Topics in Current Chemistry (2019) 377:2
1 3
38. Erdmann N, Su Y, Bosmans B, Hessel V, Noel T (2016) Palladium‑catalyzed aerobic oxidative
coupling of O‑xylene in flow: a safe and scalable protocol for cross‑dehydrogenative coupling. Org
Process Res Dev 20:831–835
39. Izawa Y, Stahl SS (2010) Aerobic oxidative coupling of o‑xylene: discovery of 2‑fluoropyridine as
a ligand to support selective Pd‑catalyzed. Adv Synth Catal 352:3223–3229
40. Gemoets HPL, Hessel V, Noël T (2014) Aerobic C–H olefination of indoles via a cross‑dehydro‑
genative coupling in continuous flow. Org Lett 16:5800–5803
41. Hone CA, Lopatka P, Munday R, O’Kearney‑McMullan A, Kappe CO (2018) Continuous‑flow
synthesis of aryl aldehydes by Pd‑catalyzed formylation of aryl bromides using carbon monoxide
and hydrogen. ChemSusChem. https ://doi.org/10.1002/cssc.20180 2261
42. Chen Y, Hone CA, Gutmann B, Kappe CO (2017) Continuous flow synthesis of carbonylated het‑
erocycles via Pd‑catalyzed oxidative carbonylation using CO and O 2 at elevated temperature and
pressure. Org Process Res Dev 21:1080–1087
43. Wendlandt AE, Suess AM, Stahl SS (2011) Copper‑catalyzed aerobic oxidative C–H functionaliza‑
tions: trends and mechanistic insights. Angew Chem Int Ed 50:11062–11087
44. Greene JF, Hoover JM, Mannel DS, Root TW, Stahl SS (2013) Continuous‑flow aerobic oxida‑
tion of primary alcohols with a copper(I)/TEMPO catalyst. Org Process Res Dev 17:1247–1251
45. Vanoye L, Pablos M, De Bellefon C, Favre‑Réguillon A (2015) Gas‑liquid segmented flow
microfluidics for screening copper/tempo‑catalyzed aerobic oxidation of primary alcohols. Adv
Synth Catal 357:739–746
46. Gutmann B, Elsner P, Roberge D, Kappe CO (2013) Homogeneous liquid‑phase oxidation of
ethylbenzene to acetophenone in continuous flow mode. ACS Catal 3:2669–2676
47. Pieber B, Kappe CO (2013) Direct aerobic oxidation of 2‑benzylpyridines in a gas–liquid con‑
tinuous‑flow regime using propylene carbonate as a solvent. Green Chem 15:320–324
48. Vanoye L, Aloui A, Pablos M, Philippe R, Percheron A, Favre‑Réguillon A, De Bellefon C
(2013) A safe and efficient flow oxidation of aldehydes with O 2 . Org Lett 15:5978–5981
49. Vanoye L, Pablos M, Smith N, De Bellefon C, Favre‑Réguillon A (2014) Aerobic oxidation of
aldehydes: selectivity improvement using sequential pulse experimentation in continuous flow
microreactor. RSC Adv 4:57159–57163
50. Vanoye L, Wang J, Pablos M, De Bellefon C, Favre‑Réguillon A (2016) Continuous, fast, and
safe aerobic oxidation of 2‑ethylhexanal: pushing the limits of the simple tube reactor for a gas/
liquid reaction. Org Process Res Dev 20:90–94
51. Vanoye L, Wang J, Pablos M, de Bellefon C, Favre‑Réguillon A (2016) Epoxidation using
molecular oxygen in flow: facts and questions on the mechanism of the Mukaiyama epoxida‑
tion. Catal Sci Technol 6:4724–4732
52. Guo S, Yu Z, Yu C (2018) Kilogram‑scale synthesis of 2,4‑dichloro‑5‑fluorobenzoic acid by air
oxidation under the continuous‑flow process. Org Process Res Dev 22:252–256
53. Munirathinam R, Huskens J, Verboom W (2015) Supported catalysis in continuous‑flow micro‑
reactors. Adv Synth Catal 357:1093–1123
54. Campanati M, Fornasari G, Vaccari A (2003) Fundamentals in the preparation of heterogeneous
catalysts. Catal Today 77:299–314
55. Cantillo D, Kappe CO (2015) Immobilized transition metals as catalysts for cross‑couplings in
continuous flow—a critical assessment of the reaction mechanism and metal leaching. Chem‑
CatChem 6:3286–3305
56. Parmeggiani C, Matassini C, Cardona F (2017) A step forward towards sustainable aerobic
alcohol oxidation: new and revised catalysts based on transition metals on solid supports. Green
Chem 19:2030–2050
57. Zotova N, Hellgardt K, Kelsall GH, Jessiman AS, Hii KKM (2010) Catalysis in flow: the
practical and selective aerobic oxidation of alcohols to aldehydes and ketones. Green Chem
12:2157–2163
58. Mannel DS, Stahl SS, Root TW (2014) Continuous flow aerobic alcohol oxidation reactions
using a heterogeneous Ru(OH)x/Al 2 O 3 catalyst. Org Process Res Dev 18:1503–1508
59. Obermayer D, Balu AM, Romero AA, Goessler W, Luque R, Kappe CO (2013) Nanocatalysis
in continuous flow: supported iron oxide nanoparticles for the heterogeneous aerobic oxidation
