metabolism in Chinese flowering cabbage (Brassica parachinensis). J Hazard Mater
349:252–261
51. Macherius A, Eggen T, Lorenz W, Moeder M, Ondruschka J, Reemtsma T (2012)
Metabolization of the bacteriostatic agent triclosan in edible plants and its consequences for
plant uptake assessment. Environ Sci Technol 46:10797–10804
52. Wang Y, Chan KKJ, Chan W (2017) Plant uptake and metabolism of nitrofuran antibiotics in
spring onion grown in nitrofuran-contaminated soil. J Agric Food Chem 65:4255–4261
53. Emhofer L, Himmelsbach M, Buchberger W, Klampfl CW (2017) High-performance liquid
chromatography – mass spectrometry analysis of the parent drugs and their metabolites in
extracts from cress (Lepidium sativum) grown hydroponically in water containing four
non-steroidal anti-inflammatory drugs. J Chromatogr A 1491:137–144
54. Emhofer L, Himmelsbach M, Buchberger W, Klampfl CW (2019) High-performance liquid
chromatography drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the
identity confirmation and characterization of metabolites from three statins (lipid-lowering
drugs) in the model plant cress (Lepidium sativum) after uptake from water. J Chromatogr A
1592:122–132
55. Reichl B, Himmelsbach M, Emhofer L, Klampfl CW, Buchberger W (2018) Uptake and
metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress
(Lepidium sativum) model. Electrophoresis 39:1301–1308
56. Macherius A, Seiwert B, Schröder P, Huber C, Lorenz W, Reemtsma T (2014) Identification of
plant metabolites of environmental contaminants by UPLC-QToF-MS: the in vitro metabolism
of triclosan in horseradish. J Agric Food Chem 62:1001–1009
57. Sauvêtre A, May R, Harpaintner R, Poschenrieder C, Schröder P (2018) Metabolism of
carbamazepine in plant roots and endophytic rhizobacteria isolated from Phragmites australis.
J Hazard Mater 342:85–95
58. Huber C, Bartha B, Schröder P (2012) Metabolism of diclofenac in plants – hydroxylation is
followed by glucose conjugation. J Hazard Mater 243:250–256
59. Carter LJ, Williams M, Martin S, Kamaludeen SPB, Kookana RS (2018) Sorption, plant uptake
and metabolism of benzodiazepines. Sci Total Environ 628-629:18–25
60. Fu Q, Ye Q, Zhang J, Richards J, Borchardt D, Gan J (2017) Diclofenac in Arabidopsis cells:
rapid formation of conjugates. Environ Pollut 222:383–392
61. Stuchlíková Raisová L, Podlipná R, Szotáková B, Syslová E, Skálová L (2017) Evaluation of
drug uptake and deactivation in plants: fate of albendazole in ribwort plantain (Plantago
lanceolata) cells and regenerants. Ecotoxicol Environ Saf 141:37–42
62. Chen F, Huber C, May R, Schröder P (2016) Metabolism of oxybenzone in a hairy root culture:
perspectives for phytoremediation of a widely used sunscreen agent. J Hazard Mater
306:230–236
63. Fu Q, Dudley S, Sun C, Schlenk D, Gan J (2018) Stable isotope labeling-assisted metabolite
probing for emerging contaminants in plants. Anal Chem 90:11040–11047
64. Riemenschneider C, Seiwert B, Goldstein M, Al-Raggad M, Salameh E, Chefetz B, Reemtsma
T (2017) An LC-MS/MS method for the determination of 28 polar environmental contaminants
and metabolites in vegetables irrigated with treated municipal wastewater. Anal Methods
9:1273–1281
65. Dordio AV, Belo M, Martins Teixeira D, Palace Carvalho AJ, Dias CMB, Picó Y, Pinto AP
(2011) Evaluation of carbamazepine uptake and metabolization by Typha spp., a plant with
potential use in phytotreatment. Bioresour Technol 102:7827–7834
66. Barker SA (2007) Matrix solid phase dispersion. J Biochem Biophys Methods 70:151–162
67. Villette C, Maurer L, Wanko A, Heintz D (2019) Xenobiotics metabolization in Salix alba
leaves uncovered by mass spectrometry imaging. Metabolomics 15:122
68. Schymanski EL, Jeon J, Gulde R, Fenner K, Ruff M, Singer HP, Hollender J (2014) Identifying
small molecules via high resolution mass spectrometry: communicating confidence. Environ
Sci Technol 48:2097–2098
Analytical Approaches for the Determination and Identification of Drug. . .
