Table 6
(continued)
Matrix and target
molecules
Weight/
volume of
sample
Extraction solvent
Salts
Buffer
Clean-up
Analytical
method
Reference
25 mg PSA, 10 mg
GCB)
Lettuce, radish, and strawberry
–
74 microcontaminants
including pharmaceuticals,
metabolites, and pesticides
10 g wet
weight
10 mL of 1% acetic
acid in MeCN and
20
μL of the extraction quality control
solution, 10 mL of
MeCN
6 g of anhydrous MgSO
4
4 g of anhydrous MgSO
4 ,
1 g of NaCl
1.5 g of NaOAc
1 g trisodium citrate dehydrate
and 0.5 g
disodium
hydrogencitrate
sesquihydrate
d-SPE (750 mg of
anhydrous MgSO
4
and 125 mg of C18)
d-SPE (750 mg of
anhydrous MgSO
4 ,
125 mg of C18, and
125 mg of PSA)
HPLC-MS/
MS
[121]
Cabbage, cucumber, cauliflower, leek, and other
commonly consumed vegetables
– 49 antibiotics
(17 sulfonamides,
16 quinolones,
6 macrolides, 5
β-lactams,
5 tetracyclines)
10 g wet
weight
10 mL ACN
(0.248% H
3 PO
4 in
phosphate buffer
and 0.1% of formic
acid in formic acid
buffer)
4 g MgSO
4 , 1 g
NaCl
McIlvaine buffer
(0.049, or 0.19, or
0.46 g Na
2 HPO
4 ,
0.5 g citrate)
Phosphate buffer
(0.5 g KH
2 PO
4 )
Formic acid
buffer
d-SPE (10 mg PSA,
25 mg C18, 2.5 mg
GCB)
Other concentrations were tested
with less recovery
UHPLC-MS/
MS
[152]
14 different fruits and vegetables
– penicillins G and
V
1 g wet
weight
2 mL of ACN
0.5 g of NaCl
40 mg of EDTA
0.45
μm membrane
filter
HPLCQToF-MS/
MS
[123]
Lepidium sativum
–
diclofenac, ketoprofen,
naproxen, and mefenamic
acid
1 g wet
weight
3 mL ACN/0.1 M
HCl (2/1, v/v)
4 mL ACN/0.1 M
HCl (1/1, v/v)
0.8 g MgSO
4
and 0.2 g NaCl
1.2 g MgSO
4 ,
0.3 g NaCl
None
None
HPLC-MS/
MS
[153]
Leafy vegetables
–
20 antibiotics
10 g wet
weight
10 mL of
ACN/MeOH
(85:15, v/v)
4 g of anhydrous MgSO
4 ,
1 g of NaCl
1 g of citric acid
monohydrate,
0.5 g of trisodium
citrate dihydrate
C18 (30, 50, and
70 mg) and GCB
(10, 30, and 50 mg)
UHPLC-MS/
MS
[154]
454
R. Manasfi et al.
(continued)
Matrix and target
molecules
Weight/
volume of
sample
Extraction solvent
Salts
Buffer
Clean-up
Analytical
method
Reference
25 mg PSA, 10 mg
GCB)
Lettuce, radish, and strawberry
–
74 microcontaminants
including pharmaceuticals,
metabolites, and pesticides
10 g wet
weight
10 mL of 1% acetic
acid in MeCN and
20
μL of the extraction quality control
solution, 10 mL of
MeCN
6 g of anhydrous MgSO
4
4 g of anhydrous MgSO
4 ,
1 g of NaCl
1.5 g of NaOAc
1 g trisodium citrate dehydrate
and 0.5 g
disodium
hydrogencitrate
sesquihydrate
d-SPE (750 mg of
anhydrous MgSO
4
and 125 mg of C18)
d-SPE (750 mg of
anhydrous MgSO
4 ,
125 mg of C18, and
125 mg of PSA)
HPLC-MS/
MS
[121]
Cabbage, cucumber, cauliflower, leek, and other
commonly consumed vegetables
– 49 antibiotics
(17 sulfonamides,
16 quinolones,
6 macrolides, 5
β-lactams,
5 tetracyclines)
10 g wet
weight
10 mL ACN
(0.248% H
3 PO
4 in
phosphate buffer
and 0.1% of formic
acid in formic acid
buffer)
4 g MgSO
4 , 1 g
NaCl
McIlvaine buffer
(0.049, or 0.19, or
0.46 g Na
2 HPO
4 ,
0.5 g citrate)
Phosphate buffer
(0.5 g KH
2 PO
4 )
Formic acid
buffer
d-SPE (10 mg PSA,
25 mg C18, 2.5 mg
GCB)
Other concentrations were tested
with less recovery
UHPLC-MS/
MS
[152]
14 different fruits and vegetables
– penicillins G and
V
1 g wet
weight
2 mL of ACN
0.5 g of NaCl
40 mg of EDTA
0.45
μm membrane
filter
HPLCQToF-MS/
MS
[123]
Lepidium sativum
–
diclofenac, ketoprofen,
naproxen, and mefenamic
acid
1 g wet
weight
3 mL ACN/0.1 M
HCl (2/1, v/v)
4 mL ACN/0.1 M
HCl (1/1, v/v)
0.8 g MgSO
4
and 0.2 g NaCl
1.2 g MgSO
4 ,
0.3 g NaCl
None
None
HPLC-MS/
MS
[153]
Leafy vegetables
–
20 antibiotics
10 g wet
weight
10 mL of
ACN/MeOH
(85:15, v/v)
4 g of anhydrous MgSO
4 ,
1 g of NaCl
1 g of citric acid
monohydrate,
0.5 g of trisodium
citrate dihydrate
C18 (30, 50, and
70 mg) and GCB
(10, 30, and 50 mg)
UHPLC-MS/
MS
[154]
454
R. Manasfi et al.