10. Voulvoulis N (2018) Water reuse from a circular economy perspective and potential risks from
an unregulated approach. Curr Opin Environ Sci Health 2:32–45
11. Deviller G, Lundy L, Fatta-Kassinos D (2020) Recommendations to derive quality standards for
chemical pollutants in reclaimed water intended for reuse in agricultural irrigation.
Chemosphere 240:124911
12. Wu X, Dodgen LK, Conkle JL, Gan J (2015) Plant uptake of pharmaceutical and personal care
products from recycled water and biosolids: a review. Sci Total Environ 536:655–666
13. Kaczala F, Blum SE (2016) The occurrence of veterinary pharmaceuticals in the environment: a
review. Curr Anal Chem 12:169–182
14. Bártíková H, Podlipná R, Skálová L (2016) Veterinary drugs in the environment and their
toxicity to plants. Chemosphere 144:2290–2301
15. Christou A, Papadavid G, Dalias P, Fotopoulos V, Michael C, Bayona JM, Piña B, Madikizela
LM, Ncube S, Chimuka L (2018) Uptake of pharmaceuticals by plants grown under hydroponic
conditions and natural occurring plant species: a review. Sci Total Environ 636:477–486
16. Bartrons M, Peñuelas J (2017) Pharmaceuticals and personal-care products in plants. Trends
Plant Sci 22:194–203
17. Madikizela LM, Ncube S, Chimuka L (2018) Uptake of pharmaceuticals by plants grown under
hydroponic conditions and natural occurring plant species: a review. Sci Total Environ
636:477–486
18. Reddy Pullagurala VL, Rawat S, Adisa IO, Hernandez-Viezcas JA, Peralta-Videa JR, GardeaTorresdey JL (2018) Plant uptake and translocation of contaminants of emerging concern in
soil. Sci Total Environ 636:1585–1596
19. Pico Y, Alfarham A, Barcelo D (2017) Analysis of emerging contaminants and nanomaterials in
plant materials following uptake from soils. Trends Anal Chem 94:173–189
20. Miller EL, Nason SL, Karthikeyan KG, Pedersen JA (2016) Root uptake of pharmaceuticals and
personal care product ingredients. Environ Sci Technol 50:525–541
21. Carvalho PN, Basto MCP, Almeida CMR, Brix H (2014) A review of plant–pharmaceutical
interactions: from uptake and effects in crop plants to phytoremediation in constructed wetlands. Environ Sci Pollut Res 21:11729–11763
22. Goldstein M, Shenker M, Chefetz B (2014) Insights into the uptake processes of wastewaterborne pharmaceuticals by vegetables. Environ Sci Technol 48:5593–5600
23. Kinney CA, Vanden Heuvel B (2020) Translocation of pharmaceuticals and personal care
products after land application of biosolids. Curr Opin Environ Sci Health 14:23–30
24. Fu Q, Malchi T, Carter LJ, Li H, Gan J, Chefetz B (2019) Pharmaceutical and personal care
products: from wastewater treatment into agro-food systems. Environ Sci Technol
53:14083–14090
25. Klampfl CW (2019) Metabolization of pharmaceuticals by plants after uptake from water and
soil: a review. Trends Anal Chem 111:13–26
26. Bártíková H, Skálová L, Stuchlíková L, Vokřál I, Vaněk T, Podlipná R (2015) Xenobioticmetabolizing enzymes in plants and their role in uptake and biotransformation of veterinary
drugs in the environment. Drug Metab Rev 47:374–387
27. Cummins I, Dixon DP, Freitag-Pohl S, Skipsey M, Edwards R (2011) Multiple roles for plant
glutathione transferases in xenobiotic detoxification. Drug Metab Rev 43:266–280
28. Fu Q, Zhang J, Borchardt D, Schlenk D, Gan J (2017) Direct conjugation of emerging
contaminants in arabidopsis: indication for an overlooked risk in plants? Environ Sci Technol
51:6071–6081
29. Kazmi SR, Jun R, Yu M-S, Jung C, Na D (2019) In silico approaches and tools for the
prediction of drug metabolism and fate: a review. Comput Biol Med 106:54–64
30. Nash WJ, Dunn WB (2019) From mass to metabolite in human untargeted metabolomics: recent
advances in annotation of metabolites applying liquid chromatography-mass spectrometry data.
Trends Anal Chem 120:115324
31. Pezzatti J, Boccard J, Codesido S, Gagnebin Y, Joshi A, Picard D, Gonzalez-Ruiz V, Rudaz S
(2020) Implementation of liquid chromatography high resolution mass spectrometry methods
Analytical Approaches for the Determination and Identification of Drug. . .
