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159. Ogawa M, Harada Y, Yamaoka Y, Fujita K, Yaku H, Takamatsu T (2009) Label-free
biochemical imaging of heart tissue with high-speed spontaneous Raman microscopy.
Biochem Biophys Res Commun 382:370–374
160. Wood BR, Asghari-Khiavi M, Bailo E, McNaughton D, Deckert V (2012) Detection of
nano-oxidation sites on the surface of hemoglobin crystals using tip-enhanced Raman
scattering. Nano Lett 12:1555–1560
161. Kallaway C, Almond LM, Barr H, Wood J, Hutchings J, Kendall C, Stone N (2013)
Advances in the clinical application of Raman spectroscopy for cancer diagnostics.
Photodiagnosis Photodyn Ther 10:207–219
162. Galli R, Uckermann O, Koch E, Schackert G, Kirsch M, Steiner G (2013) Effects of tissue
fixation on coherent anti-Stokes Raman scattering images of brain. J Biomed Opt 19:071402
163. Mariani MM, Lampen P, Popp J, Wood BR, Deckert V (2009) Impact of fixation on in vitro
cell culture lines monitored with Raman spectroscopy. Analyst 134:1154–1161
164. Kong K, Kendall C, Stone N, Notingher I (2015) Raman spectroscopy for medical
diagnostics—from in-vitro biofluid assays to in-vivo cancer detection. Adv Drug Deliv Rev
89:121–134
165. Kendall C, Isabelle M, Bazant-Hegemark F, Hutchings J, Orr L, Babrah J, Baker R, Stone N
(2009) Vibrational spectroscopy: a clinical tool for cancer diagnostics. Analyst 134:
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166. Dybas J, Marzec KM, Pacia MZ, Kochan K, Czamara K, Chrabąszcz K, StaniszewskaŚlęzak E, Małek K, Barańska M, Kaczor A (2016) Raman spectroscopy as a sensitive probe
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167. Wrobel TP, Marzec KM, Chlopicki S, Maślak E, Jasztal A, Franczyk-Żarów M,
Czyżyńska-Cichoń I, Moszkowski T, Kostogrys RB, Baranska M (2015) Effects of cow
carbohydrate high protein (LCHP) diet on atherosclerotic plaque phenotype in ApoE/
LDLR
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168. Kochan K, Chrabaszcz K, Szczur B, Maslak E, Dybasa J, Marzec KM (2016) IR and Raman
imaging of murine brains from control and ApoE/LDLR
−/− mice with advanced
atherosclerosis. Analyst 141:5329–5338
169. Zhang J, Fan Y, He M, Ma X, Song Y, Liu M, Xu J (2017) Accuracy of Raman
spectroscopy in differentiating brain tumor from normal brain tissue. Oncotarget 8:
36824–36831
170. Surmacki J, Musial J, Kordek R, Abramczyk H (2013) Raman imaging at biological
interfaces: applications in breast cancer diagnosis. Mol Cancer 12:48
171. Brozek-Pluska B, Musial J, Kordek R, Bailo E, Dieing T, Abramczyk H (2012) Raman
spectroscopy and imaging: applications in human breast cancer diagnosis. Analyst
137:3773–3780
172. Bratchenko IA, Artemyev DN, Myakinin OO, Khristoforova YA, Moryatov AA,
Kozlov SV, Zakharov VP (2017) Combined Raman and autofluorescence ex vivo
diagnostics of skin cancer in near-infrared and visible regions. J Biomed Opt 22:27005
173. Magee ND, Beattie JR, Carland C, Davis R, McManus K, Bradbury I, Fennell DA,
Hamilton PW, Ennis M, McGarvey JJ, Elborn JS (2010) Raman microscopy in the diagnosis
and prognosis of surgically resected nonsmall cell lung cancer. J Biomed Opt 15:026015
174. Andreou C, Neuschmelting V, Tschaharganeh DF, Huang CH, Oseledchyk A, Iacono P,
Karabeber H, Colen RR, Mannelli L, Lowe SW, Kircher MF (2016) Imaging of liver tumors
using surface-enhanced Raman scattering nanoparticles. ACS Nano 10:5015–5026
175. Cm Krishna, Rubina S (2015) Raman spectroscopy in cervical cancers: An update. J Cancer
Res Ther 11:10–17
176. Kamemoto LE, Misra AK, Sharma SK, Goodman MT, Luk H, Dykes AC, Acosta T (2010)
Near-infrared micro-Raman spectroscopy for in vitro detection of cervical cancer. Appl
Spectrosc 64:255–261
196
K. Czamara et al.
spectroscopy can see more: the case of cytochrome c. J Phys Chem C 112:4867–4873
159. Ogawa M, Harada Y, Yamaoka Y, Fujita K, Yaku H, Takamatsu T (2009) Label-free
biochemical imaging of heart tissue with high-speed spontaneous Raman microscopy.
