and root exudate of Zea mays. Biosci Biotechnol Biochem 68(6):1366–1368
14. Mikhlin ED, Radina VP, Dmitrovskii AA, Blinkova LP, Butova LG (1983) Antifungal and
antimicrobial activity of beta-ionone and vitamin a derivatives. Prikl Biokhim Mikrobiol 19
(6):795–803
15. Rodrı ´guez A, Alque ´zar B, Pen ˜a L (2013) Fruit
aromas in mature fleshy fruits as signals of
readiness for predation and seed dispersal.
New Phytol 197(1):36–48. https://doi.org/
10.1111/j.1469-8137.2012.04382.x
16. Rivera-Madrid R, Aguilar-Espinosa M, Ca ´rdenas-Conejo Y, Garza-Caligaris LE (2016)
Carotenoid Derivates in Achiote (Bixa orellana) seeds: synthesis and health promoting
properties. Front Plant Sci 7:1406. https://
doi.org/10.3389/fpls.2016.01406
17. Baldermann S, Yamamoto M, Yang Z,
Kawahashi T, Kuwano K, Watanabe N (2013)
C 13 -Apocarotenoids: more than Flavor compounds? In: Carotenoid cleavage products, vol
1134. ACS symposium series, vol 1134. American Chemical Society, pp 73–80. doi:https://
doi.org/10.1021/bk-2013-1134.ch007
18. Ahrazem O, Rubio-Moraga A, Nebauer SG,
Molina RV, Gomez-Gomez L (2015) Saffron:
its Phytochemistry, developmental processes,
and biotechnological prospects. J Agric Food
Chem 63(40):8751–8764. https://doi.org/
10.1021/acs.jafc.5b03194
19. Harrison PJ, Bugg TD (2014) Enzymology of
the carotenoid cleavage dioxygenases: reaction
mechanisms, inhibition and biochemical roles.
Arch Biochem Biophys 544:105–111. https://
doi.org/10.1016/j.abb.2013.10.005S00039861(13)00307-X. [pii]
20. Ahrazem O, Gomez-Gomez L, Rodrigo MJ,
Avalos J, Limon MC (2016) Carotenoid cleavage Oxygenases from microbes and photosynthetic organisms: features and functions. Int J
Mol Sci 17(11). E1781 [pii]ijms17111781).
https://doi.org/10.3390/ijms17111781
21. Seo M, Koshiba T (2002) Complex regulation
of ABA biosynthesis in plants. Trends Plant Sci
7(1):41–48. [pii]
22. Bruno M, Beyer P, Al-Babili S (2015) The
potato carotenoid cleavage dioxygenase 4 catalyzes a single cleavage of beta-ionone ring-containing
carotenes
and
non-epoxidated
xanthophylls.
Arch
Biochem
Biophys
572:126–133.
S0003-9861(15)00073-9.
https://doi.org/10.1016/j.abb.2015.02.011
23. Bruno M, Vermathen M, Alder A, Wust F,
Schaub P, van der Steen R, Beyer P, Ghisla S,
Al-Babili S (2017) Insights into the formation
of carlactone from in-depth analysis of the
CCD8-catalyzed reactions. FEBS Lett 591
(5):792–800.
https://doi.org/10.1002/
1873-3468.12593
24. Bruno M, Hofmann M, Vermathen M,
Alder A, Beyer P, Al-Babili S (2014) On the
substrate- and stereospecificity of the plant
carotenoid cleavage dioxygenase 7. FEBS Lett
588(9):1802–1807.
https://doi.org/10.
1016/j.febslet.2014.03.041S0014-5793(14)
00260-9. [pii]
25. Frusciante S, Diretto G, Bruno M, Ferrante P,
Pietrella M, Prado-Cabrero A, Rubio-MoragaA, Beyer P, Gomez-Gomez L, Al-Babili S, Giuliano G (2014) Novel carotenoid cleavage
dioxygenase catalyzes the first dedicated step
in saffron crocin biosynthesis. Proc Natl Acad
Sci U S A 111(33):12246–12251. https://doi.
org/10.1073/pnas.
