20. Ventura LL, Fortes NC, Santiago HC, Caliari
MV, Gomes MA, Oliveira DR (2017) Obesityinduced diet leads to weight gain, systemic
metabolic alterations, adipose tissue inflammation, hepatic steatosis, and oxidative stress in
gerbils. PeerJ 5:e2967. https://doi.org/10.
7717/peerj.2967
21. Mustonen AM, Puukka M, Rouvinen-Watt K,
Aho J, Asikainen J, Nieminen P (2009)
Response to fasting in an unnaturally obese
carnivore, the captive European polecat Mustela putorius. Exp Biol Med (Maywood) 234
(11):1287–1295. https://doi.org/10.3181/
0904-RM-140
22. Hinney A, Vogel CI, Hebebrand J (2010)
From monogenic to polygenic obesity: recent
advances. Eur Child Adolesc Psychiatry 19
(3):297–310.
https://doi.org/10.1007/
s00787-010-0096-6
23. Rosini TC, Silva AS (1992) Moraes C (2012)
diet-induced obesity: rodent model for the
study of obesity-related disorders. Rev Assoc
Med Bras 58(3):383–387
24. Petrov PD, Ribot J, Palou A, Bonet ML (2015)
Improved metabolic regulation is associated
with retinoblastoma protein gene haploinsufficiency in mice. Am J Physiol Endocrinol Metab
308(2):E172–E183.
https://doi.org/10.
1152/ajpendo.00308.2014
25. Marquardt N, Feja M, Hu ¨nigen H, Plendl J,
Menken L, Fink H, Bert B (2018) Euthanasia
of laboratory mice: are isoflurane and sevoflurane real alternatives to carbon dioxide? PLoS
One 13(9):e0203793. https://doi.org/10.
1371/journal.pone.0203793
26. Reyne ´s B, Serrano A, Petrov PD, Ribot J,
Chetrit C, Martı ´nez-Puig D, Bonet ML,
Palou A (2016) Anti-obesity and insulinsensitising effects of a glycosaminoglycan mix.
J Funct Foods 26:350–362. https://doi.org/
10.1016/j.jff.2016.07.022
27. Rodriguez E, Ribot J, Rodriguez AM, Palou A
(2004) PPAR-gamma 2 expression in response
to cafeteria diet: gender- and depot-specific
effects. Obes Res 12(9):1455–1463. https://
doi.org/10.1038/oby.2004.182
28. Ribot J, Rodrı ´guez AM, Rodrı ´guez E, Palou A
(2008) Adiponectin and resistin response in
the onset of obesity in male and female rats.
Obesity (Silver Spring) 16(4):723–730.
https://doi.org/10.1038/oby.2008.113
29. Reyne ´s B, Garcı ´a-Ruiz E, Dı ´az-Ru ´ a R, Palou A,
Oliver P (2014) Reversion to a control balanced diet is able to restore body weight and
to recover altered metabolic parameters in
adult rats long-term fed on a cafeteria diet.
Food Res Int 64:839–848. https://doi.org/
10.1016/j.foodres.2014.08.012
30. Sato Mito N, Suzui M, Yoshino H, Kaburagi T,
Sato K (2009) Long term effects of high fat
and sucrose diets on obesity and lymphocyte
proliferation in mice. J Nutr Health Aging 13
(7):602–606
31. Surwit RS, Feinglos MN, Rodin J,
Sutherland A, Petro AE, Opara EC, Kuhn
CM, Rebuffe ´-Scrive M (1995) Differential
effects of fat and sucrose on the development
of obesity and diabetes in C57BL/6J and a/J
mice. Metabolism 44(5):645–651
32. Buettner R, Scho ¨lmerich J, Bollheimer LC
(2007) High-fat diets: modeling the metabolic
disorders of human obesity in rodents. Obesity
(Silver Spring) 15(4):798–808. https://doi.
org/10.1038/oby.2007.608
33. Krishnan S, Cooper JA (2014) Effect of dietary
fatty acid composition on substrate utilization
and body weight maintenance in humans. Eur J
Nutr 53(3):691–710. https://doi.org/10.
