multi-walled carbon
manotubes for tracing drug release in living cells. Biosens Bioelectron 75:446–451
135. Song J, Zhou J, Duan H (2012) Self-assembled plasmonic vesicles of SERS-Encoded
amphiphilic gold nanoparticles for cancer cell targeting and traceable intracellular drug
delivery. J Am Chem Soc 134:13458–13469
136. Bobba KN, Saranya G, Alex SM, Velusamy N, Maiti KK, Bhuniya S (2018) SERS-active
multi-channel fluorescent probe for NO: guide to discriminate intracellular biothiols. Sensors
Actuators B Chem 260:165–173
137. Cao Y, Li DW, Zhao LJ, Liu XY, Cao XM, Long YT (2015) Highly selective detection of
carbon monoxide in living cells by palladacycle carbonylation-based surface enhanced
raman spectroscopy nanosensors. Anal Chem 87:9696–9701
138. Pissuwan D, Hobro AJ, Pavillon N, Smith NI (2014) Distribution of label free cationic
polymer-coated gold nanorods in live macrophage cells reveals formation of groups of
intracellular SERS signals of probe nanoparticles. RSC Adv 4:5536
194
K. Czamara et al.
detection of living cells by surface-enhanced Raman spectroscopy. Chem Commun
47:5738–5740
121. Taylor J, Huefner A, Li L, Wingfieldc J, Mahajan S (2016) Nanoparticles and intracellular
applications of surface-enhanced Raman spectroscopy. Analyst 141:5037–5055
122. Jaworska A, Wojcik T, Malek K, Kwolek U, Kepczynski M, Ansary AA, Chlopicki S,
Baranska M (2015) Rhodamine 6G conjugated to gold nanoparticles as labels for both SERS
and fluorescence studies on live endothelial cells. Microchim Acta 182:119–127
123. Kneipp J, Kneipp H, McLaughlin M, Brown D, Kneipp K (2006) In vivo molecular probing
of cellular compartments with gold nanoparticles and nanoaggregates. Nano Lett 6:
2225–2231
124. Panikkanvalappil SR, Hira SM, El-Sayed MA (2016) Elucidation of ultraviolet
radiation-induced cell responses and intracellular biomolecular dynamics in mammalian
cells using surface-enhanced Raman spectroscopy. Chem Sci 7:1133–1141
125. Huang J, Zong C, Shen H, Cao U, Ren B, Zhang Z (2013) Tracking the intracellular drug
release from graphene oxide using surface-enhanced Raman spectroscopy. Nanoscale
5:10591–10598
126. Kim JH, Kim JS, Choi H, Lee SM, Jun BH, Yu KN, Kuk E, Kim YK, Jeong DH, Cho MH,
Lee YS (2006) Nanoparticle probes with surface enhanced Raman spectroscopic tags for
cellular cancer targeting. Anal Chem 78:6967–6973
127. Cialla-May D, Zheng X-S, Weber K, Popp J (2017) Recent progress in surface-enhanced
Raman spectroscopy for biological and biomedical applications: from cells to clinics. Chem
Soc Rev 46:3945–3961
128. Jaworska A, Jamieson LE, Malek K, Campbell CJ, Choo J, Chlopicki S, Baranska M (2015)
SERS-based monitoring of the intracellular pH in endothelial cells: the influence of the
extracellular environment and tumour necrosis factor-a. Analyst 140:2321–2329
129. Talley CE, Jusinski L, Hollars CW, Lane SM, Huser T (2004) Intracellular pH sensors based
on surface-enhanced Raman scattering. Anal Chem 76:7064–7068
130. Wang F, Widejko RG, Yang Z, Nguyen KT, Chen H, Fernando LP, Christensen KA,
Anker JN (2012) Surface-enhanced Raman scattering detection of pH with
silica-encapsulated 4-mercaptobenzoic acid-functionalized silver nanoparticles. Anal Chem
84:8013–8019
131. Wei H, Willner MR, Marr LC, Vikesland PJ (2016) Highly stable SERS pH nanoprobes
produced by co-solvent controlled AuNP aggregation. Analyst 141:5159–5169
132. Lim JK, Joo S-W (2006) Gold nanoparticle-based pH sensor in highly alkaline region at
pH > 11: surface-enhanced Raman scattering study. Appl Spectrosc 60:847–852
133. Wang Z, Bonoiu A, Samoc M, Cui Y, Prasad PN (2008) Biological pH sensing based on
surface enhanced Raman scattering through a 2-aminothiophenol-silver probe. Biosens
Bioelectron 23:886–891
134. Chen P, Wang Z, Zong S, Zhu D, Chen H, Zhang Y, Wu L, Cui Y (2016) pH-sensitive
nanocarrier based on gold/silver core–shell nanoparticles decorated multi-walled carbon
manotubes for tracing drug release in living cells. Biosens Bioelectron 75:446–451
135. Song J, Zhou J, Duan H (2012) Self-assembled plasmonic vesicles of SERS-Encoded
amphiphilic gold nanoparticles for cancer cell targeting and traceable intracellular drug
delivery. J Am Chem Soc 134:13458–13469
136. Bobba KN, Saranya G, Alex SM, Velusamy N, Maiti KK, Bhuniya S (2018) SERS-active
multi-channel fluorescent probe for NO: guide to discriminate intracellular biothiols. Sensors
Actuators B Chem 260:165–173
137. Cao Y, Li DW, Zhao LJ, Liu XY, Cao XM, Long YT (2015) Highly selective detection of
carbon monoxide in living cells by palladacycle carbonylation-based surface enhanced
raman spectroscopy nanosensors. Anal Chem 87:9696–9701
138. Pissuwan D, Hobro AJ, Pavillon N, Smith NI (2014) Distribution of label free cationic
polymer-coated gold nanorods in live macrophage cells reveals formation of groups of
intracellular SERS signals of probe nanoparticles. RSC Adv 4:5536
194
K. Czamara et al.