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86. Benítez T, Rincón AM, Limón MC, Codón AC (2004) Biocontrol mechanisms of Trichoderma strains. Int Microbiol 7:249–260
87. Lehner SM, Atanasova L, Neumann NK, Krska R, Lemmens M, Druzhinina IS, Schuhmacher
R (2013) Isotope-assisted screening for iron-containing metabolites reveals a high degree of
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88. Renshaw JC, Robson GD, Trinci APJ, Wiebe MG, Livens FR, Collison D, Taylor RJ (2002)
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89. Vinale F, Nigro M, Sivasithamparam K, Flematti G, Ghisalberti EL, Ruocco M, Varlese R,
Marra R, Lanzuise S, Eid A, Woo SL, Lorito M (2013) Harzianic acid: a novel siderophore
from Trichoderma harzianum. FEMS Microbiol Lett 347:123–129. https://doi.org/10.1111/
1574-6968.12231
90. Sivasithamparam K, Ghisalberti EL (1998) Secondary metabolism in Trichoderma and
Gliocladium. In: Kubicek CP, Harman GE (eds) Trichoderma and Gliocladium. Taylor and
Francis, London, pp 139–191
91. Scarselletti R, Faull JL (1994) In vitro activity of 6-pentyl-α-pyrone, a metabolite of Trichoderma harzianum, in the inhibition of Rhizoctonia solani and Fusarium oxysporum f. sp.
lycopersici. Mycol Res 98:1207–1209. https://doi.org/10.1016/S0953-7562(09)80206-2
92. Cooney JM, Lauren DR, Di Menna ME (2001) Impact of competitive fungi on trichothecene
production by Fusarium graminearum. J Agric Food Chem 49:522–526. https://doi.org/
10.1021/jf0006372
93. Itoh Y, Kodama K, Furuya K, Takahashi S, Haneishi T, Takiguchi Y, Arai M (1980) A new
sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and
characterization. J Antibiot 33:468–473. https://doi.org/10.7164/antibiotics.33.468
94. Almassi F, Ghisalberti EL, Narbey MJ, Sivasithamparam K (1991) New antibiotics from
strains of Trichoderma harzianum. J Nat Prod 54:396–402. https://doi.org/10.1021/
np50074a008
95. Agarwal SK, Singh SS, Verma S, Kumar S (2000) Antifungal activity of anthraquinone
derivatives from Rheum emodi. J Ethnopharmacol 72:43–46. https://doi.org/10.1016/S03788741(00)00195-1
96. Coats JH, Meyer CE, Pyke TR (1971) Antibiotic dermadin. US Patent 3,627,882, 14 Dec 1971
97. Chukwujekwu JC, Coombes PH, Mulholland DA, van Staden J (2006) Emodin, an antibacterial anthraquinone from the roots of Cassia occidentalis. S Afr J Bot 72:295–297. https://
doi.org/10.1016/j.sajb.2005.08.003
288
H. A. Contreras-Cornejo et al.
81. Vinale F, Arjona Girona I, Nigro M, Mazzei P, Piccolo A, Ruocco M, Woo S, Ruano Rosa R,
López Herrera C, Lorito M (2011) Cerinolactone, a hydroxyl-lactone derivative from Trichoderma cerinum. J Nat Prod 75:103–106. https://doi.org/10.1021/np200577t
82. Omann MR, Lehner S, Escobar-Rodríguez C, Brunner K, Zeilinger S (2012) The seventransmembrane receptor Gpr1 governs processes relevant for the antagonistic interaction of
Trichoderma atroviride with its host. Microbiology 158:107–118. https://doi.org/10.1099/
mic.0.052035-0
83. Lin YR, Lo CT, Li SY, Peng KC (2012) Involvement of pachybasin and emodin in selfregulation of Trichoderma harzianum mycoparasitic coiling. J Agric Food Chem
60:2123–2128. https://doi.org/10.1021/jf202773y
84. Miyadera H, Shiomi K, Ui H, Yamaguchi Y, Masuma R, Tomoda H, Miyoshi H, Osanai A,
Kita K, Omura S (2003) Atpenins, potent and specific inhibitors of mitochondrial complex II
(succinate-ubiquinone oxidoreductase). Proc Natl Acad Sci USA 100:473–477. https://doi.
