1 3
Topics in Current Chemistry (2019) 377:23
by changing the steric and electronic effect of the ligand. Three porous chiral
MOFs with the framework formula were prepared from different chiral CPA.
As shown in Scheme 3, under both batch and flow reaction conditions, the
CF 3 -containing MOF 12 from (R)-L3 displayed excellent reactivity in the enantioselective alkylations of indoles and pyrroles 9 with electron-poor alkenes 10.
In contrast, the corresponding homogeneous catalysts gave targets 11 with low
enantioselectivities.
Scheme 2 Asymmetric addition of β-dicarbonyls to ortho-quinone methides (o-QMs) via relay Mn(III)
phosphate catalysis
Scheme 3 Enantioselectivity of metal–organic frameworks (MOFs) for alkylation of indoles and pyrroles
Reprinted from the journal
157
Topics in Current Chemistry (2019) 377:23
by changing the steric and electronic effect of the ligand. Three porous chiral
MOFs with the framework formula were prepared from different chiral CPA.
As shown in Scheme 3, under both batch and flow reaction conditions, the
CF 3 -containing MOF 12 from (R)-L3 displayed excellent reactivity in the enantioselective alkylations of indoles and pyrroles 9 with electron-poor alkenes 10.
In contrast, the corresponding homogeneous catalysts gave targets 11 with low
enantioselectivities.
Scheme 2 Asymmetric addition of β-dicarbonyls to ortho-quinone methides (o-QMs) via relay Mn(III)
phosphate catalysis
Scheme 3 Enantioselectivity of metal–organic frameworks (MOFs) for alkylation of indoles and pyrroles
Reprinted from the journal
157