1007/s00394-013-0638-z
34. Voigt A, Ribot J, Sabater AG, Palou A, Bonet
ML, Klaus S (2015) Identification of Mest/
Peg1 gene expression as a predictive biomarker
of adipose tissue expansion sensitive to dietary
anti-obesity interventions. Genes Nutr 10
(5):477. https://doi.org/10.1007/s12263015-0477-z
35. Voigt A, Agnew K, van Schothorst EM,
Keijer J, Klaus S (2013) Short-term, high fat
feeding-induced changes in white adipose tissue gene expression are highly predictive for
long-term changes. Mol Nutr Food Res 57
(8):1423–1434. https://doi.org/10.1002/
mnfr.201200671
36. Margareto J, Go ´ mez-Ambrosi J, Marti A, Martı ´nez JA (2001) Time-dependent effects of a
high-energy-yielding diet on the regulation of
specific white adipose tissue genes. Biochem
Biophys Res Commun 283(1):6–11. https://
doi.org/10.1006/bbrc.2001.4733
37. Ciapaite J, van den Broek NM, Te Brinke H,
Nicolay K, Jeneson JA, Houten SM, Prompers
JJ (2011) Differential effects of short- and
long-term high-fat diet feeding on hepatic
fatty acid metabolism in rats. Biochim Biophys
Acta 1811(7–8):441–451. https://doi.org/
10.1016/j.bbalip.2011.05.005
38. Li CC, Liu C, Fu M, Hu KQ, Aizawa K,
Takahashi S, Hiroyuki S, Cheng J, von
Lintig J, Wang XD (2018) Tomato powder
inhibits hepatic Steatosis and inflammation
potentially through restoring SIRT1 activity
and Adiponectin function independent of
carotenoid cleavage enzymes in mice. Mol
Nutr Food Res 62(8):e1700738. doi:https://
doi.org/10.1002/mnfr.201700738
416
Joan Ribot et al.
MV, Gomes MA, Oliveira DR (2017) Obesityinduced diet leads to weight gain, systemic
metabolic alterations, adipose tissue inflammation, hepatic steatosis, and oxidative stress in
gerbils. PeerJ 5:e2967. https://doi.org/10.
7717/peerj.2967
21. Mustonen AM, Puukka M, Rouvinen-Watt K,
Aho J, Asikainen J, Nieminen P (2009)
Response to fasting in an unnaturally obese
carnivore, the captive European polecat Mustela putorius. Exp Biol Med (Maywood) 234
(11):1287–1295. https://doi.org/10.3181/
0904-RM-140
22. Hinney A, Vogel CI, Hebebrand J (2010)
From monogenic to polygenic obesity: recent
advances. Eur Child Adolesc Psychiatry 19
(3):297–310.
https://doi.org/10.1007/
s00787-010-0096-6
23. Rosini TC, Silva AS (1992) Moraes C (2012)
diet-induced obesity: rodent model for the
study of obesity-related disorders. Rev Assoc
Med Bras 58(3):383–387
24. Petrov PD, Ribot J, Palou A, Bonet ML (2015)
Improved metabolic regulation is associated
with retinoblastoma protein gene haploinsufficiency in mice. Am J Physiol Endocrinol Metab
308(2):E172–E183.
https://doi.org/10.
1152/ajpendo.00308.2014
25. Marquardt N, Feja M, Hu ¨nigen H, Plendl J,
Menken L, Fink H, Bert B (2018) Euthanasia
of laboratory mice: are isoflurane and sevoflurane real alternatives to carbon dioxide? PLoS
One 13(9):e0203793. https://doi.org/10.
1371/journal.pone.0203793
26. Reyne ´s B, Serrano A, Petrov PD, Ribot J,
Chetrit C, Martı ´nez-Puig D, Bonet ML,
Palou A (2016) Anti-obesity and insulinsensitising effects of a glycosaminoglycan mix.