org/10.1073/pnas.0237315100
85. Seidl V, Song L, Lindquistv E, Gruber S, Koptchinskiy A, Zeilinger S, Schmoll M, Martínez P,
Sun J, Grigoriev I, Herrera-Estrella A, Baker SE, Kubicek CP (2009) Transcriptomic response
of the mycoparasitic fungus Trichoderma atroviride to the presence of a fungal prey. BMC
Genomics 10:567. https://doi.org/10.1186/1471-2164-10-567
86. Benítez T, Rincón AM, Limón MC, Codón AC (2004) Biocontrol mechanisms of Trichoderma strains. Int Microbiol 7:249–260
87. Lehner SM, Atanasova L, Neumann NK, Krska R, Lemmens M, Druzhinina IS, Schuhmacher
R (2013) Isotope-assisted screening for iron-containing metabolites reveals a high degree of
diversity among known and unknown siderophores produced by Trichoderma spp. Appl
Environ Microbiol 79:18–31. https://doi.org/10.1128/AEM.02339-12
88. Renshaw JC, Robson GD, Trinci APJ, Wiebe MG, Livens FR, Collison D, Taylor RJ (2002)
Fungal siderophores: structures, functions, and applications. Mycol Res 106:1123–1142.
https://doi.org/10.1017/S0953756202006548
89. Vinale F, Nigro M, Sivasithamparam K, Flematti G, Ghisalberti EL, Ruocco M, Varlese R,
Marra R, Lanzuise S, Eid A, Woo SL, Lorito M (2013) Harzianic acid: a novel siderophore
from Trichoderma harzianum. FEMS Microbiol Lett 347:123–129. https://doi.org/10.1111/
1574-6968.12231
90. Sivasithamparam K, Ghisalberti EL (1998) Secondary metabolism in Trichoderma and
Gliocladium. In: Kubicek CP, Harman GE (eds) Trichoderma and Gliocladium. Taylor and
Francis, London, pp 139–191
91. Scarselletti R, Faull JL (1994) In vitro activity of 6-pentyl-α-pyrone, a metabolite of Trichoderma harzianum, in the inhibition of Rhizoctonia solani and Fusarium oxysporum f. sp.
lycopersici. Mycol Res 98:1207–1209. https://doi.org/10.1016/S0953-7562(09)80206-2
92. Cooney JM, Lauren DR, Di Menna ME (2001) Impact of competitive fungi on trichothecene
production by Fusarium graminearum. J Agric Food Chem 49:522–526. https://doi.org/
10.1021/jf0006372
93. Itoh Y, Kodama K, Furuya K, Takahashi S, Haneishi T, Takiguchi Y, Arai M (1980) A new
sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and
characterization. J Antibiot 33:468–473. https://doi.org/10.7164/antibiotics.33.468
94. Almassi F, Ghisalberti EL, Narbey MJ, Sivasithamparam K (1991) New antibiotics from
strains of Trichoderma harzianum. J Nat Prod 54:396–402. https://doi.org/10.1021/
np50074a008
95. Agarwal SK, Singh SS, Verma S, Kumar S (2000) Antifungal activity of anthraquinone
derivatives from Rheum emodi. J Ethnopharmacol 72:43–46. https://doi.org/10.1016/S03788741(00)00195-1
96. Coats JH, Meyer CE, Pyke TR (1971) Antibiotic dermadin. US Patent 3,627,882, 14 Dec 1971
97. Chukwujekwu JC, Coombes PH, Mulholland DA, van Staden J (2006) Emodin, an antibacterial anthraquinone from the roots of Cassia occidentalis. S Afr J Bot 72:295–297. https://
doi.org/10.1016/j.sajb.2005.08.003
288
H. A. Contreras-Cornejo et al.