enzymatic oxidative stress response. Fungal Biol 120:1249–1257. https://doi.org/10.1016/j.
funbio.2016.07.009
229. Hart A, Orr DL (1975) The degradation of paracetamol (4-hydroxyacetanilide) and other
substituted acetanilides by a Penicillium species. Antonie Van Leeuwenhoek 41:239–247.
https://doi.org/10.1007/bf02565059
230. Chopra S, Kumar D (2020) Characterization, optimization and kinetics study of acetaminophen degradation by Bacillus drentensis strain S1 and waste water degradation analysis.
Bioresour Bioprocess 7:9. https://doi.org/10.1186/s40643-020-0297-x
231. Hu J, Zhou L, Zhou Q, Wei F, Zhang L, Chen J (2012) Biodegradation of paracetamol by
aerobic granules in a sequencing batch reactor (SBR). Adv Mat Res 441:531–535
232. Wei F, Zhou Q, Leng S, Zhang L, Chen J (2011) Isolation, identification and biodegradation
characteristics of a new bacterial strain degrading paracetamol. Environ Sci 32:1813–1819
233. Wu S, Zhang L, Chen J (2012) Paracetamol in the environment and its degradation by
microorganisms. Appl Microbiol Biotechnol 96:875–884. https://doi.org/10.1007/s00253012-4414-4
234. De Oliveira LLD, Antunes SC, Gonçalves F, Rocha O, Nunes B (2016) Acute and chronic
ecotoxicological effects of four pharmaceuticals drugs on cladoceran Daphnia magna. Drug
Chem Toxicol 39:13–21. https://doi.org/10.3109/01480545.2015.1029048
235. Kim Y, Choi K, Jung J, Park S, Kim PG, Park J (2007) Aquatic toxicity of acetaminophen,
carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environ Int 33:370–375. https://doi.org/10.1016/j.envint.2006.11.017
236. Nunes B, Antunes SC, Santos J, Martins L, Castro BB (2014) Toxic potential of paracetamol
to freshwater organisms: a headache to environmental regulators? Ecotoxicol Environ Saf
107:178–185. https://doi.org/10.1016/j.ecoenv.2014.05.027
237. Alvarino T, Katsou E, Malamis S, Suarez S, Omil F, Fatone F (2014) Inhibition of biomass
activity in the via nitrite nitrogen removal processes by veterinary pharmaceuticals. Bioresour
Technol 152:477–483. https://doi.org/10.1016/j.biortech.2013.10.107
238. Calisto V, Esteves VI (2009) Psychiatric pharmaceuticals in the environment. Chemosphere
77:1257–1274. https://doi.org/10.1016/j.chemosphere.2009.09.021
239. Kinney CA, Furlong ET, Werner SL, Cahill JD (2006) Presence and distribution of
wastewater-derived pharmaceuticals in soil irrigated with reclaimed water. Environ Toxicol
Chem 25:317. https://doi.org/10.1897/05-187R.1
240. Kinney CA, Furlong ET, Zaugg SD, Burkhardt MR, Werner SL, Cahill JD, Jorgensen GR
(2006) Survey of organic wastewater contaminants in biosolids destined for land application.
Environ Sci Technol 40:7207–7215. https://doi.org/10.1021/es0603406
241. Schultz MM, Furlong ET (2008) Trace analysis of antidepressant pharmaceuticals and their
select degradates in aquatic matrixes by LC/ESI/MS/MS. Anal Chem 80:1756–1762. https://
doi.org/10.1021/ac702154e
242. Silva LJG, Lino CM, Meisel LM, Pena A (2012) Selective serotonin re-uptake inhibitors
(SSRIs) in the aquatic environment: an ecopharmacovigilance approach. Sci Total Environ
437:185–195. https://doi.org/10.1016/j.scitotenv.2012.08.021
243. Kwon J-W, Armbrust KL (2006) Laboratory persistence and fate of fluoxetine in aquatic
environments. Environ Toxicol Chem 25:2561. https://doi.org/10.1897/05-613R.1
244. Styrishave B, Halling-Sørensen B, Ingerslev F (2011) Environmental risk assessment of three
selective serotonin reuptake inhibitors in the aquatic environment: a case study including a
cocktail scenario. Environ Toxicol Chem 30:254–261. https://doi.org/10.1002/etc.372
245. Ribeiro AR, Afonso CM, Castro PML, Tiritan ME (2013) Enantioselective HPLC analysis and
biodegradation of atenolol, metoprolol and fluoxetine. Environ Chem Lett 11:83–90. https://
doi.org/10.1007/s10311-012-0383-1
246. Velázquez YF, Nacheva PM (2017) Biodegradability of fluoxetine, mefenamic acid, and
metoprolol using different microbial consortiums. Environ Sci Pollut Res 24:6779–6793.
https://doi.org/10.1007/s11356-017-8413-y
296
S. Gallego and F. Martin-Laurent
funbio.2016.07.009
229. Hart A, Orr DL (1975) The degradation of paracetamol (4-hydroxyacetanilide) and other
substituted acetanilides by a Penicillium species. Antonie Van Leeuwenhoek 41:239–247.
https://doi.org/10.1007/bf02565059
230. Chopra S, Kumar D (2020) Characterization, optimization and kinetics study of acetaminophen degradation by Bacillus drentensis strain S1 and waste water degradation analysis.
