Topics in Current Chemistry (2019) 377:35
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Lewis acid-mediated substrate organization of NHC-bound homoenolate and
an electrophile also enabled the enantioselective remote β-protonation of β,βdisubstituted enals. Chen’s group reported a chiral NHC/Cu synergistic catalysis
for enantioselective β-protonation of β,β-disubstituted enals with thiols (Fig. 11)
Fig. 9 NHC/chiral lithium phosphate cooperative catalysis
Fig. 10 NHC/Ca/HBD-catalyzed lactonization of enals with α-ketoesters
Fig. 11 Enantioselective β-protonation of enals by NHC/Cu cooperative catalysis
Reprinted from the journal
88
1 3
Lewis acid-mediated substrate organization of NHC-bound homoenolate and
an electrophile also enabled the enantioselective remote β-protonation of β,βdisubstituted enals. Chen’s group reported a chiral NHC/Cu synergistic catalysis
for enantioselective β-protonation of β,β-disubstituted enals with thiols (Fig. 11)
Fig. 9 NHC/chiral lithium phosphate cooperative catalysis
Fig. 10 NHC/Ca/HBD-catalyzed lactonization of enals with α-ketoesters
Fig. 11 Enantioselective β-protonation of enals by NHC/Cu cooperative catalysis
Reprinted from the journal
88