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importance in metabolism, the role of glycine N-acyltransferase, and factors that influence
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20. Hayes JD, Flanagan JU, Jowsey IR (2005) Glutathione transferases. Annu Rev Pharmacol
Toxicol 45:51–88
21. Edwards R, Dixon DP, Cummins I et al (2011) New perspectives on the metabolism and
detoxification of synthetic compounds in plants. In: Schröder P, Collins C (eds) Organic
xenobiotics and plants. Plant ecophysiology, vol 8. Springer, Dordrecht, pp 125–148
22. Shimabukuro RH, Walsh WC, Hoerauf RA (1979) Metabolism and selectivity of diclofopmethyl in wild oat and wheat. J Agric Food Chem 27:615–623. https://doi.org/10.1021/
jf60223a008
23. Sandermann Jr H (1994) Higher plant metabolism of xenobiotics: the “green liver” concept.
Pharmacogenetics 4:225–241. https://doi.org/10.1097/00008571-199410000-00001
24. Cole DJ (1994) Detoxification and activation of agrochemicals in plants. Pestic Sci 42:209–
222
25. Menn JJ (1978) Comparative aspects of pesticide metabolism in plants and animals. Environ
Health Perspect 27:113–124. https://doi.org/10.2307/3428870
26. Huber C, Bartha B, Harpaintner R, Schröder P (2009) Metabolism of acetaminophen (paracetamol) in plants–two independent pathways result in the formation of a glutathione and a
glucose conjugate. Environ Sci Pollut Res Int 16:206. https://doi.org/10.1007/s11356-0080095-z
27. Li Y, Chuang YH, Sallach JB et al (2018) Potential metabolism of pharmaceuticals in radish:
comparison of in vivo and in vitro exposure. Environ Pollut 242:962–969. https://doi.org/10.
1016/j.envpol.2018.07.060
28. Riemenschneider C, Seiwert B, Moeder M et al (2017) Extensive transformation of the
pharmaceutical carbamazepine following uptake into intact tomato plants. Environ Sci
Technol 51:6100–6109. https://doi.org/10.1021/acs.est.6b06485
29. Sauvêtre A, May R, Harpaintner R et al (2018) Metabolism of carbamazepine in plant roots
and endophytic rhizobacteria isolated from Phragmites australis. J Hazard Mater 342:85–95.
https://doi.org/10.1016/j.jhazmat.2017.08.006
30. Dordio AV, Belo M, Martins Teixeira D et al (2011) Evaluation of carbamazepine uptake and
metabolization by Typha spp., a plant with potential use in phytotreatment. Bioresour Technol
102:7827–7834. https://doi.org/10.1016/j.biortech.2011.06.050
31. Goldstein M, Malchi T, Shenker M, Chefetz B (2018) Pharmacokinetics in plants : carbamazepine and its interactions with lamotrigine. Environ Sci Technol 52:6957–6964. https://doi.
org/10.1021/acs.est.8b01682
32. Wu C, Spongberg AL, Witter JD et al (2010) Uptake of pharmaceutical and personal care
products by soybean plants from soils applied with biosolids and irrigated with contaminated
water. Environ Sci Technol 44:6157–6161. https://doi.org/10.1021/es1011115
33. Zhao HM, Huang HB, Du H, Lin J, Xiang L, Li YW, Cai QY, Li H, Mo CH, Liu JS, Wong
MH (2018) Intraspecific variability of ciprofloxacin accumulation, tolerance, and metabolism
in Chinese flowering cabbage (Brassica parachinensis). J Hazard Mater 349:252–261. https://
doi.org/10.1016/j.jhazmat.2018.01.015
34. Reichl B, Himmelsbach M, Emhofer L et al (2018) Uptake and metabolism of the antidepressants sertraline, clomipramine and trazodone in a garden cress (Lepidium sativum) model.
Electrophoresis 39:1301–1308. https://doi.org/10.1002/elps.201700482
35. Carter LJ, Williams M, Martin S, Kamaludeen SPB, Kookana RS (2018) Sorption, plant
uptake and metabolism of benzodiazepines. Sci Total Env 628–629:18–25. https://doi.org/10.
1016/j.scitotenv.2018.01.337
36. Dudley S, Sun C, McGinnis M, Trumble J, Gan J (2019) Formation of biologically active
benzodiazepine metabolites in Arabidopsis thaliana cell cultures and vegetable plants under
hydroponic conditions. Sci Total Environ 662:622–630. https://doi.org/10.1016/j.scitotenv.
2019.01.259
258
A. Sauvêtre et al.
importance in metabolism, the role of glycine N-acyltransferase, and factors that influence
interindividual variation. Expert Opin Drug Metab Toxicol 9:1139–1153. https://doi.org/10.