Biochem Biophys Res Commun 382:370–374
160. Wood BR, Asghari-Khiavi M, Bailo E, McNaughton D, Deckert V (2012) Detection of
nano-oxidation sites on the surface of hemoglobin crystals using tip-enhanced Raman
scattering. Nano Lett 12:1555–1560
161. Kallaway C, Almond LM, Barr H, Wood J, Hutchings J, Kendall C, Stone N (2013)
Advances in the clinical application of Raman spectroscopy for cancer diagnostics.
Photodiagnosis Photodyn Ther 10:207–219
162. Galli R, Uckermann O, Koch E, Schackert G, Kirsch M, Steiner G (2013) Effects of tissue
fixation on coherent anti-Stokes Raman scattering images of brain. J Biomed Opt 19:071402
163. Mariani MM, Lampen P, Popp J, Wood BR, Deckert V (2009) Impact of fixation on in vitro
cell culture lines monitored with Raman spectroscopy. Analyst 134:1154–1161
164. Kong K, Kendall C, Stone N, Notingher I (2015) Raman spectroscopy for medical
diagnostics—from in-vitro biofluid assays to in-vivo cancer detection. Adv Drug Deliv Rev
89:121–134
165. Kendall C, Isabelle M, Bazant-Hegemark F, Hutchings J, Orr L, Babrah J, Baker R, Stone N
(2009) Vibrational spectroscopy: a clinical tool for cancer diagnostics. Analyst 134:
1029–1045
166. Dybas J, Marzec KM, Pacia MZ, Kochan K, Czamara K, Chrabąszcz K, StaniszewskaŚlęzak E, Małek K, Barańska M, Kaczor A (2016) Raman spectroscopy as a sensitive probe
of soft tissue composition—imaging of cross-sections of various organs vs. single spectra of
tissue homogenates. Trends Anal Chem 85:117–127
167. Wrobel TP, Marzec KM, Chlopicki S, Maślak E, Jasztal A, Franczyk-Żarów M,
Czyżyńska-Cichoń I, Moszkowski T, Kostogrys RB, Baranska M (2015) Effects of cow
carbohydrate high protein (LCHP) diet on atherosclerotic plaque phenotype in ApoE/
LDLR
−/− mice: FT-IR and Raman imaging. Sci Rep 5:14002
168. Kochan K, Chrabaszcz K, Szczur B, Maslak E, Dybasa J, Marzec KM (2016) IR and Raman
imaging of murine brains from control and ApoE/LDLR
−/− mice with advanced
atherosclerosis. Analyst 141:5329–5338
169. Zhang J, Fan Y, He M, Ma X, Song Y, Liu M, Xu J (2017) Accuracy of Raman
spectroscopy in differentiating brain tumor from normal brain tissue. Oncotarget 8:
36824–36831
170. Surmacki J, Musial J, Kordek R, Abramczyk H (2013) Raman imaging at biological
interfaces: applications in breast cancer diagnosis. Mol Cancer 12:48
171. Brozek-Pluska B, Musial J, Kordek R, Bailo E, Dieing T, Abramczyk H (2012) Raman
spectroscopy and imaging: applications in human breast cancer diagnosis. Analyst
137:3773–3780
172. Bratchenko IA, Artemyev DN, Myakinin OO, Khristoforova YA, Moryatov AA,
Kozlov SV, Zakharov VP (2017) Combined Raman and autofluorescence ex vivo
diagnostics of skin cancer in near-infrared and visible regions. J Biomed Opt 22:27005
173. Magee ND, Beattie JR, Carland C, Davis R, McManus K, Bradbury I, Fennell DA,
Hamilton PW, Ennis M, McGarvey JJ, Elborn JS (2010) Raman microscopy in the diagnosis
and prognosis of surgically resected nonsmall cell lung cancer. J Biomed Opt 15:026015
174. Andreou C, Neuschmelting V, Tschaharganeh DF, Huang CH, Oseledchyk A, Iacono P,
Karabeber H, Colen RR, Mannelli L, Lowe SW, Kircher MF (2016) Imaging of liver tumors
using surface-enhanced Raman scattering nanoparticles. ACS Nano 10:5015–5026
175. Cm Krishna, Rubina S (2015) Raman spectroscopy in cervical cancers: An update. J Cancer
Res Ther 11:10–17
176. Kamemoto LE, Misra AK, Sharma SK, Goodman MT, Luk H, Dykes AC, Acosta T (2010)
Near-infrared micro-Raman spectroscopy for in vitro detection of cervical cancer. Appl
Spectrosc 64:255–261
196
K. Czamara et al.