References
1. Palou A, Pico ´ C, Bonet ML (2003) The molecular basis of body weight control. Forum Nutr
56:164–168
2. Scully T (2014) Public health: society at large.
Nature 508(7496):S50–S51. https://doi.org/
10.1038/508S50a
3. Shao A, Drewnowski A, Willcox DC,
Kr€ amer L, Lausted C, Eggersdorfer M,
Mathers J, Bell JD, Randolph RK,
Witkamp R, Griffiths JC (2017) Optimal nutrition and the ever-changing dietary landscape: a
conference report. Eur J Nutr 56(Suppl
1):1–21. https://doi.org/10.1007/s00394017-1460-9
4. Vasileva LV, Marchev AS, Georgiev MI (2018)
Causes and solutions to “globesity”: the new fa
(s)t alarming global epidemic. Food Chem
Toxicol 121:173–193. https://doi.org/10.
1016/j.fct.2018.08.071
5. Lumeng CN, Saltiel AR (2011) Inflammatory
links between obesity and metabolic disease. J
Clin Invest 121(6):2111–2117. https://doi.
org/10.1172/JCI57132
6. Isolauri E (2017) Microbiota and obesity. Nestle Nutr Inst Workshop Ser 88:95–105.
https://doi.org/10.1159/000455217
7. Bonet ML, Canas JA, Ribot J, Palou A (2015)
Carotenoids and their conversion products in
the control of adipocyte function, adiposity
and obesity. Arch Biochem Biophys
572:112–125.
https://doi.org/10.1016/j.
abb.2015.02.022
8. Bonet ML, Canas JA, Ribot J, Palou A (2016)
Carotenoids in adipose tissue biology and obesity. Subcell Biochem 79:377–414. https://
doi.org/10.1007/978-3-319-39126-7_15
9. Rodriguez-Concepcion M, Avalos J, Bonet
ML, Boronat A, Gomez-Gomez L, HorneroMendez D, Limon MC, Mele ´ndez-Martı ´nez
AJ, Olmedilla-Alonso B, Palou A, Ribot J,
Rodrigo MJ, Zacarias L, Zhu C (2018) A
global perspective on carotenoids: metabolism,
biotechnology, and benefits for nutrition and
health. Prog Lipid Res 70:62–93. https://doi.
org/10.1016/j.plipres.2018.04.004
10. Lee CM, Boileau AC, Boileau TW, Williams
AW, Swanson KS, Heintz KA, Erdman JW
(1999) Review of animal models in carotenoid
research. J Nutr 129(12):2271–2277. https://
doi.org/10.1093/jn/129.12.2271
11. Palczewski G, Widjaja-Adhi MA, Amengual J,
Golczak M, von Lintig J (2016) Genetic dissection in a mouse model reveals interactions
between carotenoids and lipid metabolism. J
Lipid Res 57(9):1684–1695. https://doi.
org/10.1194/jlr.M069021
12. Amengual J, Gouranton E, van Helden YG,
Hessel S, Ribot J, Kramer E, Kiec-Wilk B,
Razny U, Lietz G, Wyss A, DembinskaKiec A, Palou A, Keijer J, Landrier JF, Bonet
ML, von Lintig J (2011) Beta-carotene reduces
body adiposity of mice via BCMO1. PLoS One
6(6):e20644. https://doi.org/10.1371/jour
nal.pone.0020644
13. Musinovic H, Bonet ML, Granados N,
Amengual J, von Lintig J, Ribot J, Palou A
(2014) Beta-carotene during the suckling
period is absorbed intact and induces retinoic
acid dependent responses similar to preformed
vitamin a in intestine and liver, but not adipose
tissue of young rats. Mol Nutr Food Res
58 (11):2157–2165. doi:https://doi.org/10.
1002/mnfr.201400457
14. Granados N, Amengual J, Ribot J,
Musinovic H, Ceresi E, von Lintig J, Palou A,
Bonet ML (2013) Vitamin a supplementation
in early life affects later response to an obesogenic diet in rats. Int J Obes 37
(9):1169–1176. https://doi.org/10.1038/
ijo.2012.190
15. Arreguı ´n A, Ribot J, Mus ˇinovic ´ H, von
Lintig J, Palou A, Bonet ML (2018) Dietary
vitamin a impacts DNA methylation patterns of
adipogenesis-related genes in suckling rats.
Arch Biochem Biophys 650:75–84. https://
doi.org/10.1016/j.abb.2018.05.009
16. Nilsson C, Raun K, Yan FF, Larsen MO, TangChristensen M (2012) Laboratory animals as
surrogate models of human obesity. Acta Pharmacol Sin 33(2):173–181. https://doi.org/
10.1038/aps.2011.203
17. Panchal SK, Poudyal H, Iyer A, Nazer R, Alam
MA, Diwan V, Kauter K, Sernia C, Campbell F,
Ward L, Gobe G, Fenning A, Brown L (2011)
High-carbohydrate, high-fat diet-induced
metabolic syndrome and cardiovascular remodeling in rats. J Cardiovasc Pharmacol 57
(5):611–624. https://doi.org/10.1097/FJC.
0b013e31821b1379
18. Panchal SK, Brown L (2011) Rodent models
for metabolic syndrome research. J Biomed
Biotechnol 2011:351982. https://doi.org/
10.1155/2011/351982
19. Lai M, Chandrasekera PC, Barnard ND (2014)
You are what you eat, or are you? The challenges of translating high-fat-fed rodents to
human obesity and diabetes. Nutr Diabetes 4:
e135. https://doi.org/10.1038/nutd.2014.
