1 3
Topics in Current Chemistry (2018) 376:46
This continuous flow system achieved a TON of 66 with an approximately tenfold
increase with respect to batch conditions (Scheme 2).
Fluorinated organocatalyst 3b, supported by a co-polymerization reaction to a
polystyrene network, was found effective in Michael reactions, and for the preparation of a small library of chiral γ-nitroaldehydes 5a–m [36]. This supported catalyst was found very robust, and durable if preserved by air and maintained under
precise storing conditions. The catalyst was tested in a packed-bed flow reactor in
the synthesis of adduct 5m (Scheme 3). The flow system could be run for 13 h at
a flow rate of 100 μl/min observing only a slight decrease in conversion (always
above 97%) and without affecting stereoselectivity (er: 98:2). Michael adduct 5m
Scheme 3 Use of supported fluorinated proline-like catalysts for continuous flow production of
γ-nitroaldehydes
33
Reprinted from the journal
Topics in Current Chemistry (2018) 376:46
This continuous flow system achieved a TON of 66 with an approximately tenfold
increase with respect to batch conditions (Scheme 2).
Fluorinated organocatalyst 3b, supported by a co-polymerization reaction to a
polystyrene network, was found effective in Michael reactions, and for the preparation of a small library of chiral γ-nitroaldehydes 5a–m [36]. This supported catalyst was found very robust, and durable if preserved by air and maintained under
precise storing conditions. The catalyst was tested in a packed-bed flow reactor in
the synthesis of adduct 5m (Scheme 3). The flow system could be run for 13 h at
a flow rate of 100 μl/min observing only a slight decrease in conversion (always
above 97%) and without affecting stereoselectivity (er: 98:2). Michael adduct 5m
Scheme 3 Use of supported fluorinated proline-like catalysts for continuous flow production of
γ-nitroaldehydes
33
Reprinted from the journal