of benzyl alcohol. Green Chem 15:1530–1537
60. Liu X, Ünal B, Jensen KF (2012) Heterogeneous catalysis with continuous flow microreactors.
Catal Sci Technol 2:2134–2138
106
Reprinted from the journal
1 3
38. Erdmann N, Su Y, Bosmans B, Hessel V, Noel T (2016) Palladium‑catalyzed aerobic oxidative
coupling of O‑xylene in flow: a safe and scalable protocol for cross‑dehydrogenative coupling. Org
Process Res Dev 20:831–835
39. Izawa Y, Stahl SS (2010) Aerobic oxidative coupling of o‑xylene: discovery of 2‑fluoropyridine as
a ligand to support selective Pd‑catalyzed. Adv Synth Catal 352:3223–3229
40. Gemoets HPL, Hessel V, Noël T (2014) Aerobic C–H olefination of indoles via a cross‑dehydro‑
genative coupling in continuous flow. Org Lett 16:5800–5803
41. Hone CA, Lopatka P, Munday R, O’Kearney‑McMullan A, Kappe CO (2018) Continuous‑flow
synthesis of aryl aldehydes by Pd‑catalyzed formylation of aryl bromides using carbon monoxide
and hydrogen. ChemSusChem. https ://doi.org/10.1002/cssc.20180 2261
42. Chen Y, Hone CA, Gutmann B, Kappe CO (2017) Continuous flow synthesis of carbonylated het‑
erocycles via Pd‑catalyzed oxidative carbonylation using CO and O 2 at elevated temperature and
pressure. Org Process Res Dev 21:1080–1087
43. Wendlandt AE, Suess AM, Stahl SS (2011) Copper‑catalyzed aerobic oxidative C–H functionaliza‑
tions: trends and mechanistic insights. Angew Chem Int Ed 50:11062–11087
44. Greene JF, Hoover JM, Mannel DS, Root TW, Stahl SS (2013) Continuous‑flow aerobic oxida‑
tion of primary alcohols with a copper(I)/TEMPO catalyst. Org Process Res Dev 17:1247–1251
45. Vanoye L, Pablos M, De Bellefon C, Favre‑Réguillon A (2015) Gas‑liquid segmented flow
microfluidics for screening copper/tempo‑catalyzed aerobic oxidation of primary alcohols. Adv
Synth Catal 357:739–746
46. Gutmann B, Elsner P, Roberge D, Kappe CO (2013) Homogeneous liquid‑phase oxidation of
ethylbenzene to acetophenone in continuous flow mode. ACS Catal 3:2669–2676
47. Pieber B, Kappe CO (2013) Direct aerobic oxidation of 2‑benzylpyridines in a gas–liquid con‑
tinuous‑flow regime using propylene carbonate as a solvent. Green Chem 15:320–324
48. Vanoye L, Aloui A, Pablos M, Philippe R, Percheron A, Favre‑Réguillon A, De Bellefon C
(2013) A safe and efficient flow oxidation of aldehydes with O 2 . Org Lett 15:5978–5981
49. Vanoye L, Pablos M, Smith N, De Bellefon C, Favre‑Réguillon A (2014) Aerobic oxidation of
aldehydes: selectivity improvement using sequential pulse experimentation in continuous flow
microreactor. RSC Adv 4:57159–57163
50. Vanoye L, Wang J, Pablos M, De Bellefon C, Favre‑Réguillon A (2016) Continuous, fast, and
safe aerobic oxidation of 2‑ethylhexanal: pushing the limits of the simple tube reactor for a gas/
liquid reaction. Org Process Res Dev 20:90–94
51. Vanoye L, Wang J, Pablos M, de Bellefon C, Favre‑Réguillon A (2016) Epoxidation using
molecular oxygen in flow: facts and questions on the mechanism of the Mukaiyama epoxida‑
tion. Catal Sci Technol 6:4724–4732
52. Guo S, Yu Z, Yu C (2018) Kilogram‑scale synthesis of 2,4‑dichloro‑5‑fluorobenzoic acid by air
oxidation under the continuous‑flow process. Org Process Res Dev 22:252–256
53. Munirathinam R, Huskens J, Verboom W (2015) Supported catalysis in continuous‑flow micro‑
reactors. Adv Synth Catal 357:1093–1123
54. Campanati M, Fornasari G, Vaccari A (2003) Fundamentals in the preparation of heterogeneous
catalysts. Catal Today 77:299–314
55. Cantillo D, Kappe CO (2015) Immobilized transition metals as catalysts for cross‑couplings in
continuous flow—a critical assessment of the reaction mechanism and metal leaching. Chem‑
CatChem 6:3286–3305
56. Parmeggiani C, Matassini C, Cardona F (2017) A step forward towards sustainable aerobic
alcohol oxidation: new and revised catalysts based on transition metals on solid supports. Green
Chem 19:2030–2050
57. Zotova N, Hellgardt K, Kelsall GH, Jessiman AS, Hii KKM (2010) Catalysis in flow: the
practical and selective aerobic oxidation of alcohols to aldehydes and ketones. Green Chem
12:2157–2163
58. Mannel DS, Stahl SS, Root TW (2014) Continuous flow aerobic alcohol oxidation reactions
using a heterogeneous Ru(OH)x/Al 2 O 3 catalyst. Org Process Res Dev 18:1503–1508
59. Obermayer D, Balu AM, Romero AA, Goessler W, Luque R, Kappe CO (2013) Nanocatalysis
in continuous flow: supported iron oxide nanoparticles for the heterogeneous aerobic oxidation
of benzyl alcohol. Green Chem 15:1530–1537
60. Liu X, Ünal B, Jensen KF (2012) Heterogeneous catalysis with continuous flow microreactors.
Catal Sci Technol 2:2134–2138
106
Reprinted from the journal