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330. Wolters B, Fornefeld E, Jechalke S, Su J-Q, Zhu Y-G, Sørensen SJ, Smalla K, Jacquiod S
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331. Al-Ahmad A, Daschner FD, Kümmerer K (1999) Biodegradability of cefotiam, ciprofloxacin,
meropenem, penicillin G, and sulfamethoxazole and inhibition of waste water bacteria. Arch
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332. Kümmerer K, Al-Ahmad A, Mersch-Sundermann V (2000) Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test.
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333. Tomlinson TG, Boon AG, Trotman CNA (1966) Inhibition of nitrification in the activated
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334. Watkinson AJ, Murby EJ, Costanzo SD (2007) Removal of antibiotics in conventional and
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335. Rosendahl I, Siemens J, Kindler R, Groeneweg J, Zimmermann J, Czerwinski S, Lamshöft M,
Laabs V, Wilke B-M, Vereecken H, Amelung W (2012) Persistence of the fluoroquinolone
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336. Thiele-Bruhn S (2005) Microbial inhibition by pharmaceutical antibiotics in different soils-dose-response relations determined with the iron(III) reduction test. Environ Toxicol Chem
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337. Semedo M, Song B, Sparrer T, Phillips RL (2018) Antibiotic effects on microbial communities
responsible for denitrification and N2O production in grassland soils. Front Microbiol 9:2121.
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338. Boxall ABA, Fogg LA, Blackwell PA, Blackwell P, Kay P, Pemberton EJ, Croxford A (2004)
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toxicology. In: Reviews of environmental contamination and toxicology. Springer, New York,
pp 1–91. https://doi.org/10.1007/0-387-21729-0_1
339. Brandt KK, Sjøholm OR, Krogh KA, Halling-Sørensen B, Nybroe O (2009) Increased
pollution-induced bacterial community tolerance to sulfadiazine in soil hotspots amended
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es803546y
340. Cycoń M, Mrozik A, Piotrowska-Seget Z (2019) Antibiotics in the soil environment –
degradation and their impact on microbial activity and diversity. Front Microbiol 10:338.
https://doi.org/10.3389/fmicb.2019.00338
341. Grenni P, Ancona V, Barra Caracciolo A (2018) Ecological effects of antibiotics on natural
ecosystems: a review. Microchem J 136:25–39. https://doi.org/10.1016/j.microc.2017.02.006
342. Martinez JL (2009) Environmental pollution by antibiotics and by antibiotic resistance
determinants. Environ Pollut 157:2893–2902. https://doi.org/10.1016/j.envpol.2009.05.051
343. Piotrowska-Długosz A (2017) The effects of antibiotics on the structure, diversity, and
function of a soil microbial community. Springer, Cham, pp 283–312. https://doi.org/10.
1007/978-3-319-66260-2_15
344. Pan M, Chu LM (2016) Adsorption and degradation of five selected antibiotics in agricultural
soil. Sci Total Environ 545–546:48–56. https://doi.org/10.1016/j.scitotenv.2015.12.040
345. Braschi I, Blasioli S, Fellet C, Lorenzini R, Garelli A, Pori M, Giacomini D (2013) Persistence
and degradation of new β-lactam antibiotics in the soil and water environment. Chemosphere
93:152–159. https://doi.org/10.1016/j.chemosphere.2013.05.016
302
S. Gallego and F. Martin-Laurent
agricultural soil increases the abundance of antibiotic resistance genes without altering the
composition of prokaryotic communities. Sci Total Environ 647:1410–1420. https://doi.org/
10.1016/J.SCITOTENV.2018.08.092
330. Wolters B, Fornefeld E, Jechalke S, Su J-Q, Zhu Y-G, Sørensen SJ, Smalla K, Jacquiod S
(2018) Soil amendment with sewage sludge affects soil prokaryotic community composition,
mobilome and resistome. FEMS Microbiol Ecol. https://doi.org/10.1093/femsec/fiy193
331. Al-Ahmad A, Daschner FD, Kümmerer K (1999) Biodegradability of cefotiam, ciprofloxacin,
meropenem, penicillin G, and sulfamethoxazole and inhibition of waste water bacteria. Arch
