Table 1
(continued)
Compound
Human metabolites
Plant metabolites
Plant species
Ref.
Ketoprofen
(KPF)
Phase II: KPF-AGluc
Phase II: KPF-Hex, KPF-Hex-Mal,
KPF-Gln, KPF-Glu
Lepidium sativum
[39, 40]
Mefenamic acid
(MFA)
Phase I: 3-methylhydroxy MFA,
3-carboxy-MFA
Phase II: FA-AGluc, MFA-Gly
Phase II: MFA-Hex-Mal,
OH-MFA-Hex, OH-MFA-Hex-Mal
Lepidium sativum
[39, 40]
Metformin
(MFM)
Not metabolized
Phase I: N-desmethyl-MFM
Typha latifolia
[49]
Naproxen
(NPX)
Phase I: O-desmethyl-NPX
Phase II: NPX-O-Gluc, O-desmethylNPX-Sulf, O-desmethyl-NPX-AGluc,
O-desmethyl-NPX-O-Gluc
Phase I: O-desmethyl-NPX
Phase II: NPX-Hex, NPX-Hex-Mal,
NPX-Ala-Glu, NPX-Gln, NPX-Glu,
NPX-Gln-Glu, NPX-Ile-Glu, NPX-LeuGlu, NPX-Phe-Glu, , NPX-Thr-Ala,
NPX-Tyr-Gly-Gln, NPX-Val-Glu,
OH-NPX-Tyr-Gly-Gln
Lepidium sativum, Arabidopsis
thaliana
(cells)
[39–41]
Ofloxacin
(OFL)
Desmethyl-OFL, OFL-N-oxide
Phase I: OH-OFL, O-ethyl-OFL,
O-methyl-OFL, decarboxy-OFL,
N-desmethyl-OFL, OH-N-desmethylOFL
Phase II: OFL-Hex, OFL-Hex-Mal
Tomato and lettuce
[50, 51]
Sertraline (SRT) Phase I: N-desmethyl-SRT, SRT ketone
Phase II: SER N-carbamoyl-Gluc,
α-OH-SER ketone-Gluc
Phase I: two OH-SRT (unidentified
position of OH)
Phase II: N-desmethyl-SRT-Phe,
N-desmethyl-SRT-Tyr, OH-Ndesmethyl-SRT-Phe (unidentified position of OH)
Lepidium sativum
[34]
Trazodone
(TZD)
Phase I: 4-OH-TZD,
m-chlorophenylpiperazine,
triazolopyridinone dihydrodiol,
triazolopyridinone epoxide
Phase I: OH-TZD (unidentified position
of OH), m-chlorophenylpiperazine
Lepidium sativum
[34]
236
A. Sauvêtre et al.