48. Sawa R, Mori Y, Iinuma H, Naganawa H, Hamada M, Yoshida S, Furutani H, Kajimura Y,
Fuwa T, Takeuchi T (1994) Harzianic acid, a new antimicrobial antibiotic from a fungus.
J Antibiot 47:731–732. https://doi.org/10.7164/antibiotics.47.731
49. Kawada M, Yoshimoto Y, Kumagai H, Someno T, Momose I, Kawamura N, Isshiki K, Ikeda D
(2004) PP2A inhibitors, harzianic acid and related compounds produced by fungal strain
F-1531. J Antibiot 57:235–237. https://doi.org/10.7164/antibiotics.57.235
50. Vinale F, Flematti G, Sivasithamparam K, Lorito M, Marra R, Skelton BW, Ghisalberti EL
(2009) Harzianic acid, an antifungal and plant growth promoting metabolite from Trichoderma
harzianum. J Nat Prod 72:2032–2035. https://doi.org/10.1021/np900548p
51. Vinale F, Sivasithamparam K, Ghisalberti EL, Woo SL, Nigro M, Marra R, Lombardi N,
Pascale A, Ruocco M, Lanzuise S, Manganiello G, Lorito M (2014) Trichoderma secondary
metabolites active on plants and fungal pathogens. Open Mycol J 8:127–139. https://doi.org/
10.2174/1874437001408010127
52. Marfori EC, Kajiyama S, Fukusaki E, Kobayashi A (2003) Phytotoxicity of the tetramic acid
metabolite trichosetin. Phytochemistry 62:715–721. https://doi.org/10.1016/S0031-9422(02)
00629-5
53. Kishimoto K, Matsui K, Ozawa R, Takabayashi J (2007) Volatile 1-octen-3-ol induces a
defensive response in Arabidopsis thaliana. J Gen Plant Pathol 73:35–37. https://doi.org/
10.1007/s10327-006-0314-8
54. Degenkolb T, Dieckmann R, Nielsen KF, Gräfenhan T, Theis C, Zafari D, Chaverri P, Ismaiel
A, Brückner H, von Döhren H, Thrane U, Petrini O, Samuels GJ (2008) The Trichoderma
brevicompactum clade: a separate lineage with new species, new peptabiotics, and mycotoxins. Mycol Prog 7:177–219. https://doi.org/10.1007/s11557-008-0563-3
55. Malmierca MG, Cardoza RE, Alexander NJ, McCormick SP, Collado IG, Hermosa R, Monte
E, Gutiérrez S (2013) Relevance of trichothecenes in fungal physiology: Disruption of tri5 in
Trichoderma arundinaceum. Fungal Genet Biol 53:22–33. https://doi.org/10.1016/j.
fgb.2013.02.001
56. Malmierca MG, Cardoza RE, Alexander NJ, McCormick SP, Hermosa R, Monte E, Gutiérrez
S (2012) Involvement of Trichoderma trichothecenes in the biocontrol activity and induction
of plant defense-related genes. Appl Environ Microbiol 78:4856–4868. https://doi.org/
10.1128/AEM.00385-12
57. Malmierca MG, McCormick SP, Cardoza RE, Monte E, Alexander NJ, Gutiérrez S (2015)
Trichodiene production in a Trichoderma harzianum erg1-silenced strain provides evidence of
the importance of the sterol biosynthetic pathway in inducing plant defense-related gene
expression. Mol Plant-Microbe Interact 28:1181–1197. https://doi.org/10.1094/MPMI-0615-0127-R
58. Djonović S, Pozo MJ, Dangott LJ, Howell CR, Kenerley CM (2006) Sm1, a proteinaceous
elicitor by the biocontrol fungus Trichoderma virens induces plant defense responses and
systemic resistance. Mol Plant-Microbe Interact 19:838–853
59. Djonović S, Vargas WA, Kolomiets MV, Horndeski M, Wiest A, Kenerley CM (2007)
A proteinaceous elicitor Sm1 from the beneficial fungus Trichoderma virens is required for
induced systemic resistance in maize. Plant Physiol 145:875–889. https://doi.org/10.1104/
pp.107.103689
60. Vargas WA, Djonović S, Sukno SA, Kenerley CM (2008) Dimerization controls the activity of
fungal elicitors that trigger systemic resistance in plants. J Biol Chem 283:19804–19815.
https://doi.org/10.1074/jbc.M802724200
61. Cheng CH, Shen BN, Shang QW, Liu LYD, Peng KC, Chen YH, Chen FF, Hu SF, Wang
YT, Wang HC, Wu HY, Lo CT, Lin SS (2018) Gene-to-gene network analysis of the
mediation of plant innate immunity by the eliciting plant response-like 1 (Epl1) elicitor
of Trichoderma formosa. Mol Plant-Microbe Interact 31:683. https://doi.org/10.1094/
MPMI-01-18-0002-TA
62. Ruocco M, Lanzuise S, Lombardi N, Woo SL, Vinale F, Marra R, Varlese R, Manganiello G,
Pascale A, Scala V, Turrà D, Scala F, Lorito M (2015) Multiple roles and effects of a novel
286
H. A. Contreras-Cornejo et al.
Fuwa T, Takeuchi T (1994) Harzianic acid, a new antimicrobial antibiotic from a fungus.