30
Mouse Models to Study Antiobesogenic Effects of Carotenoids
415
1. Palou A, Pico ´ C, Bonet ML (2003) The molecular basis of body weight control. Forum Nutr
56:164–168
2. Scully T (2014) Public health: society at large.
Nature 508(7496):S50–S51. https://doi.org/
10.1038/508S50a
3. Shao A, Drewnowski A, Willcox DC,
Kr€ amer L, Lausted C, Eggersdorfer M,
Mathers J, Bell JD, Randolph RK,
Witkamp R, Griffiths JC (2017) Optimal nutrition and the ever-changing dietary landscape: a
conference report. Eur J Nutr 56(Suppl
1):1–21. https://doi.org/10.1007/s00394017-1460-9
4. Vasileva LV, Marchev AS, Georgiev MI (2018)
Causes and solutions to “globesity”: the new fa
(s)t alarming global epidemic. Food Chem
Toxicol 121:173–193. https://doi.org/10.
1016/j.fct.2018.08.071
5. Lumeng CN, Saltiel AR (2011) Inflammatory
links between obesity and metabolic disease. J
Clin Invest 121(6):2111–2117. https://doi.
org/10.1172/JCI57132
6. Isolauri E (2017) Microbiota and obesity. Nestle Nutr Inst Workshop Ser 88:95–105.
https://doi.org/10.1159/000455217
7. Bonet ML, Canas JA, Ribot J, Palou A (2015)
Carotenoids and their conversion products in
the control of adipocyte function, adiposity
and obesity. Arch Biochem Biophys
572:112–125.
https://doi.org/10.1016/j.
abb.2015.02.022
8. Bonet ML, Canas JA, Ribot J, Palou A (2016)
Carotenoids in adipose tissue biology and obesity. Subcell Biochem 79:377–414. https://
doi.org/10.1007/978-3-319-39126-7_15
9. Rodriguez-Concepcion M, Avalos J, Bonet
ML, Boronat A, Gomez-Gomez L, HorneroMendez D, Limon MC, Mele ´ndez-Martı ´nez
AJ, Olmedilla-Alonso B, Palou A, Ribot J,
Rodrigo MJ, Zacarias L, Zhu C (2018) A
global perspective on carotenoids: metabolism,
biotechnology, and benefits for nutrition and
health. Prog Lipid Res 70:62–93. https://doi.
org/10.1016/j.plipres.2018.04.004
10. Lee CM, Boileau AC, Boileau TW, Williams
AW, Swanson KS, Heintz KA, Erdman JW
(1999) Review of animal models in carotenoid
research. J Nutr 129(12):2271–2277. https://
doi.org/10.1093/jn/129.12.2271
11. Palczewski G, Widjaja-Adhi MA, Amengual J,
Golczak M, von Lintig J (2016) Genetic dissection in a mouse model reveals interactions
between carotenoids and lipid metabolism. J
Lipid Res 57(9):1684–1695. https://doi.
org/10.1194/jlr.M069021
12. Amengual J, Gouranton E, van Helden YG,
Hessel S, Ribot J, Kramer E, Kiec-Wilk B,
Razny U, Lietz G, Wyss A, DembinskaKiec A, Palou A, Keijer J, Landrier JF, Bonet
ML, von Lintig J (2011) Beta-carotene reduces
body adiposity of mice via BCMO1. PLoS One
6(6):e20644. https://doi.org/10.1371/jour
nal.pone.0020644
13. Musinovic H, Bonet ML, Granados N,
Amengual J, von Lintig J, Ribot J, Palou A
(2014) Beta-carotene during the suckling
period is absorbed intact and induces retinoic
acid dependent responses similar to preformed
vitamin a in intestine and liver, but not adipose
tissue of young rats. Mol Nutr Food Res
58 (11):2157–2165. doi:https://doi.org/10.
1002/mnfr.201400457
14. Granados N, Amengual J, Ribot J,
Musinovic H, Ceresi E, von Lintig J, Palou A,
Bonet ML (2013) Vitamin a supplementation
in early life affects later response to an obesogenic diet in rats. Int J Obes 37
(9):1169–1176. https://doi.org/10.1038/
ijo.2012.190
15. Arreguı ´n A, Ribot J, Mus ˇinovic ´ H, von
Lintig J, Palou A, Bonet ML (2018) Dietary
vitamin a impacts DNA methylation patterns of
adipogenesis-related genes in suckling rats.
Arch Biochem Biophys 650:75–84. https://
doi.org/10.1016/j.abb.2018.05.009
16. Nilsson C, Raun K, Yan FF, Larsen MO, TangChristensen M (2012) Laboratory animals as
surrogate models of human obesity. Acta Pharmacol Sin 33(2):173–181. https://doi.org/
10.1038/aps.2011.203
17. Panchal SK, Poudyal H, Iyer A, Nazer R, Alam
MA, Diwan V, Kauter K, Sernia C, Campbell F,
Ward L, Gobe G, Fenning A, Brown L (2011)
High-carbohydrate, high-fat diet-induced
metabolic syndrome and cardiovascular remodeling in rats. J Cardiovasc Pharmacol 57
(5):611–624. https://doi.org/10.1097/FJC.
0b013e31821b1379
18. Panchal SK, Brown L (2011) Rodent models
for metabolic syndrome research. J Biomed
Biotechnol 2011:351982. https://doi.org/
10.1155/2011/351982
19. Lai M, Chandrasekera PC, Barnard ND (2014)
You are what you eat, or are you? The challenges of translating high-fat-fed rodents to
human obesity and diabetes. Nutr Diabetes 4:
e135. https://doi.org/10.1038/nutd.2014.
30
Mouse Models to Study Antiobesogenic Effects of Carotenoids
415