1 3
Topics in Current Chemistry (2019) 377:2
61. Durndell LJ, Cucuzzella C, Parlett CMA, Isaacs MA, Wilson K, Lee AF (2018) Platinum cata‑
lysed aerobic selective oxidation of cinnamaldehyde to cinnamic acid. Catal Today. https ://doi.
org/10.1016/j.catto d.2018.02.052
62. Wang N, Matsumoto T, Ueno M, Miyamura H, Kobayashi S (2009) A gold‑immobilized micro‑
channel flow reactor for oxidation of alcohols with molecular oxygen. Angew Chem Int Ed
48:4744–4746
63. Sankar M, Dimitratos N, Miedziak PJ, Wells PP, Kiely J, Hutchings GJ (2012) Designing bime‑
tallic catalysts for a green and sustainable future. Chem Soc Rev 41:8099–8139
64. Wu G, Brett GL, Cao E, Constantinou A, Ellis P, Kuhn S, Hutchings GJ, Bethell D, Gavriilidis
A (2016) Oxidation of cinnamyl alcohol using bimetallic Au–Pd/TiO 2 catalysts: a deactivation
study in a continuous flow packed bed microreactor. Catal Sci Technol 6:4749–4758
65. Mannel DS, Ahmed MS, Root TW, Stahl SS (2017) Discovery of multicomponent heterogene‑
ous catalysts via admixture screening: PdBiTe catalysts for aerobic oxidative esterification of
primary alcohols. J Am Chem Soc 139:1690–1698
66. Watson DJ, Dowdy ED, Depue JS, Kotnis AS, Leung S, Reilly BCO (2004) Development of a safe
and scalable oxidation process for the preparation of 6‑hydroxybuspirone: application of in‑line
monitoring for process ruggedness and product quality. Org Process Res Dev 8:616–623
67. Laporte TL, Hamedi M, Depue JS, Shen L, Watson D, Hsieh D (2008) Development and scale‑up
of three consecutive continuous reactions for production of 6‑hydroxybuspirone. Org Process Res
Dev 12:956–966
68. Pieber B, Martinez ST, Cantillo D, Kappe CO (2013) In situ generation of diimide from hydra‑
zine and oxygen: continuous‑flow transfer hydrogenation of olefins. Angew Chemie Int Ed
52:10241–10244
69. Feth MP, Rossen K, Burgard A (2013) Pilot plant PAT approach for the diastereoselective diimide
reduction of artemisinic acid. Org Process Res Dev 17:282–293
70. Pieber B, Glasnov T, Kappe CO (2015) Continuous flow reduction of artemisinic acid utilizing
multi‑injection strategies‑closing the gap towards a fully continuous synthesis of antimalarial
drugs. Chem Eur J 21:4368–4376
71. Pieber B, Cox DP, Kappe CO (2016) Selective olefin reduction in thebaine using hydrazine hydrate
and O 2 under intensified continuous flow conditions. Org Process Res Dev 20:376–385
72. He Z, Jamison TF (2014) Continuous‑flow synthesis of functionalized phenols by aerobic oxida‑
tion of Grignard reagents. Angew Chem Int Ed 53:3353–3357
73. De Angelis S, Hone CA, Degennaro L, Celestini P, Luisi R, Kappe CO (2018) Sequential
α‑lithiation and aerobic oxidation of an arylacetic acid—continuous‑flow synthesis of cyclopentyl
mandelic acid. J Flow Chem 8:109–116
74. Noël T, Hessel V (2013) Membrane microreactors: gas–liquid reactions made easy. ChemSusChem
6:405–407
75. Brzozowski M, O’Brien M, Ley SV, Polyzos A (2015) Flow chemistry: intelligent processing of
gas–liquid transformations using a tube‑in‑tube reactor. Acc Chem Res 48:349–362
76. Bourne SL, Ley SV (2013) A continuous flow solution to achieving efficient aerobic anti‑Marko‑
vnikov Wacker oxidation. Adv Synth Catal 355:1905–1910
77. Petersen TP, Polyzos A, Brien MO, Ulven T, Baxendale IR, Ley SV (2012) The oxygen‑mediated
synthesis of 1,3‑butadiynes in continuous flow: using teflon AF‑2400 to effect gas/liquid contact.
ChemSusChem 5:274–277
78. Brzozowski M, Forni JA, Savage PG, Polyzos A (2015) The direct α‑C(sp3)‑H functionalisation of
N‑aryl tetrahydroisoquinolines via an iron‑catalysed aerobic nitro‑Mannich reaction and continu‑
ous flow processing. Chem Commun 51:334–337
79. Chaudhuri SR, Hartwig J, Kupracz L, Kodanek T, Wegner J, Kirschning A (2014) Oxida‑
tions of allylic and benzylic alcohols under inductively‑heated flow conditions with gold‑doped
superparamagnetic nanostructured particles as catalyst and oxygen as oxidant. Adv Synth Catal
356:3530–3538
80. Park JH, Park CY, Kim MJ, Kim MU, Kim YJ, Kim GH, Park CP (2015) Continuous‑flow synthe‑
sis of meta‑substituted phenol derivatives. Org Process Res Dev 19:812–818
81. Hollmann F, Arends IWCE, Buehler K, Bruno B (2011) Enzyme‑mediated oxidations for the
chemist. Green Chem 13:226–265
82. Ringborg RH, Toftgaard Pedersen A, Woodley JM (2017) Automated determination of oxygen‑
dependent enzyme kinetics in a tube‑in‑tube flow reactor. ChemCatChem 9:3273
107
Reprinted from the journal
Topics in Current Chemistry (2019) 377:2
61. Durndell LJ, Cucuzzella C, Parlett CMA, Isaacs MA, Wilson K, Lee AF (2018) Platinum cata‑
lysed aerobic selective oxidation of cinnamaldehyde to cinnamic acid. Catal Today. https ://doi.
