247. Benotti MJ, Brownawell BJ (2009) Microbial degradation of pharmaceuticals in estuarine and
coastal seawater. Environ Pollut 157:994–1002. https://doi.org/10.1016/j.envpol.2008.10.009
248. Suarez S, Lema JM, Omil F (2010) Removal of pharmaceutical and personal care products
(PPCPs) under nitrifying and denitrifying conditions. Water Res 44:3214–3224. https://doi.
org/10.1016/j.watres.2010.02.040
249. Suárez S, Reif R, Lema JM, Omil F (2012) Mass balance of pharmaceutical and personal care
products in a pilot-scale single-sludge system: influence of T, SRT and recirculation ratio.
Chemosphere 89:164–171. https://doi.org/10.1016/j.chemosphere.2012.05.094
250. Beretsou VG, Psoma AK, Gago-Ferrero P, Aalizadeh R, Fenner K, Thomaidis NS (2016)
Identification of biotransformation products of citalopram formed in activated sludge. Water
Res 103:205–214. https://doi.org/10.1016/j.watres.2016.07.029
251. Brooks BW, Foran CM, Richards SM, Weston J, Turner PK, Stanley JK, Solomon KR,
Slattery M, La Point TW (2003) Aquatic ecotoxicology of fluoxetine. Toxicol Lett
142:169–183. https://doi.org/10.1016/S0378-4274(03)00066-3
252. Sehonova P, Svobodova Z, Dolezelova P, Vosmerova P, Faggio C (2018) Effects of waterborne antidepressants on non-target animals living in the aquatic environment: a review. Sci
Total Environ 631–632:789–794. https://doi.org/10.1016/j.scitotenv.2018.03.076
253. Silva LJG, Pereira AMPT, Meisel LM, Lino CM, Pena A (2015) Reviewing the serotonin
reuptake inhibitors (SSRIs) footprint in the aquatic biota: uptake, bioaccumulation and ecotoxicology. Environ Pollut 197:127–143. https://doi.org/10.1016/j.envpol.2014.12.002
254. Fong PP, Ford AT (2014) The biological effects of antidepressants on the molluscs and
crustaceans: a review. Aquat Toxicol 151:4–13. https://doi.org/10.1016/j.aquatox.2013.12.
003
255. Schultz MM, Painter MM, Bartell SE, Logue A, Furlong ET, Werner SL, Schoenfuss HL
(2011) Selective uptake and biological consequences of environmentally relevant antidepressant pharmaceutical exposures on male fathead minnows. Aquat Toxicol 104:38–47. https://
doi.org/10.1016/j.aquatox.2011.03.011
256. Munoz-Bellido JL, Munoz-Criado S, Garcìa-Rodrìguez JA (2000) Antimicrobial activity of
psychotropic drugs. Selective serotonin reuptake inhibitors. Int J Antimicrob Agents
14:177–180. https://doi.org/10.1016/S0924-8579(99)00154-5
257. Karine de Sousa A, Rocha JE, Gonçalves de Souza T, Sampaio de Freitas T, Ribeiro-Filho J,
Melo Coutinho HD (2018) New roles of fluoxetine in pharmacology: antibacterial effect and
modulation of antibiotic activity. Microb Pathog 123:368–371. https://doi.org/10.1016/j.
micpath.2018.07.040
258. Lukić I, Getselter D, Ziv O, Oron O, Reuveni E, Koren O, Elliott E (2019) Antidepressants
affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on
depressive-like behavior. Transl Psychiatry 9:1–16. https://doi.org/10.1038/s41398-0190466-x
259. Macdonald RL, McLean MJ (1986) Anticonvulsant drugs: mechanisms of action. Adv Neurol
44:713–736
260. Scheytt T, Mersmann P, Lindstädt R, Heberer T (2005) 1-Octanol/water partition coefficients
of 5 pharmaceuticals from human medical care: carbamazepine, clofibric acid, diclofenac,
ibuprofen, and propyphenazone. Water Air Soil Pollut 165:3–11. https://doi.org/10.1007/
s11270-005-3539-9
261. Clara M, Strenn B, Gans O, Martinez E, Kreuzinger N, Kroiss H (2005) Removal of selected
pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor
and conventional wastewater treatment plants. Water Res 39:4797–4807. https://doi.org/10.
1016/j.watres.2005.09.015
262. Matsuo H, Sakamoto H, Arizono K, Shinohara R (2011) Behavior of pharmaceuticals in waste
water treatment plant in Japan. Bull Environ Contam Toxicol 87:31–35. https://doi.org/10.
