for untargeted metabolomic analyses of biological samples: a tutorial. Anal Chim Acta
1105:28–44
32. Gika H, Virgiliou C, Theodoridis G, Plumbe RS, Wilson ID (2019) Untargeted LC/MS-based
metabolic phenotyping (metabonomics/metabolomics): the state of the art. J Chromatogr B
1117:136–147
33. Wu X, Conkle JL, Ernst F, Gan J (2014) Treated wastewater irrigation: uptake of pharmaceutical and personal care products by common vegetables under field conditions. Environ Sci
Technol 48:11286–11293
34. Herklotz PA, Gurung P, van den Heuvel B, Kinney CA (2010) Uptake of human pharmaceuticals by plants grown under hydroponic conditions. Chemosphere 78:1416–1421
35. Emhofer L, Himmelsbach M, Buchberger W, Klampfl CW (2018) Insights into the uptake,
metabolization and translocation of four non-steroidal anti-inflammatory drugs in cress
(Lepidium sativum) by HPLC-MS
2
. Electrophoresis 39:1294–1300
36. Huber C, Bartha B, Harpaintner R, Schröder P (2009) Metabolism of acetaminophen (paracetamol) in plants—two independent pathways result in the formation of a glutathione and a
glucose conjugate. Environ Sci Pollut Res 16:206–213
37. Ben Mordechay E, Tarchitzky J, Chen Y, Shenker M, Chefetz B (2018) Composted biosolids
and treated wastewater as sources of pharmaceuticals and personal care products for plant
uptake: a case study with carbamazepine. Environ Pollut 232:164–172
38. Riemenschneider C, Seiwert B, Moeder M, Schwarz D, Reemtsma T (2017) Extensive transformation of the pharmaceutical carbamazepine following uptake into intact tomato plants.
Environ Sci Technol 51:6100–6109
39. Tadić D, Matamoros V, Bayona JM (2019) Simultaneous determination of multiclass antibiotics and their metabolites in four types of field-grown vegetables. Anal Bioanal Chem
411:5209–5222
40. Mlynek F, Himmelsbach M, Buchberger W, Klampfl CW (2020) A new analytical workflow
using HPLC with drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the
detection of drug-related metabolites in plants. Anal Bioanal Chem 412:1817–1824
41. Sun C, Dudley S, McGinnis M, Trumble J, Gan J (2019) Acetaminophen detoxification in
cucumber plants via induction of glutathione S-transferases. Sci Total Environ 649:431–439
42. Dudley S, Sun C, Jiang J, Gan J (2018) Metabolism of sulfamethoxazole in Arabidopsis
thaliana cells and cucumber seedlings. Environ Pollut 242:1748–1757
43. Goldstein M, Malchi T, Shenker M, Chefetz B (2018) Pharmacokinetics in plants: carbamazepine and its interactions with lamotrigine. Environ Sci Technol 52:6957–6964
44. Hurtado C, Domínguez C, Clapés P, Bayona JM (2018) Determination of the β-glycosylate
fraction of contaminants of emerging concern in lettuce (Lactuca sativa L.) grown under
controlled conditions. Anal Bioanal Chem 410:5715–5721
45. Martínez-Piernas AB, Nahim-Granados S, Polo-López MI, Fernández-Ibáñez PI, Murgolo S,
Mascolo G, Agüera A (2019) Identification of transformation products of carbamazepine in
lettuce crops irrigated with ultraviolet-C treated water. Environ Pollut 247:1009–1019
46. Chuang Y-H, Liu C-H, Hammerschmidt R, Zhang W, Boyd SA, Li H (2018) Metabolic
demethylation and oxidation of caffeine during uptake by lettuce. J Agric Food Chem
66:7907–7915
47. Kodešová R, Klement A, Golovko O, Fér M, Nikodem A, Kočárek M, Grabic R (2019) Root
uptake of atenolol, sulfamethoxazole and carbamazepine, and their transformation in three soils
and four plants. Environ Sci Pollut Res 26:9876–9891
48. Tian R, Zhang R, Uddin M, Qiao X, Chen J, Gu G (2019) Uptake and metabolism of
clarithromycin and sulfadiazine in lettuce. Environ Pollut 247:1134–1142
49. Adeel M, Yang YS, Wang YY, Song XM, Ahmad MA, Rogers HJ (2018) Uptake and
transformation of steroid estrogens as emerging contaminants influence plant development.