J Antibiot 47:731–732. https://doi.org/10.7164/antibiotics.47.731
49. Kawada M, Yoshimoto Y, Kumagai H, Someno T, Momose I, Kawamura N, Isshiki K, Ikeda D
(2004) PP2A inhibitors, harzianic acid and related compounds produced by fungal strain
F-1531. J Antibiot 57:235–237. https://doi.org/10.7164/antibiotics.57.235
50. Vinale F, Flematti G, Sivasithamparam K, Lorito M, Marra R, Skelton BW, Ghisalberti EL
(2009) Harzianic acid, an antifungal and plant growth promoting metabolite from Trichoderma
harzianum. J Nat Prod 72:2032–2035. https://doi.org/10.1021/np900548p
51. Vinale F, Sivasithamparam K, Ghisalberti EL, Woo SL, Nigro M, Marra R, Lombardi N,
Pascale A, Ruocco M, Lanzuise S, Manganiello G, Lorito M (2014) Trichoderma secondary
metabolites active on plants and fungal pathogens. Open Mycol J 8:127–139. https://doi.org/
10.2174/1874437001408010127
52. Marfori EC, Kajiyama S, Fukusaki E, Kobayashi A (2003) Phytotoxicity of the tetramic acid
metabolite trichosetin. Phytochemistry 62:715–721. https://doi.org/10.1016/S0031-9422(02)
00629-5
53. Kishimoto K, Matsui K, Ozawa R, Takabayashi J (2007) Volatile 1-octen-3-ol induces a
defensive response in Arabidopsis thaliana. J Gen Plant Pathol 73:35–37. https://doi.org/
10.1007/s10327-006-0314-8
54. Degenkolb T, Dieckmann R, Nielsen KF, Gräfenhan T, Theis C, Zafari D, Chaverri P, Ismaiel
A, Brückner H, von Döhren H, Thrane U, Petrini O, Samuels GJ (2008) The Trichoderma
brevicompactum clade: a separate lineage with new species, new peptabiotics, and mycotoxins. Mycol Prog 7:177–219. https://doi.org/10.1007/s11557-008-0563-3
55. Malmierca MG, Cardoza RE, Alexander NJ, McCormick SP, Collado IG, Hermosa R, Monte
E, Gutiérrez S (2013) Relevance of trichothecenes in fungal physiology: Disruption of tri5 in
Trichoderma arundinaceum. Fungal Genet Biol 53:22–33. https://doi.org/10.1016/j.
fgb.2013.02.001
56. Malmierca MG, Cardoza RE, Alexander NJ, McCormick SP, Hermosa R, Monte E, Gutiérrez
S (2012) Involvement of Trichoderma trichothecenes in the biocontrol activity and induction
of plant defense-related genes. Appl Environ Microbiol 78:4856–4868. https://doi.org/
10.1128/AEM.00385-12
57. Malmierca MG, McCormick SP, Cardoza RE, Monte E, Alexander NJ, Gutiérrez S (2015)
Trichodiene production in a Trichoderma harzianum erg1-silenced strain provides evidence of
the importance of the sterol biosynthetic pathway in inducing plant defense-related gene
expression. Mol Plant-Microbe Interact 28:1181–1197. https://doi.org/10.1094/MPMI-0615-0127-R
58. Djonović S, Pozo MJ, Dangott LJ, Howell CR, Kenerley CM (2006) Sm1, a proteinaceous
elicitor by the biocontrol fungus Trichoderma virens induces plant defense responses and
systemic resistance. Mol Plant-Microbe Interact 19:838–853
59. Djonović S, Vargas WA, Kolomiets MV, Horndeski M, Wiest A, Kenerley CM (2007)
A proteinaceous elicitor Sm1 from the beneficial fungus Trichoderma virens is required for
induced systemic resistance in maize. Plant Physiol 145:875–889. https://doi.org/10.1104/
pp.107.103689
60. Vargas WA, Djonović S, Sukno SA, Kenerley CM (2008) Dimerization controls the activity of
fungal elicitors that trigger systemic resistance in plants. J Biol Chem 283:19804–19815.
https://doi.org/10.1074/jbc.M802724200
61. Cheng CH, Shen BN, Shang QW, Liu LYD, Peng KC, Chen YH, Chen FF, Hu SF, Wang
YT, Wang HC, Wu HY, Lo CT, Lin SS (2018) Gene-to-gene network analysis of the
mediation of plant innate immunity by the eliciting plant response-like 1 (Epl1) elicitor
of Trichoderma formosa. Mol Plant-Microbe Interact 31:683. https://doi.org/10.1094/
MPMI-01-18-0002-TA
62. Ruocco M, Lanzuise S, Lombardi N, Woo SL, Vinale F, Marra R, Varlese R, Manganiello G,
Pascale A, Scala V, Turrà D, Scala F, Lorito M (2015) Multiple roles and effects of a novel
286
H. A. Contreras-Cornejo et al.