1517/17425255.2013.796929
20. Hayes JD, Flanagan JU, Jowsey IR (2005) Glutathione transferases. Annu Rev Pharmacol
Toxicol 45:51–88
21. Edwards R, Dixon DP, Cummins I et al (2011) New perspectives on the metabolism and
detoxification of synthetic compounds in plants. In: Schröder P, Collins C (eds) Organic
xenobiotics and plants. Plant ecophysiology, vol 8. Springer, Dordrecht, pp 125–148
22. Shimabukuro RH, Walsh WC, Hoerauf RA (1979) Metabolism and selectivity of diclofopmethyl in wild oat and wheat. J Agric Food Chem 27:615–623. https://doi.org/10.1021/
jf60223a008
23. Sandermann Jr H (1994) Higher plant metabolism of xenobiotics: the “green liver” concept.
Pharmacogenetics 4:225–241. https://doi.org/10.1097/00008571-199410000-00001
24. Cole DJ (1994) Detoxification and activation of agrochemicals in plants. Pestic Sci 42:209–
222
25. Menn JJ (1978) Comparative aspects of pesticide metabolism in plants and animals. Environ
Health Perspect 27:113–124. https://doi.org/10.2307/3428870
26. Huber C, Bartha B, Harpaintner R, Schröder P (2009) Metabolism of acetaminophen (paracetamol) in plants–two independent pathways result in the formation of a glutathione and a
glucose conjugate. Environ Sci Pollut Res Int 16:206. https://doi.org/10.1007/s11356-0080095-z
27. Li Y, Chuang YH, Sallach JB et al (2018) Potential metabolism of pharmaceuticals in radish:
comparison of in vivo and in vitro exposure. Environ Pollut 242:962–969. https://doi.org/10.
1016/j.envpol.2018.07.060
28. Riemenschneider C, Seiwert B, Moeder M et al (2017) Extensive transformation of the
pharmaceutical carbamazepine following uptake into intact tomato plants. Environ Sci
Technol 51:6100–6109. https://doi.org/10.1021/acs.est.6b06485
29. Sauvêtre A, May R, Harpaintner R et al (2018) Metabolism of carbamazepine in plant roots
and endophytic rhizobacteria isolated from Phragmites australis. J Hazard Mater 342:85–95.
https://doi.org/10.1016/j.jhazmat.2017.08.006
30. Dordio AV, Belo M, Martins Teixeira D et al (2011) Evaluation of carbamazepine uptake and
metabolization by Typha spp., a plant with potential use in phytotreatment. Bioresour Technol
102:7827–7834. https://doi.org/10.1016/j.biortech.2011.06.050
31. Goldstein M, Malchi T, Shenker M, Chefetz B (2018) Pharmacokinetics in plants : carbamazepine and its interactions with lamotrigine. Environ Sci Technol 52:6957–6964. https://doi.
org/10.1021/acs.est.8b01682
32. Wu C, Spongberg AL, Witter JD et al (2010) Uptake of pharmaceutical and personal care
products by soybean plants from soils applied with biosolids and irrigated with contaminated
water. Environ Sci Technol 44:6157–6161. https://doi.org/10.1021/es1011115
33. Zhao HM, Huang HB, Du H, Lin J, Xiang L, Li YW, Cai QY, Li H, Mo CH, Liu JS, Wong
MH (2018) Intraspecific variability of ciprofloxacin accumulation, tolerance, and metabolism
in Chinese flowering cabbage (Brassica parachinensis). J Hazard Mater 349:252–261. https://
doi.org/10.1016/j.jhazmat.2018.01.015
34. Reichl B, Himmelsbach M, Emhofer L et al (2018) Uptake and metabolism of the antidepressants sertraline, clomipramine and trazodone in a garden cress (Lepidium sativum) model.
Electrophoresis 39:1301–1308. https://doi.org/10.1002/elps.201700482
35. Carter LJ, Williams M, Martin S, Kamaludeen SPB, Kookana RS (2018) Sorption, plant
uptake and metabolism of benzodiazepines. Sci Total Env 628–629:18–25. https://doi.org/10.
1016/j.scitotenv.2018.01.337
36. Dudley S, Sun C, McGinnis M, Trumble J, Gan J (2019) Formation of biologically active
benzodiazepine metabolites in Arabidopsis thaliana cell cultures and vegetable plants under
hydroponic conditions. Sci Total Environ 662:622–630. https://doi.org/10.1016/j.scitotenv.
2019.01.259
258
A. Sauvêtre et al.