Environ Pollut 243:1487–1497
50. Zhao H-M, Huang H-B, Du H, Lin J, Xiang L, Li Y-W, Cai Q-Y, Li H, Mo C-H, Liu J-S, Wong
M-H, Zhou D-M (2018) Intraspecific variability of ciprofloxacin accumulation, tolerance, and
520
F. Mlynek et al.
1105:28–44
32. Gika H, Virgiliou C, Theodoridis G, Plumbe RS, Wilson ID (2019) Untargeted LC/MS-based
metabolic phenotyping (metabonomics/metabolomics): the state of the art. J Chromatogr B
1117:136–147
33. Wu X, Conkle JL, Ernst F, Gan J (2014) Treated wastewater irrigation: uptake of pharmaceutical and personal care products by common vegetables under field conditions. Environ Sci
Technol 48:11286–11293
34. Herklotz PA, Gurung P, van den Heuvel B, Kinney CA (2010) Uptake of human pharmaceuticals by plants grown under hydroponic conditions. Chemosphere 78:1416–1421
35. Emhofer L, Himmelsbach M, Buchberger W, Klampfl CW (2018) Insights into the uptake,
metabolization and translocation of four non-steroidal anti-inflammatory drugs in cress
(Lepidium sativum) by HPLC-MS
2
. Electrophoresis 39:1294–1300
36. Huber C, Bartha B, Harpaintner R, Schröder P (2009) Metabolism of acetaminophen (paracetamol) in plants—two independent pathways result in the formation of a glutathione and a
glucose conjugate. Environ Sci Pollut Res 16:206–213
37. Ben Mordechay E, Tarchitzky J, Chen Y, Shenker M, Chefetz B (2018) Composted biosolids
and treated wastewater as sources of pharmaceuticals and personal care products for plant
uptake: a case study with carbamazepine. Environ Pollut 232:164–172
38. Riemenschneider C, Seiwert B, Moeder M, Schwarz D, Reemtsma T (2017) Extensive transformation of the pharmaceutical carbamazepine following uptake into intact tomato plants.
Environ Sci Technol 51:6100–6109
39. Tadić D, Matamoros V, Bayona JM (2019) Simultaneous determination of multiclass antibiotics and their metabolites in four types of field-grown vegetables. Anal Bioanal Chem
411:5209–5222
40. Mlynek F, Himmelsbach M, Buchberger W, Klampfl CW (2020) A new analytical workflow
using HPLC with drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the
detection of drug-related metabolites in plants. Anal Bioanal Chem 412:1817–1824
41. Sun C, Dudley S, McGinnis M, Trumble J, Gan J (2019) Acetaminophen detoxification in
cucumber plants via induction of glutathione S-transferases. Sci Total Environ 649:431–439
42. Dudley S, Sun C, Jiang J, Gan J (2018) Metabolism of sulfamethoxazole in Arabidopsis
thaliana cells and cucumber seedlings. Environ Pollut 242:1748–1757
43. Goldstein M, Malchi T, Shenker M, Chefetz B (2018) Pharmacokinetics in plants: carbamazepine and its interactions with lamotrigine. Environ Sci Technol 52:6957–6964
44. Hurtado C, Domínguez C, Clapés P, Bayona JM (2018) Determination of the β-glycosylate
fraction of contaminants of emerging concern in lettuce (Lactuca sativa L.) grown under
controlled conditions. Anal Bioanal Chem 410:5715–5721
45. Martínez-Piernas AB, Nahim-Granados S, Polo-López MI, Fernández-Ibáñez PI, Murgolo S,
Mascolo G, Agüera A (2019) Identification of transformation products of carbamazepine in
lettuce crops irrigated with ultraviolet-C treated water. Environ Pollut 247:1009–1019
46. Chuang Y-H, Liu C-H, Hammerschmidt R, Zhang W, Boyd SA, Li H (2018) Metabolic
demethylation and oxidation of caffeine during uptake by lettuce. J Agric Food Chem
66:7907–7915
47. Kodešová R, Klement A, Golovko O, Fér M, Nikodem A, Kočárek M, Grabic R (2019) Root
uptake of atenolol, sulfamethoxazole and carbamazepine, and their transformation in three soils
and four plants. Environ Sci Pollut Res 26:9876–9891
48. Tian R, Zhang R, Uddin M, Qiao X, Chen J, Gu G (2019) Uptake and metabolism of
clarithromycin and sulfadiazine in lettuce. Environ Pollut 247:1134–1142
49. Adeel M, Yang YS, Wang YY, Song XM, Ahmad MA, Rogers HJ (2018) Uptake and
transformation of steroid estrogens as emerging contaminants influence plant development.
Environ Pollut 243:1487–1497
50. Zhao H-M, Huang H-B, Du H, Lin J, Xiang L, Li Y-W, Cai Q-Y, Li H, Mo C-H, Liu J-S, Wong
M-H, Zhou D-M (2018) Intraspecific variability of ciprofloxacin accumulation, tolerance, and
520
F. Mlynek et al.