1007/s00128-011-0299-7
Impact of PhACs on Soil Microorganisms
297
coastal seawater. Environ Pollut 157:994–1002. https://doi.org/10.1016/j.envpol.2008.10.009
248. Suarez S, Lema JM, Omil F (2010) Removal of pharmaceutical and personal care products
(PPCPs) under nitrifying and denitrifying conditions. Water Res 44:3214–3224. https://doi.
org/10.1016/j.watres.2010.02.040
249. Suárez S, Reif R, Lema JM, Omil F (2012) Mass balance of pharmaceutical and personal care
products in a pilot-scale single-sludge system: influence of T, SRT and recirculation ratio.
Chemosphere 89:164–171. https://doi.org/10.1016/j.chemosphere.2012.05.094
250. Beretsou VG, Psoma AK, Gago-Ferrero P, Aalizadeh R, Fenner K, Thomaidis NS (2016)
Identification of biotransformation products of citalopram formed in activated sludge. Water
Res 103:205–214. https://doi.org/10.1016/j.watres.2016.07.029
251. Brooks BW, Foran CM, Richards SM, Weston J, Turner PK, Stanley JK, Solomon KR,
Slattery M, La Point TW (2003) Aquatic ecotoxicology of fluoxetine. Toxicol Lett
142:169–183. https://doi.org/10.1016/S0378-4274(03)00066-3
252. Sehonova P, Svobodova Z, Dolezelova P, Vosmerova P, Faggio C (2018) Effects of waterborne antidepressants on non-target animals living in the aquatic environment: a review. Sci
Total Environ 631–632:789–794. https://doi.org/10.1016/j.scitotenv.2018.03.076
253. Silva LJG, Pereira AMPT, Meisel LM, Lino CM, Pena A (2015) Reviewing the serotonin
reuptake inhibitors (SSRIs) footprint in the aquatic biota: uptake, bioaccumulation and ecotoxicology. Environ Pollut 197:127–143. https://doi.org/10.1016/j.envpol.2014.12.002
254. Fong PP, Ford AT (2014) The biological effects of antidepressants on the molluscs and
crustaceans: a review. Aquat Toxicol 151:4–13. https://doi.org/10.1016/j.aquatox.2013.12.
003
255. Schultz MM, Painter MM, Bartell SE, Logue A, Furlong ET, Werner SL, Schoenfuss HL
(2011) Selective uptake and biological consequences of environmentally relevant antidepressant pharmaceutical exposures on male fathead minnows. Aquat Toxicol 104:38–47. https://
doi.org/10.1016/j.aquatox.2011.03.011
256. Munoz-Bellido JL, Munoz-Criado S, Garcìa-Rodrìguez JA (2000) Antimicrobial activity of
psychotropic drugs. Selective serotonin reuptake inhibitors. Int J Antimicrob Agents
14:177–180. https://doi.org/10.1016/S0924-8579(99)00154-5
257. Karine de Sousa A, Rocha JE, Gonçalves de Souza T, Sampaio de Freitas T, Ribeiro-Filho J,
Melo Coutinho HD (2018) New roles of fluoxetine in pharmacology: antibacterial effect and
modulation of antibiotic activity. Microb Pathog 123:368–371. https://doi.org/10.1016/j.
micpath.2018.07.040
258. Lukić I, Getselter D, Ziv O, Oron O, Reuveni E, Koren O, Elliott E (2019) Antidepressants
affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on
depressive-like behavior. Transl Psychiatry 9:1–16. https://doi.org/10.1038/s41398-0190466-x
259. Macdonald RL, McLean MJ (1986) Anticonvulsant drugs: mechanisms of action. Adv Neurol
44:713–736
260. Scheytt T, Mersmann P, Lindstädt R, Heberer T (2005) 1-Octanol/water partition coefficients
of 5 pharmaceuticals from human medical care: carbamazepine, clofibric acid, diclofenac,
ibuprofen, and propyphenazone. Water Air Soil Pollut 165:3–11. https://doi.org/10.1007/
s11270-005-3539-9
261. Clara M, Strenn B, Gans O, Martinez E, Kreuzinger N, Kroiss H (2005) Removal of selected
pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor
and conventional wastewater treatment plants. Water Res 39:4797–4807. https://doi.org/10.
1016/j.watres.2005.09.015
262. Matsuo H, Sakamoto H, Arizono K, Shinohara R (2011) Behavior of pharmaceuticals in waste
water treatment plant in Japan. Bull Environ Contam Toxicol 87:31–35. https://doi.org/10.
1007/s00128-011-0299-7
Impact of PhACs on Soil Microorganisms
297