Environ Contam Toxicol 37:158–163. https://doi.org/10.1007/s002449900501
332. Kümmerer K, Al-Ahmad A, Mersch-Sundermann V (2000) Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test.
Chemosphere 40:701–710. https://doi.org/10.1016/S0045-6535(99)00439-7
333. Tomlinson TG, Boon AG, Trotman CNA (1966) Inhibition of nitrification in the activated
sludge process of sewage disposal. J Appl Bacteriol 29:266–291. https://doi.org/10.1111/j.
1365-2672.1966.tb03477.x
334. Watkinson AJ, Murby EJ, Costanzo SD (2007) Removal of antibiotics in conventional and
advanced wastewater treatment: implications for environmental discharge and wastewater
recycling. Water Res 41:4164–4176. https://doi.org/10.1016/j.watres.2007.04.005
335. Rosendahl I, Siemens J, Kindler R, Groeneweg J, Zimmermann J, Czerwinski S, Lamshöft M,
Laabs V, Wilke B-M, Vereecken H, Amelung W (2012) Persistence of the fluoroquinolone
antibiotic difloxacin in soil and lacking effects on nitrogen turnover. J Environ Qual
41:1275–1283. https://doi.org/10.2134/jeq2011.0459
336. Thiele-Bruhn S (2005) Microbial inhibition by pharmaceutical antibiotics in different soils-dose-response relations determined with the iron(III) reduction test. Environ Toxicol Chem
24:869–876. https://doi.org/10.1897/04-166r.1
337. Semedo M, Song B, Sparrer T, Phillips RL (2018) Antibiotic effects on microbial communities
responsible for denitrification and N2O production in grassland soils. Front Microbiol 9:2121.
https://doi.org/10.3389/fmicb.2018.02121
338. Boxall ABA, Fogg LA, Blackwell PA, Blackwell P, Kay P, Pemberton EJ, Croxford A (2004)
Veterinary medicines in the environment BT – reviews of environmental contamination and
toxicology. In: Reviews of environmental contamination and toxicology. Springer, New York,
pp 1–91. https://doi.org/10.1007/0-387-21729-0_1
339. Brandt KK, Sjøholm OR, Krogh KA, Halling-Sørensen B, Nybroe O (2009) Increased
pollution-induced bacterial community tolerance to sulfadiazine in soil hotspots amended
with artificial root exudates. Environ Sci Technol 43:2963–2968. https://doi.org/10.1021/
es803546y
340. Cycoń M, Mrozik A, Piotrowska-Seget Z (2019) Antibiotics in the soil environment –
degradation and their impact on microbial activity and diversity. Front Microbiol 10:338.
https://doi.org/10.3389/fmicb.2019.00338
341. Grenni P, Ancona V, Barra Caracciolo A (2018) Ecological effects of antibiotics on natural
ecosystems: a review. Microchem J 136:25–39. https://doi.org/10.1016/j.microc.2017.02.006
342. Martinez JL (2009) Environmental pollution by antibiotics and by antibiotic resistance
determinants. Environ Pollut 157:2893–2902. https://doi.org/10.1016/j.envpol.2009.05.051
343. Piotrowska-Długosz A (2017) The effects of antibiotics on the structure, diversity, and
function of a soil microbial community. Springer, Cham, pp 283–312. https://doi.org/10.
1007/978-3-319-66260-2_15
344. Pan M, Chu LM (2016) Adsorption and degradation of five selected antibiotics in agricultural
soil. Sci Total Environ 545–546:48–56. https://doi.org/10.1016/j.scitotenv.2015.12.040
345. Braschi I, Blasioli S, Fellet C, Lorenzini R, Garelli A, Pori M, Giacomini D (2013) Persistence
and degradation of new β-lactam antibiotics in the soil and water environment. Chemosphere
93:152–159. https://doi.org/10.1016/j.chemosphere.2013.05.016
302
S. Gallego and F. Martin-Laurent