Table 1
(continued)
Parent drug(s)
Metabolites
Plant material
Growing conditions
Extraction/cleanup/
enrichment
Analysis of
extracts
Ref.
Phase
I
Phase
II
FBZ, FLU
x
x
Ribwort plantain
–
plant, cell suspension
Cultivated with Murashige and
Skoog medium (drug concentrations 1 mg L
À1
)
Liquid extraction of homogenized frozen samples
UPLCQqQ-MS
2
[87]
GEM
x
x
Arabidopsis thaliana
–
plant, cell suspension
Hydroponic in nutrient solution
(GEM 1 mg L
À1
) and cell culture (GEM 2.5 mg L
‑1
)
Liquid extraction of freezedried samples
SPE with Oasis HLB
LC-QqQMS
2
LC-TOFMS
[63]
IBU
x
x
Duckweed
– plant
Grown in Murashige and
Skoog medium (drug concentrations 1 mg L
À1
)
Liquid extraction of freezedried samples with sonication
SPE with Oasis HLB
OrbitrapMS
[77]
IBU
x
x
Phragmites australis
–
plant
Pots
filled with clean perlite
and culture medium (IBU
60
μg L
À1
)
Liquid extraction of frozen
samples
SPE with Oasis HLB
OrbitrapMS
[69]
IBU
x
x
Arabidopsis thaliana
–
cell suspension
Grown on medium (200
μM
IBU)
Liquid extraction of homogenized samples
SPE with Oasis HLB
LC-QTOFMS
2
OrbitrapMS
[79]
IBU
x
–
Typha angustifolia
–
plant
Horizontal subsurface
flow
constructed wetland system
(IBU 0.1 mg L
À1
)
Sea sand disruption method
LC-QqQMS
2
[70]
IBU
x
–
Duckweed
– plant
Grown in Murashige and
Skoog medium (IBU 0.02–
1 mg L
À1
)
Plant material ground in liquid nitrogen and extracted
with sonication
SPE with Oasis HLB
LC-FLD
[81]
508
F. Mlynek et al.