Bioresour Bioprocess 7:9. https://doi.org/10.1186/s40643-020-0297-x
231. Hu J, Zhou L, Zhou Q, Wei F, Zhang L, Chen J (2012) Biodegradation of paracetamol by
aerobic granules in a sequencing batch reactor (SBR). Adv Mat Res 441:531–535
232. Wei F, Zhou Q, Leng S, Zhang L, Chen J (2011) Isolation, identification and biodegradation
characteristics of a new bacterial strain degrading paracetamol. Environ Sci 32:1813–1819
233. Wu S, Zhang L, Chen J (2012) Paracetamol in the environment and its degradation by
microorganisms. Appl Microbiol Biotechnol 96:875–884. https://doi.org/10.1007/s00253012-4414-4
234. De Oliveira LLD, Antunes SC, Gonçalves F, Rocha O, Nunes B (2016) Acute and chronic
ecotoxicological effects of four pharmaceuticals drugs on cladoceran Daphnia magna. Drug
Chem Toxicol 39:13–21. https://doi.org/10.3109/01480545.2015.1029048
235. Kim Y, Choi K, Jung J, Park S, Kim PG, Park J (2007) Aquatic toxicity of acetaminophen,
carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environ Int 33:370–375. https://doi.org/10.1016/j.envint.2006.11.017
236. Nunes B, Antunes SC, Santos J, Martins L, Castro BB (2014) Toxic potential of paracetamol
to freshwater organisms: a headache to environmental regulators? Ecotoxicol Environ Saf
107:178–185. https://doi.org/10.1016/j.ecoenv.2014.05.027
237. Alvarino T, Katsou E, Malamis S, Suarez S, Omil F, Fatone F (2014) Inhibition of biomass
activity in the via nitrite nitrogen removal processes by veterinary pharmaceuticals. Bioresour
Technol 152:477–483. https://doi.org/10.1016/j.biortech.2013.10.107
238. Calisto V, Esteves VI (2009) Psychiatric pharmaceuticals in the environment. Chemosphere
77:1257–1274. https://doi.org/10.1016/j.chemosphere.2009.09.021
239. Kinney CA, Furlong ET, Werner SL, Cahill JD (2006) Presence and distribution of
wastewater-derived pharmaceuticals in soil irrigated with reclaimed water. Environ Toxicol
Chem 25:317. https://doi.org/10.1897/05-187R.1
240. Kinney CA, Furlong ET, Zaugg SD, Burkhardt MR, Werner SL, Cahill JD, Jorgensen GR
(2006) Survey of organic wastewater contaminants in biosolids destined for land application.
Environ Sci Technol 40:7207–7215. https://doi.org/10.1021/es0603406
241. Schultz MM, Furlong ET (2008) Trace analysis of antidepressant pharmaceuticals and their
select degradates in aquatic matrixes by LC/ESI/MS/MS. Anal Chem 80:1756–1762. https://
doi.org/10.1021/ac702154e
242. Silva LJG, Lino CM, Meisel LM, Pena A (2012) Selective serotonin re-uptake inhibitors
(SSRIs) in the aquatic environment: an ecopharmacovigilance approach. Sci Total Environ
437:185–195. https://doi.org/10.1016/j.scitotenv.2012.08.021
243. Kwon J-W, Armbrust KL (2006) Laboratory persistence and fate of fluoxetine in aquatic
environments. Environ Toxicol Chem 25:2561. https://doi.org/10.1897/05-613R.1
244. Styrishave B, Halling-Sørensen B, Ingerslev F (2011) Environmental risk assessment of three
selective serotonin reuptake inhibitors in the aquatic environment: a case study including a
cocktail scenario. Environ Toxicol Chem 30:254–261. https://doi.org/10.1002/etc.372
245. Ribeiro AR, Afonso CM, Castro PML, Tiritan ME (2013) Enantioselective HPLC analysis and
biodegradation of atenolol, metoprolol and fluoxetine. Environ Chem Lett 11:83–90. https://
doi.org/10.1007/s10311-012-0383-1
246. Velázquez YF, Nacheva PM (2017) Biodegradability of fluoxetine, mefenamic acid, and
metoprolol using different microbial consortiums. Environ Sci Pollut Res 24:6779–6793.
https://doi.org/10.1007/s11356-017-8413-y
296
S. Gallego and F. Martin-Laurent