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147. Ternes TA (1998) Occurrence of drugs in German sewage treatment plants and rivers. Water
Res 32:3245–3260. https://doi.org/10.1016/S0043-1354(98)00099-2
148. Tewari S, Jindal R, Kho YL, Eo S, Choi K (2013) Major pharmaceutical residues in
wastewater treatment plants and receiving waters in Bangkok, Thailand, and associated
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S. Gallego and F. Martin-Laurent
Water Res 44:6011–6020. https://doi.org/10.1016/j.watres.2010.07.051
132. Waria M, O’Connor GA, Toor GS (2011) Biodegradation of triclosan in biosolids-amended
soils. Environ Toxicol Chem 30:2488–2496. https://doi.org/10.1002/etc.666
133. Ying GG, Yu XY, Kookana RS (2007) Biological degradation of triclocarban and triclosan in
a soil under aerobic and anaerobic conditions and comparison with environmental fate
modelling. Environ Pollut 150:300–305. https://doi.org/10.1016/j.envpol.2007.02.013
134. Chen ZF, Ying GG, Ma YB, Lai HJ, Chen F, Pan CG (2013) Occurrence and dissipation of
three azole biocides climbazole, clotrimazole and miconazole in biosolid-amended soils. Sci
Total Environ 452–453:377–383. https://doi.org/10.1016/j.scitotenv.2013.03.004
135. García-Valcárcel AI, Tadeo JL (2012) Influence of moisture on the availability and persistence
of clotrimazole and fluconazole in sludge-amended soil. Environ Toxicol Chem 31:501–507.
https://doi.org/10.1002/etc.1711
136. Sabourin L, Al-Rajab AJ, Chapman R, Lapen DR, Topp E (2011) Fate of the antifungal drug
clotrimazole in agricultural soil. Environ Toxicol Chem 30:582–587. https://doi.org/10.1002/
etc.432
137. Brodin T, Piovano S, Fick J, Klaminder J, Heynen M, Jonsson M (2014) Ecological effects of
pharmaceuticals in aquatic systems – impacts through behavioural alterations. Philos Trans R
Soc B Biol Sci 369. https://doi.org/10.1098/rstb.2013.0580
138. Fent K (2008) Effects of pharmaceuticals on aquatic organisms. In: Pharmaceuticals in the
environment. Springer, Berlin, pp 175–203. https://doi.org/10.1007/978-3-540-74664-5_12
139. Gaw S, Thomas KV, Hutchinson TH (2014) Sources, impacts and trends of pharmaceuticals in
the marine and coastal environment. Philos Trans R Soc B Biol Sci 369. https://doi.org/10.
1098/rstb.2013.0572
140. Patel M, Kumar R, Kishor K, Mlsna T, Pittman CU, Mohan D (2019) Pharmaceuticals of
emerging concern in aquatic systems: chemistry, occurrence, effects, and removal methods.
Chem Rev 119:3510–3673. https://doi.org/10.1021/acs.chemrev.8b00299
141. Heuer H, Schmitt H, Smalla K (2011) Antibiotic resistance gene spread due to manure
application on agricultural fields. Curr Opin Microbiol 14:236–243. https://doi.org/10.1016/
j.mib.2011.04.009
142. Ghlichloo I, Gerriets V (2020) Nonsteroidal anti-inflammatory drugs (NSAIDs). In: Treatment
of chronic pain conditions: a comprehensive handbook. Springer, New York, pp 77–79.
https://doi.org/10.1007/978-1-4939-6976-0_21
143. Farré M, Ferrer I, Ginebreda A, Figueras M, Olivella L, Tirapu L, Vilanova M, Barceló D
(2001) Determination of drugs in surface water and wastewater samples by liquid
chromatography-mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri. J Chromatogr A:187–197. https://doi.org/10.1016/S0021-9673(01)
01154-2
144. Kermia AEB, Fouial-Djebbar D, Trari M (2016) Occurrence, fate and removal efficiencies of
pharmaceuticals in wastewater treatment plants (WWTPs) discharging in the coastal environment of Algiers. C R Chim 19:963–970. https://doi.org/10.1016/j.crci.2016.05.005
145. Madikizela LM, Chimuka L (2017) Occurrence of naproxen, ibuprofen, and diclofenac
residues in wastewater and river water of KwaZulu-Natal Province in South Africa. Environ
Monit Assess 189:348. https://doi.org/10.1007/s10661-017-6069-1
146. Santos JL, Aparicio I, Alonso E (2007) Occurrence and risk assessment of pharmaceutically
active compounds in wastewater treatment plants. A case study: Seville city (Spain). Environ
Int 33:596–601. https://doi.org/10.1016/j.envint.2006.09.014
147. Ternes TA (1998) Occurrence of drugs in German sewage treatment plants and rivers. Water
Res 32:3245–3260. https://doi.org/10.1016/S0043-1354(98)00099-2
148. Tewari S, Jindal R, Kho YL, Eo S, Choi K (2013) Major pharmaceutical residues in
wastewater treatment plants and receiving waters in Bangkok, Thailand, and associated
290
S. Gallego and F. Martin-Laurent