519
an unregulated approach. Curr Opin Environ Sci Health 2:32–45
11. Deviller G, Lundy L, Fatta-Kassinos D (2020) Recommendations to derive quality standards for
chemical pollutants in reclaimed water intended for reuse in agricultural irrigation.
Chemosphere 240:124911
12. Wu X, Dodgen LK, Conkle JL, Gan J (2015) Plant uptake of pharmaceutical and personal care
products from recycled water and biosolids: a review. Sci Total Environ 536:655–666
13. Kaczala F, Blum SE (2016) The occurrence of veterinary pharmaceuticals in the environment: a
review. Curr Anal Chem 12:169–182
14. Bártíková H, Podlipná R, Skálová L (2016) Veterinary drugs in the environment and their
toxicity to plants. Chemosphere 144:2290–2301
15. Christou A, Papadavid G, Dalias P, Fotopoulos V, Michael C, Bayona JM, Piña B, Madikizela
LM, Ncube S, Chimuka L (2018) Uptake of pharmaceuticals by plants grown under hydroponic
conditions and natural occurring plant species: a review. Sci Total Environ 636:477–486
16. Bartrons M, Peñuelas J (2017) Pharmaceuticals and personal-care products in plants. Trends
Plant Sci 22:194–203
17. Madikizela LM, Ncube S, Chimuka L (2018) Uptake of pharmaceuticals by plants grown under
hydroponic conditions and natural occurring plant species: a review. Sci Total Environ
636:477–486
18. Reddy Pullagurala VL, Rawat S, Adisa IO, Hernandez-Viezcas JA, Peralta-Videa JR, GardeaTorresdey JL (2018) Plant uptake and translocation of contaminants of emerging concern in
soil. Sci Total Environ 636:1585–1596
19. Pico Y, Alfarham A, Barcelo D (2017) Analysis of emerging contaminants and nanomaterials in
plant materials following uptake from soils. Trends Anal Chem 94:173–189
20. Miller EL, Nason SL, Karthikeyan KG, Pedersen JA (2016) Root uptake of pharmaceuticals and
personal care product ingredients. Environ Sci Technol 50:525–541
21. Carvalho PN, Basto MCP, Almeida CMR, Brix H (2014) A review of plant–pharmaceutical
interactions: from uptake and effects in crop plants to phytoremediation in constructed wetlands. Environ Sci Pollut Res 21:11729–11763
22. Goldstein M, Shenker M, Chefetz B (2014) Insights into the uptake processes of wastewaterborne pharmaceuticals by vegetables. Environ Sci Technol 48:5593–5600
23. Kinney CA, Vanden Heuvel B (2020) Translocation of pharmaceuticals and personal care
products after land application of biosolids. Curr Opin Environ Sci Health 14:23–30
24. Fu Q, Malchi T, Carter LJ, Li H, Gan J, Chefetz B (2019) Pharmaceutical and personal care
products: from wastewater treatment into agro-food systems. Environ Sci Technol
53:14083–14090
25. Klampfl CW (2019) Metabolization of pharmaceuticals by plants after uptake from water and
soil: a review. Trends Anal Chem 111:13–26
26. Bártíková H, Skálová L, Stuchlíková L, Vokřál I, Vaněk T, Podlipná R (2015) Xenobioticmetabolizing enzymes in plants and their role in uptake and biotransformation of veterinary
drugs in the environment. Drug Metab Rev 47:374–387
27. Cummins I, Dixon DP, Freitag-Pohl S, Skipsey M, Edwards R (2011) Multiple roles for plant
glutathione transferases in xenobiotic detoxification. Drug Metab Rev 43:266–280
28. Fu Q, Zhang J, Borchardt D, Schlenk D, Gan J (2017) Direct conjugation of emerging
contaminants in arabidopsis: indication for an overlooked risk in plants? Environ Sci Technol
51:6071–6081
29. Kazmi SR, Jun R, Yu M-S, Jung C, Na D (2019) In silico approaches and tools for the
prediction of drug metabolism and fate: a review. Comput Biol Med 106:54–64
30. Nash WJ, Dunn WB (2019) From mass to metabolite in human untargeted metabolomics: recent
advances in annotation of metabolites applying liquid chromatography-mass spectrometry data.
Trends Anal Chem 120:115324
31. Pezzatti J, Boccard J, Codesido S, Gagnebin Y, Joshi A, Picard D, Gonzalez-Ruiz V, Rudaz S
(2020) Implementation of liquid chromatography high resolution mass spectrometry methods
Analytical Approaches for the Determination and Identification of Drug. . .
519