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org/10.1016/j.watres.2006.05.036
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to green chemistry. Chem Rev 107:2319–2364. https://doi.org/10.1021/cr020441w
222. Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT (2002)
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10.1021/es011055j
223. Kosma CI, Lambropoulou DA, Albanis TA (2010) Occurrence and removal of PPCPs in
municipal and hospital wastewaters in Greece. J Hazard Mater 179:804–817. https://doi.org/
10.1016/j.jhazmat.2010.03.075
224. Luo Y, Guo W, Ngo HH, Nghiem LD, Hai FI, Zhang J, Liang S, Wang XC (2014) A review on
the occurrence of micropollutants in the aquatic environment and their fate and removal during
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scitotenv.2013.12.065
225. Mutiyar PK, Gupta SK, Mittal AK (2018) Fate of pharmaceutical active compounds (PhACs)
from River Yamuna, India: an ecotoxicological risk assessment approach. Ecotoxicol Environ
Saf 150:297–304. https://doi.org/10.1016/j.ecoenv.2017.12.041
226. Roberts PH, Thomas KV (2006) The occurrence of selected pharmaceuticals in wastewater
effluent and surface waters of the lower Tyne catchment. Sci Total Environ 356:143–153.
https://doi.org/10.1016/j.scitotenv.2005.04.031
227. Wiegel S, Aulinger A, Brockmeyer R, Harms H, Löffler J, Reincke H, Schmidt R, Stachel B,
Von Tümpling W, Wanke A (2004) Pharmaceuticals in the river Elbe and its tributaries.
Chemosphere 57:107–126. https://doi.org/10.1016/j.chemosphere.2004.05.017
228. Esterhuizen-Londt M, Schwartz K, Pflugmacher S (2016) Using aquatic fungi for pharmaceutical bioremediation: uptake of acetaminophen by Mucor hiemalis does not result in an
Impact of PhACs on Soil Microorganisms
295
combination with streptomycin against Mycobacterium tuberculosis in mice. Int J Antimicrob
Agents 30:336–340. https://doi.org/10.1016/j.ijantimicag.2007.04.016
213. Thelusmond JR, Strathmann TJ, Cupples AM (2016) The identification of carbamazepine
biodegrading phylotypes and phylotypes sensitive to carbamazepine exposure in two soil
microbial communities. Sci Total Environ 571:1241–1252. https://doi.org/10.1016/j.scitotenv.
2016.07.154
214. Anderson BJ (2008) Paracetamol (Acetaminophen): mechanisms of action. Pediatr Anesth
18:915–921. https://doi.org/10.1111/j.1460-9592.2008.02764.x
215. Jozwiak-Bebenista M, Nowak JZ (2014) Paracetamol: mechanism of action, applications and
safety concern. Acta Pol Pharm Drug Res 71:11–23
216. Bound JP, Voulvoulis N (2006) Predicted and measured concentrations for selected pharmaceuticals in UK rivers: implications for risk assessment. Water Res 40:2885–2892. https://doi.
org/10.1016/j.watres.2006.05.036
217. Chinnaiyan P, Thampi SG, Kumar M, Mini KM (2018) Pharmaceutical products as emerging
contaminant in water: relevance for developing nations and identification of critical compounds for Indian environment. Environ Monit Assess 190:1–13. https://doi.org/10.1007/
s10661-018-6672-9
218. Gómez MJ, Martínez Bueno MJ, Lacorte S, Fernández-Alba AR, Agüera A (2007) Pilot
survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located
on the Mediterranean coast. Chemosphere 66:993–1002. https://doi.org/10.1016/j.
chemosphere.2006.07.051
219. Gros M, Petrović M, Barceló D (2006) Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening
and trace level determination of pharmaceuticals in surface and wastewaters. Talanta
70:678–690. https://doi.org/10.1016/j.talanta.2006.05.024
220. Grujić S, Vasiljević T, Laušević M (2009) Determination of multiple pharmaceutical classes in
surface and ground waters by liquid chromatography-ion trap-tandem mass spectrometry. J
Chromatogr A 1216:4989–5000. https://doi.org/10.1016/j.chroma.2009.04.059
221. Khetan SK, Collins TJ (2007) Human pharmaceuticals in the aquatic environment: a challenge
to green chemistry. Chem Rev 107:2319–2364. https://doi.org/10.1021/cr020441w
222. Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT (2002)
Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams,
1999-2000: a national reconnaissance. Environ Sci Technol 36:1202–1211. https://doi.org/
10.1021/es011055j
223. Kosma CI, Lambropoulou DA, Albanis TA (2010) Occurrence and removal of PPCPs in
municipal and hospital wastewaters in Greece. J Hazard Mater 179:804–817. https://doi.org/
10.1016/j.jhazmat.2010.03.075
224. Luo Y, Guo W, Ngo HH, Nghiem LD, Hai FI, Zhang J, Liang S, Wang XC (2014) A review on
the occurrence of micropollutants in the aquatic environment and their fate and removal during
wastewater treatment. Sci Total Environ 473–474:619–641. https://doi.org/10.1016/j.
scitotenv.2013.12.065
225. Mutiyar PK, Gupta SK, Mittal AK (2018) Fate of pharmaceutical active compounds (PhACs)
from River Yamuna, India: an ecotoxicological risk assessment approach. Ecotoxicol Environ
Saf 150:297–304. https://doi.org/10.1016/j.ecoenv.2017.12.041
226. Roberts PH, Thomas KV (2006) The occurrence of selected pharmaceuticals in wastewater
effluent and surface waters of the lower Tyne catchment. Sci Total Environ 356:143–153.
https://doi.org/10.1016/j.scitotenv.2005.04.031
227. Wiegel S, Aulinger A, Brockmeyer R, Harms H, Löffler J, Reincke H, Schmidt R, Stachel B,
Von Tümpling W, Wanke A (2004) Pharmaceuticals in the river Elbe and its tributaries.
Chemosphere 57:107–126. https://doi.org/10.1016/j.chemosphere.2004.05.017
228. Esterhuizen-Londt M, Schwartz K, Pflugmacher S (2016) Using aquatic fungi for pharmaceutical bioremediation: uptake of acetaminophen by Mucor hiemalis does not result in an
Impact of PhACs on Soil Microorganisms
295