J Funct Foods 26:350–362. https://doi.org/
10.1016/j.jff.2016.07.022
27. Rodriguez E, Ribot J, Rodriguez AM, Palou A
(2004) PPAR-gamma 2 expression in response
to cafeteria diet: gender- and depot-specific
effects. Obes Res 12(9):1455–1463. https://
doi.org/10.1038/oby.2004.182
28. Ribot J, Rodrı ´guez AM, Rodrı ´guez E, Palou A
(2008) Adiponectin and resistin response in
the onset of obesity in male and female rats.
Obesity (Silver Spring) 16(4):723–730.
https://doi.org/10.1038/oby.2008.113
29. Reyne ´s B, Garcı ´a-Ruiz E, Dı ´az-Ru ´ a R, Palou A,
Oliver P (2014) Reversion to a control balanced diet is able to restore body weight and
to recover altered metabolic parameters in
adult rats long-term fed on a cafeteria diet.
Food Res Int 64:839–848. https://doi.org/
10.1016/j.foodres.2014.08.012
30. Sato Mito N, Suzui M, Yoshino H, Kaburagi T,
Sato K (2009) Long term effects of high fat
and sucrose diets on obesity and lymphocyte
proliferation in mice. J Nutr Health Aging 13
(7):602–606
31. Surwit RS, Feinglos MN, Rodin J,
Sutherland A, Petro AE, Opara EC, Kuhn
CM, Rebuffe ´-Scrive M (1995) Differential
effects of fat and sucrose on the development
of obesity and diabetes in C57BL/6J and a/J
mice. Metabolism 44(5):645–651
32. Buettner R, Scho ¨lmerich J, Bollheimer LC
(2007) High-fat diets: modeling the metabolic
disorders of human obesity in rodents. Obesity
(Silver Spring) 15(4):798–808. https://doi.
org/10.1038/oby.2007.608
33. Krishnan S, Cooper JA (2014) Effect of dietary
fatty acid composition on substrate utilization
and body weight maintenance in humans. Eur J
Nutr 53(3):691–710. https://doi.org/10.
1007/s00394-013-0638-z
34. Voigt A, Ribot J, Sabater AG, Palou A, Bonet
ML, Klaus S (2015) Identification of Mest/
Peg1 gene expression as a predictive biomarker
of adipose tissue expansion sensitive to dietary
anti-obesity interventions. Genes Nutr 10
(5):477. https://doi.org/10.1007/s12263015-0477-z
35. Voigt A, Agnew K, van Schothorst EM,
Keijer J, Klaus S (2013) Short-term, high fat
feeding-induced changes in white adipose tissue gene expression are highly predictive for
long-term changes. Mol Nutr Food Res 57
(8):1423–1434. https://doi.org/10.1002/
mnfr.201200671
36. Margareto J, Go ´ mez-Ambrosi J, Marti A, Martı ´nez JA (2001) Time-dependent effects of a
high-energy-yielding diet on the regulation of
specific white adipose tissue genes. Biochem
Biophys Res Commun 283(1):6–11. https://
doi.org/10.1006/bbrc.2001.4733
37. Ciapaite J, van den Broek NM, Te Brinke H,
Nicolay K, Jeneson JA, Houten SM, Prompers
JJ (2011) Differential effects of short- and
long-term high-fat diet feeding on hepatic
fatty acid metabolism in rats. Biochim Biophys
Acta 1811(7–8):441–451. https://doi.org/
10.1016/j.bbalip.2011.05.005
38. Li CC, Liu C, Fu M, Hu KQ, Aizawa K,
Takahashi S, Hiroyuki S, Cheng J, von
Lintig J, Wang XD (2018) Tomato powder
inhibits hepatic Steatosis and inflammation
potentially through restoring SIRT1 activity
and Adiponectin function independent of
carotenoid cleavage enzymes in mice. Mol
Nutr Food Res 62(8):e1700738. doi:https://
doi.org/10.1002/mnfr.201700738
416
Joan Ribot et al.