14046291111404629111. [pii]
26. Rodrigo MJ, Alquezar B, Alos E, Medina V,
Carmona L, Bruno M, Al-Babili S, Zacarias L
(2013) A novel carotenoid cleavage activity
involved in the biosynthesis of Citrus fruitspecific apocarotenoid pigments. J Exp Bot 64
(14):4461–4478. ert260 [pii]. https://doi.
org/10.1093/jxb/ert260
27. Ahrazem O, Diretto G, Argandona J, RubioMoraga A, Julve JM, Orzaez D, Granell A,
Gomez-Gomez L (2017) Evolutionarily distinct carotenoid cleavage dioxygenases are
responsible for crocetin production in Buddleja
davidii. J Exp Bot 68(16):4663–4677. https://
doi.org/10.1093/jxb/erx2774068697. [pii]
28. Auldridge ME, McCarty DR, Klee HJ (2006)
Plant carotenoid cleavage oxygenases and their
apocarotenoid products. Curr Opin Plant Biol
9(3):315–321..
S1369-5266(06)00044-6.
https://doi.org/10.1016/j.pbi.2006.03.005
29. Rodriguez-Concepcion M, Avalos J, Bonet
ML, Boronat A, Gomez-Gomez L, HorneroMendez D, Limon MC, Melendez-Martinez
AJ, Olmedilla-Alonso B, Palou A, Ribot J,
Rodrigo MJ, Zacarias L, Zhu C (2018) A
global perspective on carotenoids: metabolism,
biotechnology, and benefits for nutrition and
health. Prog Lipid Res 70:62–93. S0163-7827
(17)30039-5.
https://doi.org/10.1016/j.
plipres.2018.04.004
30. Auldridge ME, Block A, Vogel JT, DabneySmith C, Mila I, Bouzayen M, MagallanesLundback M, DellaPenna D, McCarty DR,
Klee HJ (2006) Characterization of three
members of the Arabidopsis carotenoid cleavage dioxygenase family demonstrates the divergent roles of this multifunctional enzyme
family. Plant J 45(6):982–993. TPJ2666 [pii].
https://doi.org/10.1111/j.1365-313X.
2006.02666.x
72
Lourdes Go ´ mez-Go ´ mez et al.
14. Mikhlin ED, Radina VP, Dmitrovskii AA, Blinkova LP, Butova LG (1983) Antifungal and
antimicrobial activity of beta-ionone and vitamin a derivatives. Prikl Biokhim Mikrobiol 19
(6):795–803
15. Rodrı ´guez A, Alque ´zar B, Pen ˜a L (2013) Fruit
aromas in mature fleshy fruits as signals of
readiness for predation and seed dispersal.
New Phytol 197(1):36–48. https://doi.org/
10.1111/j.1469-8137.2012.04382.x
16. Rivera-Madrid R, Aguilar-Espinosa M, Ca ´rdenas-Conejo Y, Garza-Caligaris LE (2016)
Carotenoid Derivates in Achiote (Bixa orellana) seeds: synthesis and health promoting
properties. Front Plant Sci 7:1406. https://
doi.org/10.3389/fpls.2016.01406
17. Baldermann S, Yamamoto M, Yang Z,
Kawahashi T, Kuwano K, Watanabe N (2013)
C 13 -Apocarotenoids: more than Flavor compounds? In: Carotenoid cleavage products, vol
1134. ACS symposium series, vol 1134. American Chemical Society, pp 73–80. doi:https://
doi.org/10.1021/bk-2013-1134.ch007
18. Ahrazem O, Rubio-Moraga A, Nebauer SG,
Molina RV, Gomez-Gomez L (2015) Saffron:
its Phytochemistry, developmental processes,
and biotechnological prospects. J Agric Food
Chem 63(40):8751–8764. https://doi.org/
10.1021/acs.jafc.5b03194
19. Harrison PJ, Bugg TD (2014) Enzymology of
the carotenoid cleavage dioxygenases: reaction
mechanisms, inhibition and biochemical roles.