org/10.1016/j.catto d.2018.02.052
62. Wang N, Matsumoto T, Ueno M, Miyamura H, Kobayashi S (2009) A gold‑immobilized micro‑
channel flow reactor for oxidation of alcohols with molecular oxygen. Angew Chem Int Ed
48:4744–4746
63. Sankar M, Dimitratos N, Miedziak PJ, Wells PP, Kiely J, Hutchings GJ (2012) Designing bime‑
tallic catalysts for a green and sustainable future. Chem Soc Rev 41:8099–8139
64. Wu G, Brett GL, Cao E, Constantinou A, Ellis P, Kuhn S, Hutchings GJ, Bethell D, Gavriilidis
A (2016) Oxidation of cinnamyl alcohol using bimetallic Au–Pd/TiO 2 catalysts: a deactivation
study in a continuous flow packed bed microreactor. Catal Sci Technol 6:4749–4758
65. Mannel DS, Ahmed MS, Root TW, Stahl SS (2017) Discovery of multicomponent heterogene‑
ous catalysts via admixture screening: PdBiTe catalysts for aerobic oxidative esterification of
primary alcohols. J Am Chem Soc 139:1690–1698
66. Watson DJ, Dowdy ED, Depue JS, Kotnis AS, Leung S, Reilly BCO (2004) Development of a safe
and scalable oxidation process for the preparation of 6‑hydroxybuspirone: application of in‑line
monitoring for process ruggedness and product quality. Org Process Res Dev 8:616–623
67. Laporte TL, Hamedi M, Depue JS, Shen L, Watson D, Hsieh D (2008) Development and scale‑up
of three consecutive continuous reactions for production of 6‑hydroxybuspirone. Org Process Res
Dev 12:956–966
68. Pieber B, Martinez ST, Cantillo D, Kappe CO (2013) In situ generation of diimide from hydra‑
zine and oxygen: continuous‑flow transfer hydrogenation of olefins. Angew Chemie Int Ed
52:10241–10244
69. Feth MP, Rossen K, Burgard A (2013) Pilot plant PAT approach for the diastereoselective diimide
reduction of artemisinic acid. Org Process Res Dev 17:282–293
70. Pieber B, Glasnov T, Kappe CO (2015) Continuous flow reduction of artemisinic acid utilizing
multi‑injection strategies‑closing the gap towards a fully continuous synthesis of antimalarial
drugs. Chem Eur J 21:4368–4376
71. Pieber B, Cox DP, Kappe CO (2016) Selective olefin reduction in thebaine using hydrazine hydrate
and O 2 under intensified continuous flow conditions. Org Process Res Dev 20:376–385
72. He Z, Jamison TF (2014) Continuous‑flow synthesis of functionalized phenols by aerobic oxida‑
tion of Grignard reagents. Angew Chem Int Ed 53:3353–3357
73. De Angelis S, Hone CA, Degennaro L, Celestini P, Luisi R, Kappe CO (2018) Sequential
α‑lithiation and aerobic oxidation of an arylacetic acid—continuous‑flow synthesis of cyclopentyl
mandelic acid. J Flow Chem 8:109–116
74. Noël T, Hessel V (2013) Membrane microreactors: gas–liquid reactions made easy. ChemSusChem
6:405–407
75. Brzozowski M, O’Brien M, Ley SV, Polyzos A (2015) Flow chemistry: intelligent processing of
gas–liquid transformations using a tube‑in‑tube reactor. Acc Chem Res 48:349–362
76. Bourne SL, Ley SV (2013) A continuous flow solution to achieving efficient aerobic anti‑Marko‑
vnikov Wacker oxidation. Adv Synth Catal 355:1905–1910
77. Petersen TP, Polyzos A, Brien MO, Ulven T, Baxendale IR, Ley SV (2012) The oxygen‑mediated
synthesis of 1,3‑butadiynes in continuous flow: using teflon AF‑2400 to effect gas/liquid contact.
ChemSusChem 5:274–277
78. Brzozowski M, Forni JA, Savage PG, Polyzos A (2015) The direct α‑C(sp3)‑H functionalisation of
N‑aryl tetrahydroisoquinolines via an iron‑catalysed aerobic nitro‑Mannich reaction and continu‑
ous flow processing. Chem Commun 51:334–337
79. Chaudhuri SR, Hartwig J, Kupracz L, Kodanek T, Wegner J, Kirschning A (2014) Oxida‑
tions of allylic and benzylic alcohols under inductively‑heated flow conditions with gold‑doped
superparamagnetic nanostructured particles as catalyst and oxygen as oxidant. Adv Synth Catal
356:3530–3538
80. Park JH, Park CY, Kim MJ, Kim MU, Kim YJ, Kim GH, Park CP (2015) Continuous‑flow synthe‑
sis of meta‑substituted phenol derivatives. Org Process Res Dev 19:812–818
81. Hollmann F, Arends IWCE, Buehler K, Bruno B (2011) Enzyme‑mediated oxidations for the
chemist. Green Chem 13:226–265
82. Ringborg RH, Toftgaard Pedersen A, Woodley JM (2017) Automated determination of oxygen‑
dependent enzyme kinetics in a tube‑in‑tube flow reactor. ChemCatChem 9:3273
107
Reprinted from the journal