521
349:252–261
51. Macherius A, Eggen T, Lorenz W, Moeder M, Ondruschka J, Reemtsma T (2012)
Metabolization of the bacteriostatic agent triclosan in edible plants and its consequences for
plant uptake assessment. Environ Sci Technol 46:10797–10804
52. Wang Y, Chan KKJ, Chan W (2017) Plant uptake and metabolism of nitrofuran antibiotics in
spring onion grown in nitrofuran-contaminated soil. J Agric Food Chem 65:4255–4261
53. Emhofer L, Himmelsbach M, Buchberger W, Klampfl CW (2017) High-performance liquid
chromatography – mass spectrometry analysis of the parent drugs and their metabolites in
extracts from cress (Lepidium sativum) grown hydroponically in water containing four
non-steroidal anti-inflammatory drugs. J Chromatogr A 1491:137–144
54. Emhofer L, Himmelsbach M, Buchberger W, Klampfl CW (2019) High-performance liquid
chromatography drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the
identity confirmation and characterization of metabolites from three statins (lipid-lowering
drugs) in the model plant cress (Lepidium sativum) after uptake from water. J Chromatogr A
1592:122–132
55. Reichl B, Himmelsbach M, Emhofer L, Klampfl CW, Buchberger W (2018) Uptake and
metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress
(Lepidium sativum) model. Electrophoresis 39:1301–1308
56. Macherius A, Seiwert B, Schröder P, Huber C, Lorenz W, Reemtsma T (2014) Identification of
plant metabolites of environmental contaminants by UPLC-QToF-MS: the in vitro metabolism
of triclosan in horseradish. J Agric Food Chem 62:1001–1009
57. Sauvêtre A, May R, Harpaintner R, Poschenrieder C, Schröder P (2018) Metabolism of
carbamazepine in plant roots and endophytic rhizobacteria isolated from Phragmites australis.
J Hazard Mater 342:85–95
58. Huber C, Bartha B, Schröder P (2012) Metabolism of diclofenac in plants – hydroxylation is
followed by glucose conjugation. J Hazard Mater 243:250–256
59. Carter LJ, Williams M, Martin S, Kamaludeen SPB, Kookana RS (2018) Sorption, plant uptake
and metabolism of benzodiazepines. Sci Total Environ 628-629:18–25
60. Fu Q, Ye Q, Zhang J, Richards J, Borchardt D, Gan J (2017) Diclofenac in Arabidopsis cells:
rapid formation of conjugates. Environ Pollut 222:383–392
61. Stuchlíková Raisová L, Podlipná R, Szotáková B, Syslová E, Skálová L (2017) Evaluation of
drug uptake and deactivation in plants: fate of albendazole in ribwort plantain (Plantago
lanceolata) cells and regenerants. Ecotoxicol Environ Saf 141:37–42
62. Chen F, Huber C, May R, Schröder P (2016) Metabolism of oxybenzone in a hairy root culture:
perspectives for phytoremediation of a widely used sunscreen agent. J Hazard Mater
306:230–236
63. Fu Q, Dudley S, Sun C, Schlenk D, Gan J (2018) Stable isotope labeling-assisted metabolite
probing for emerging contaminants in plants. Anal Chem 90:11040–11047
64. Riemenschneider C, Seiwert B, Goldstein M, Al-Raggad M, Salameh E, Chefetz B, Reemtsma
T (2017) An LC-MS/MS method for the determination of 28 polar environmental contaminants
and metabolites in vegetables irrigated with treated municipal wastewater. Anal Methods
9:1273–1281
65. Dordio AV, Belo M, Martins Teixeira D, Palace Carvalho AJ, Dias CMB, Picó Y, Pinto AP
(2011) Evaluation of carbamazepine uptake and metabolization by Typha spp., a plant with
potential use in phytotreatment. Bioresour Technol 102:7827–7834
66. Barker SA (2007) Matrix solid phase dispersion. J Biochem Biophys Methods 70:151–162
67. Villette C, Maurer L, Wanko A, Heintz D (2019) Xenobiotics metabolization in Salix alba
leaves uncovered by mass spectrometry imaging. Metabolomics 15:122
68. Schymanski EL, Jeon J, Gulde R, Fenner K, Ruff M, Singer HP, Hollender J (2014) Identifying
small molecules via high resolution mass spectrometry: communicating confidence. Environ
Sci Technol 48:2097–2098
Analytical Approaches for the Determination and Identification of Drug. . .
521