Arch Biochem Biophys 544:105–111. https://
doi.org/10.1016/j.abb.2013.10.005S00039861(13)00307-X. [pii]
20. Ahrazem O, Gomez-Gomez L, Rodrigo MJ,
Avalos J, Limon MC (2016) Carotenoid cleavage Oxygenases from microbes and photosynthetic organisms: features and functions. Int J
Mol Sci 17(11). E1781 [pii]ijms17111781).
https://doi.org/10.3390/ijms17111781
21. Seo M, Koshiba T (2002) Complex regulation
of ABA biosynthesis in plants. Trends Plant Sci
7(1):41–48. [pii]
22. Bruno M, Beyer P, Al-Babili S (2015) The
potato carotenoid cleavage dioxygenase 4 catalyzes a single cleavage of beta-ionone ring-containing
carotenes
and
non-epoxidated
xanthophylls.
Arch
Biochem
Biophys
572:126–133.
S0003-9861(15)00073-9.
https://doi.org/10.1016/j.abb.2015.02.011
23. Bruno M, Vermathen M, Alder A, Wust F,
Schaub P, van der Steen R, Beyer P, Ghisla S,
Al-Babili S (2017) Insights into the formation
of carlactone from in-depth analysis of the
CCD8-catalyzed reactions. FEBS Lett 591
(5):792–800.
https://doi.org/10.1002/
1873-3468.12593
24. Bruno M, Hofmann M, Vermathen M,
Alder A, Beyer P, Al-Babili S (2014) On the
substrate- and stereospecificity of the plant
carotenoid cleavage dioxygenase 7. FEBS Lett
588(9):1802–1807.
https://doi.org/10.
1016/j.febslet.2014.03.041S0014-5793(14)
00260-9. [pii]
25. Frusciante S, Diretto G, Bruno M, Ferrante P,
Pietrella M, Prado-Cabrero A, Rubio-MoragaA, Beyer P, Gomez-Gomez L, Al-Babili S, Giuliano G (2014) Novel carotenoid cleavage
dioxygenase catalyzes the first dedicated step
in saffron crocin biosynthesis. Proc Natl Acad
Sci U S A 111(33):12246–12251. https://doi.
org/10.1073/pnas.
14046291111404629111. [pii]
26. Rodrigo MJ, Alquezar B, Alos E, Medina V,
Carmona L, Bruno M, Al-Babili S, Zacarias L
(2013) A novel carotenoid cleavage activity
involved in the biosynthesis of Citrus fruitspecific apocarotenoid pigments. J Exp Bot 64
(14):4461–4478. ert260 [pii]. https://doi.
org/10.1093/jxb/ert260
27. Ahrazem O, Diretto G, Argandona J, RubioMoraga A, Julve JM, Orzaez D, Granell A,
Gomez-Gomez L (2017) Evolutionarily distinct carotenoid cleavage dioxygenases are
responsible for crocetin production in Buddleja
davidii. J Exp Bot 68(16):4663–4677. https://
doi.org/10.1093/jxb/erx2774068697. [pii]
28. Auldridge ME, McCarty DR, Klee HJ (2006)
Plant carotenoid cleavage oxygenases and their
apocarotenoid products. Curr Opin Plant Biol
9(3):315–321..
S1369-5266(06)00044-6.
https://doi.org/10.1016/j.pbi.2006.03.005
29. Rodriguez-Concepcion M, Avalos J, Bonet
ML, Boronat A, Gomez-Gomez L, HorneroMendez D, Limon MC, Melendez-Martinez
AJ, Olmedilla-Alonso B, Palou A, Ribot J,
Rodrigo MJ, Zacarias L, Zhu C (2018) A
global perspective on carotenoids: metabolism,
biotechnology, and benefits for nutrition and
health. Prog Lipid Res 70:62–93. S0163-7827
(17)30039-5.
https://doi.org/10.1016/j.
plipres.2018.04.004
30. Auldridge ME, Block A, Vogel JT, DabneySmith C, Mila I, Bouzayen M, MagallanesLundback M, DellaPenna D, McCarty DR,
Klee HJ (2006) Characterization of three
members of the Arabidopsis carotenoid cleavage dioxygenase family demonstrates the divergent roles of this multifunctional enzyme
family. Plant J 45(6):982–993. TPJ2666 [pii].
https://doi.org/10.1111/j.1365-313X.
2006.02666.x
72
Lourdes Go ´ mez-Go ´ mez et al.